Abstract: Aspects of the subject disclosure may include, for example: determining whether a Subscriber Identify Module (SIM) profile that supports communication via Citizen Band Radio Spectrum (CBRS) is present on a device, resulting in a determination; responsive to the determination being that the SIM profile that supports the communication via the CBRS is present on the device, providing to a user via an interface an element that permits the user to select enabling of communication via the CBRS, disabling of communication via the CBRS, or any combination thereof; receiving from the interface a selection by the user, wherein the selection indicates either an instruction by the user to enable the communication via the CBRS, or an instruction by the user to disable the communication via the CBRS; and responsive to the selection: enabling the communication via the CBRS in a first case that the selection indicates the instruction by the user to enable the communication via the CBRS; or disabling the communication via the

Abstract: The invention includes a chimeric antigen receptor (CAR) specific for a natural-killer group 2, member D ligand (NKG2DL), compositions comprising the CAR, polynucleotides encoding the CAR, vectors comprising a polynucleotide encoding the CAR, and recombinant T cells comprising the CAR. The invention also includes methods of making a genetically modified T cell expressing a NKG2D-CAR wherein the expressed CAR comprises a NKG2D extracellular domain. The present invention also relates generally to the use of T cells engineered to express a CAR to treat cancer associated with NKG2D.

Abstract: A system enables a home operator to establish an automated monitoring process which identifies outage events on competitor wireless networks (e.g., peer operators) operating in the same geographies as home operator. The home operator then is able to selectively offer, in near real-time, to open roaming to the peer operator, or implement roaming automatically based on predefined and mutually agreed upon rule sets. The monitoring process may observe non-customer attach request volumes in order to identify outage events on competitor wireless networks.

Abstract: Aspects of the subject disclosure may include, for example: determining whether a Subscriber Identify Module (SIM) profile that supports communication via Citizen Band Radio Spectrum (CBRS) is present on a device, resulting in a determination; responsive to the determination being that the SIM profile that supports the communication via the CBRS is present on the device, providing to a user via an interface an element that permits the user to select enabling of communication via the CBRS, disabling of communication via the CBRS, or any combination thereof; receiving from the interface a selection by the user, wherein the selection indicates either an instruction by the user to enable the communication via the CBRS, or an instruction by the user to disable the communication via the CBRS; and responsive to the selection: enabling the communication via the CBRS in a first case that the selection indicates the instruction by the user to enable the communication via the CBRS; or disabling the communication via the

Abstract: A system enables a home operator to establish an automated monitoring process which identifies outage events on competitor wireless networks (e.g., peer operators) operating in the same geographies as home operator. The home operator then is able to selectively offer, in near real-time, to open roaming to the peer operator, or implement roaming automatically based on predefined and mutually agreed upon rule sets. The monitoring process may observe non-customer attach request volumes in order to identify outage events on competitor wireless networks.

Abstract: In an illustrative embodiment, methods and systems for attenuating effect(s) associated with reduction or cessation of substance use by an individual include providing a neurostimulation delivery system including a neurostimulation device having a first portion including a first electrode configured to electrically stimulate auricular branch(es) of the vagus nerve, and a second portion including a second electrode configured to electrically stimulate branch(es) of the auriculotemporal nerve, and a pulse generator including circuitry configured to deliver therapeutic stimulation pulses to the first and second electrodes. Methods and systems include positioning the neurostimulation device for administration of the neurostimulation treatment, whereby the first electrode is disposed on, over or adjacent to auricular branch(es) of the vagus nerve, and the second electrode is disposed on, over or adjacent to branch(es) of the auriculotemporal nerve, and administering the neurostimulation treatment.

Abstract: In an illustrative embodiment, methods and systems for attenuating effect(s) associated with reduction or cessation of substance use by an individual include providing a neurostimulation delivery system including a neurostimulation device having a first portion including at first electrode configured to electrically stimulate branch(s) of the auriculotemporal nerve, and a second portion including a second electrode configured to electrically stimulate auricular branch(es) of the vagus nerve, and a pulse generator including circuitry configured to deliver therapeutic stimulation pulses to the first and second electrodes. Methods and systems include positioning the neurostimulation device for administration of the neurostimulation treatment, whereby the first electrode is disposed on, over or adjacent to branch(s) of the auriculotemporal nerve, and the second electrode is disposed on, over or adjacent to auricular branch(es) of the vagus nerve, and administering the neurostimulation treatment.

Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.

Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.

Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.

Abstract: The invention includes a chimeric antigen receptor (CAR) specific for a natural-killer group 2, member D ligand (NKG2DL), compositions comprising the CAR, polynucleotides encoding the CAR, vectors comprising a polynucleotide encoding the CAR, and recombinant T cells comprising the CAR. The invention also includes methods of making a genetically modified T cell expressing a NKG2D-CAR wherein the expressed CAR comprises a NKG2D extracellular domain. The present invention also relates generally to the use of T cells engineered to express a CAR to treat cancer associated with NKG2D.

Abstract: Systems and methods for treating cognitive dysfunction and/or depression using transcutaneous auricular neurostimulation therapy may include positioning a wearable neurostimulation device about the ear of the patient, connecting the wearable neurostimulation device, to a pulse generator, and delivering a first series of stimulation pulses to at least one first electrode, the first series being configured to increase monoamine neurotransmitter availability, and delivering a second series of stimulation pulses to at least one second electrode, the second series being configured to upregulate opioid receptor agonists.

Abstract: Provided herein is an animal model system and uses thereof. In particular, provided herein is an animal model for Neisseria infection and use of such a model in research and screening applications.

Abstract: The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.

Abstract: Implementations are provided herein for offering partitioned performance within a distributed file system and providing throttling at the granular level. A set of hardware and network resources available to process work items can be determined. A set of resource accounting tokens based on resource records generated when processing work items can be dynamically updated. A granular resource accounting aggregate for a customizable field of data can be selected for throttling, such as a unique user identifier, a unique group identifier, a unique client internet protocol address, a unique file, etc. A granular throttling level can then be established based on a granular throttling policy. In response to the resource accounting aggregate meeting the throttling level, the user, group, internet protocol address, etc. can be throttled at, at least one of, the cluster layer, the node layer or the protocol layer.

Abstract: Implementations are provided herein for offering partitioned performance within a distributed file system and more specifically, for offering adaptive predicted impact of resource consumption by pending work items. Core resource consumption per work item can be estimated prior to processing the work item. When processing the work item, the actual amount of resources used to process the work item can be measured and recorded. The file system can then update future estimates for performing work items based on past results. Resources made available to process future requests can be throttled based on dynamically updated estimates of resource consumption by pending work items.

Abstract: Implementations are provided herein for offering partitioned performance within a distributed file system. Core resource consumption per work item can be tracked independently. Discriminative data already known by the file system surrounding the context of the work item can be used to determine a reference resource accounting specification applicable to the work item. When processing the work item, a detailed resource record can be generated that inventories the resources used in processing the work item. The resource record associated with the work item can be recorded into a set of resource accounting tokens that track activity resource consumption at a granular level. A universal table of resource accounting tokens can be dynamically updated upon the processing of work items and generation of associated resource records throughout the distributed file system.

Abstract: Implementations are provided herein for offering partitioned performance within a distributed file system; specifically, for providing adaptive policies and leases within the partitions. An amount of resources available to a cluster of nodes operating as a distributed file system can be determined and those resources can be apportioned to individual nodes based on hardware profiles of the nodes. A set of resource accounting tokens can be dynamically updated and used as a basis to generate a cluster resource accounting aggregate, a set of node resource accounting aggregates, and a set of protocol resource accounting aggregates. The dynamically updated resource accounting aggregates can then be used to dynamically throttle resource available to process work requests at the cluster, node, and protocol head layers based on policy.

Abstract: Improved methods for extracting lipid-containing molecules from microbes are disclosed. The methods utilize selected surfactants for extraction of lipids and lipopolysaccharides from microbes, such as bacteria and fungi. The extracted lipids and lipopolysaccharides may be used, for example, to identify the source microbe via mass spectroscopy.