Abstract: The present disclosure provides systems and methods which facilitate the prediction of an estimated time in which one or more fluids will optimally be diffused into a biological specimen, e.g., a tissue sample derived from a human subject. In some embodiments, the present disclosure provides systems and methods which facilitate the prediction of an estimated time until a biological specimen will optimally be fixed with one or more fixatives. In other embodiments, the prediction of a future time at which the biological specimen will be optimally fixed is based on time-of-flight data acquired at a particular point in time during the fixation of the biological specimen that has been deemed sufficiently accurate to predict the time at which the biological specimen will be optimally diffused with fixative.

Abstract: Disclosed are systems and methods for labelling one or more morphological markers in a biological sample that are characteristic of one or more molecular features. In particular, system and methods are described for labelling one or more morphological markers in a biological sample with covalently deposited narrow band detectable moieties. Narrow band detectable moiety labelling of the one or more morphological markers permits higher order multiplexed assays due to conservation of available spectral bandwidth. Furthermore, as compared to conventional counterstaining methods, covalent deposition of one or more detectable moieties can provide flexibility and robustness with regard to the order in which biomarkers and morphological markers are labeled in a given staining protocol.

Abstract: The present disclosure is directed to a method of staining a biological specimen (e.g. a single serial tissue section derived from a biological sample) with one or more routine and/or special statins while concomitantly labeling the same biological specimen with one or more detectable moieties without the need for stripping any stain or evaluating different images of stained serial tissue sections of a biological specimen. In some embodiments, the present disclosure is directed to a biological specimen stained with one or more conventional dyes, and where the biological specimen further includes one or more biomarkers labeled with one or more detectable moieties.

Abstract: An electronic storage cabinet and lighted sign assembly for an ATM comprising a hollow cabinet having a box-like frame with a front surface is attached to the ATM with the frame front abutted against the back portion of the ATM. Special equipment support means are provided within the cabinet for supporting, if desired, a modem and/or alarm means. The modem and alarm means may be easily installed and serviced through side openings which are selectively closed off by side doors. In the preferred embodiment of the invention, a pair of posts are provided as vertical extensions to the cabinet for supporting a lighted sign assembly. Special means are provided for securing the cabinet to the backside of the ATM.