Patents by Inventor Daniel R. Draney
Daniel R. Draney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11167046Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: GrantFiled: November 18, 2019Date of Patent: November 9, 2021Assignee: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin, Joy Kovar
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Publication number: 20200085976Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: ApplicationFiled: November 18, 2019Publication date: March 19, 2020Applicant: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin, Joy Kovar
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Publication number: 20200078474Abstract: A composition comprising: a polymorphic form of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-ulfonatobutyl)-3H-indol- 1- ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and an acceptable excipient.Type: ApplicationFiled: November 18, 2019Publication date: March 12, 2020Applicant: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin
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Patent number: 10548991Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: GrantFiled: November 23, 2015Date of Patent: February 4, 2020Assignee: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin
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Patent number: 9408924Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range.Type: GrantFiled: November 24, 2014Date of Patent: August 9, 2016Assignee: LI-COR, INC.Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
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Publication number: 20160144058Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: ApplicationFiled: November 23, 2015Publication date: May 26, 2016Applicant: Ll-COR, INC.Inventors: Daniel R. Draney, WILLIAM M. VOLCHECK, KATIE SCHAEPE, VASSIL ELITZIN, JOY KOVAR
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Patent number: 9089603Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: GrantFiled: March 15, 2013Date of Patent: July 28, 2015Assignee: LI-COR, INC.Inventors: Xinshe Xu, Daniel R. Draney, Mark Cradduck, Lael Cheung, Kousik Kundu, William M. Volcheck
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Publication number: 20150119553Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range.Type: ApplicationFiled: November 24, 2014Publication date: April 30, 2015Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
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Patent number: 8927719Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: GrantFiled: March 14, 2013Date of Patent: January 6, 2015Assignee: Li-Cor, Inc.Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
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Publication number: 20130274452Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: ApplicationFiled: March 14, 2013Publication date: October 17, 2013Inventors: Xinshe Xu, Daniel R. Draney, Lael Cheung
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Patent number: 8481752Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: GrantFiled: June 21, 2010Date of Patent: July 9, 2013Assignee: Li-Cor, Inc.Inventors: Xinshe Xu, Daniel R. Draney
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Publication number: 20130052637Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Applicant: LI-COR, INC.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 8303936Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: GrantFiled: June 15, 2012Date of Patent: November 6, 2012Assignee: Li-Cor, Inc.Inventors: Daniel R. Draney, Ananda G. Lugade, Narasimhachari Narayanan, Joy Kovar, D. Michael Olive
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Publication number: 20120258048Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: June 15, 2012Publication date: October 11, 2012Applicant: LI-COR, INC.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 8227621Abstract: The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.Type: GrantFiled: June 12, 2006Date of Patent: July 24, 2012Assignee: Li-Cor, Inc.Inventors: Xinzhan Peng, Xinshe Xu, Daniel R. Draney, Garrick M. Little, Jiyan Chen, William M. Volcheck, Charles Prescott
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Patent number: 8173445Abstract: The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred embodiment, the method described herein detects individual NTP molecules.Type: GrantFiled: October 31, 2008Date of Patent: May 8, 2012Assignee: Pacific Biosciences of California, Inc.Inventors: John G. K. Williams, Daniel R. Draney
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Publication number: 20100323389Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: ApplicationFiled: June 21, 2010Publication date: December 23, 2010Applicant: LI-COR, INC.Inventors: Xinshe Xu, Daniel R. Draney
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Publication number: 20100080758Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: October 2, 2009Publication date: April 1, 2010Applicant: LI-COR,INC.Inventors: Daniel R. Draney, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 7597878Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: GrantFiled: May 19, 2006Date of Patent: October 6, 2009Assignee: Li-Cor, Inc.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 7504089Abstract: A compound of the formula (I) wherein the variables are defined herein. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.Type: GrantFiled: November 4, 2005Date of Patent: March 17, 2009Assignee: Li-Cor, Inc.Inventors: Ananda G. Lugade, Narasimhachari Narayanan, Daniel R. Draney