Abstract: Described herein are screening methods to identify therapeutic compositions for the treatment of an intestinal inflammation, inflammatory bowel disease or pathogen infection, as well as therapeutic methods and compositions useful for ameliorating an intestinal inflammation, inflammatory bowel disease or pathogen infection.

Abstract: The invention features methods of preventing or treating epithelial cell lesions in a mammal by administering a composition containing a therapeutically effective amount of a trefoil domain-containing polypeptide, or a trefoil peptide fragment, and a mucoadhesive excipient. The invention further features methods of preventing or treating an eye disorder, e.g., dry eye, by topically administering to the eye a composition containing a therapeutically effective amount of a trefoil domain-containing polypeptide, or a trefoil peptide fragment, and a mucoadhesive excipient. Compositions containing a trefoil domain-containing polypeptide, or a trefoil peptide fragment, and a mucoadhesive excipient may be formulated in combination with one or more additional therapeutic agents and used in the methods of the invention.

Abstract: The invention features compositions containing an intestinal trefoil peptide and a mucoadhesive excipient. Such compounds are useful, e.g., for the treatment or prevention of lesions. Compositions containing an intestinal trefoil peptide and a mucoadhesive excipient may be formulated in combination with one or more additional therapeutic agents.