Abstract: The present invention is directed to N-linked lactam compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

Abstract: The present invention is directed to N-linked lactam compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

Abstract: Systems and methods for generating pages of content using API requests are described. Users can create web pages that are a collection of references to API queries. An example includes doors which are web pages that are portals to realms of content. Users can create doors by associating API references to a variety of previously created content assets which are called by the front-end to render the door when web users visit the door. The tool includes user interface elements that make creating and saving the API references easy. For example, pickers are provided for selecting API references to individual assets, query makers are provided for formulating previewing, merging and normalizing references to dynamic API searches, overriding functionality is provided for manually grooming the asset references returned by dynamic API searches or individual asset references, and the like.