Patents by Inventor Daniel R Gentry

Daniel R Gentry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of capturing, detecting and quantifying RNA:DNA hybrids and a modified RNase H useful therein
    Patent number: 7560232
    Abstract: Methods for specific RNA capture, detection and quantification are presented utilizing a protein that selectively binds RNA:DNA hybrids, preferably an RNase H that is modified to reduce degradation of the nucleic acid molecules and enhance specific detection of mixed RNA:DNA nucleic acid hybrids. Labeling of the RNA and/or amplification is not required to perform these methods. Modified RNase H enzymes useful in such methods are disclosed.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: July 14, 2009
    Assignee: Promega Corporation
    Inventors: Richard Carter, Martin Rosenburg, Daniel R. Gentry, Nigel Grinter
  • metRS2
    Patent number: 7304152
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: December 4, 2007
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • metRS2
    Patent number: 7128920
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • tRNA synthetases, metRS
    Patent number: 7087417
    Abstract: The invention relates to metRS polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing metRS polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: August 8, 2006
    Assignee: Replidyne, Inc.
    Inventors: Philip David Hayes, Daniel R Gentry, Stephanie Van Horn
  • Methods of capturing, detecting and quantifying RNA:DNA hybrids and a modified RNase H useful therein
    Publication number: 20040229242
    Abstract: Methods for specific RNA capture, detection and quantification are presented utilizing a protein that selectively binds RNA:DNA hybrids, preferably an RNase H that is modified to reduce degradation of the nucleic acid molecules and enhance specific detection of mixed RNA:DNA nucleic acid hybrids. Labeling of the RNA and/or amplification is not required to perform these methods. Modified RNase H enzymes useful in such methods are disclosed.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 18, 2004
    Inventors: Richard H. Carter, Martin Rosenberg, Daniel R. Gentry, Nigel Grinter
  • metRS2
    Publication number: 20040157233
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Application
    Filed: June 30, 2003
    Publication date: August 12, 2004
    Inventors: Daniel R. Gentry, David J. Holmes, Karen A. Ingraham
  • tRNA synthetases, metRS
    Publication number: 20040014958
    Abstract: The invention relates to metRS polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing metRS polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: June 26, 2003
    Publication date: January 22, 2004
    Applicants: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Philip D. Hayes, Daniel R. Gentry, Stephanie Van Horn