Patents by Inventor Daniel Pipeleers

Daniel Pipeleers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SCREENING ASSAY FOR AGENTS THAT INFLUENCE BETA CELL NUMBER AND/OR PHENOTYPE
    Publication number: 20160274087
    Abstract: The present invention in general relates to a method for identifying compounds that influence beta cell number and/or phenotype, more in particular beta cell differentiation, proliferation and/or expansion. Said method comprising culturing beta cells or precursors thereof in 5 medium comprising glucose, and determining the ability of said compound to induce the glucocorticoid receptor dependent-transactivation pathway in said beta cells. It further relates to compounds identified in such methods, and uses of said compounds as positive controls in methods for identifying compounds that influence beta cell number and/or phenotype; or uses thereof in the treatment of pathologies characterized by changes in beta-cell number and/or 10 phenotype such as for example diabetes mellitus.
    Type: Application
    Filed: November 7, 2014
    Publication date: September 22, 2016
    Applicants: Vrije Universiteit Brussel, Opus NV
    Inventors: Zerihun Assefa, Geert Stange, Daniel Pipeleers, Karine Hellemans
  • Method for producing preparations of mature and immature pancreatic endocrine cells, the cell preparation and its use for treatment of diabetes mellitus
    Patent number: 6686197
    Abstract: A method for preparing a preparation of mammalian pancreatic endocrine cells comprising the steps: dissociating intact pancreatic tissue into a cell suspension comprising single cells and cell aggregates; enriching said cell suspension with regard to the content in endocrine cells by separating single cells and cellular aggregates with size <100 &mgr;m; and removing contaminating non-endocrine cells by density centrifugation.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: February 3, 2004
    Assignee: Beta-Cell, N.V.
    Inventor: Daniel Pipeleers
  • Method for producing preparations of mature and immature pancreatic endocrine cells, the cell preparation and its use for treatment of diabetes mellitus
    Publication number: 20020177228
    Abstract: A method for preparing a preparation of mammalian pancreatic endocrine cells comprising the steps: dissociating intact pancreatic tissue into a cell suspension comprising single cells and cell aggregates; enriching said cell suspension with regard to the content in endocrine cells by separating single cells and cellular aggregates with size <100 &mgr;m; and removing contaminating non-endocrine cells by density centrifugation.
    Type: Application
    Filed: April 12, 2001
    Publication date: November 28, 2002
    Applicant: Beta-Cell N.V.
    Inventor: Daniel Pipeleers