Patents by Inventor Daniel R. Getts

Daniel R. Getts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE-MODIFYING NANOPARTICLES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Publication number: 20200276227
    Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
    Type: Application
    Filed: April 7, 2020
    Publication date: September 3, 2020
    Inventor: Daniel R. GETTS
  • Peptide conjugated particles
    Patent number: 10617747
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: April 14, 2020
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Compositions and Methods for Antigen-Specific Tolerance
    Publication number: 20200046816
    Abstract: The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 13, 2020
    Inventors: Stephen D. Miller, Michael A. Pleiss, Daniel R. Getts, Aaron Martin
  • Modified Immune-Modulating Particles
    Publication number: 20200030369
    Abstract: The current invention involves the surprising finding that when carboxylated particles, such as carboxylated poly-styrene, PLGA, or diamond particles are administered to subjects, inflammatory immune responses are ameliorated. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same carboxylated particles.
    Type: Application
    Filed: October 16, 2019
    Publication date: January 30, 2020
    Inventors: Daniel R. Getts, Rachael Terry, Nicholas King
  • Compositions Comprising Apoptotic Signaling and Methods for Induction of Antigen-Specific Tolerance
    Publication number: 20190365877
    Abstract: The present invention utilizes carrier particles to present antigen peptides and proteins to the immune system in such a way as to induce antigen specific tolerance. The carrier particle is designed in order to trigger an immune tolerance effect. The invention is useful for treatment of immune related disorders such as autoimmune disease, transplant rejection and allergic reactions.
    Type: Application
    Filed: March 19, 2019
    Publication date: December 5, 2019
    Inventors: Stephen D. Miller, Russell L. Bromley, Michael A. Pleiss, Daniel R. Getts, Aaron Martin
  • PARTICLES ENCAPSULATING FUSION PROTEINS CONTAINING LINKED EPITOPES
    Publication number: 20190365656
    Abstract: The present invention provides compositions comprising biodegradable particles that encapsulate two or more epitopes linked together by one or more linkers that are susceptible to cleavage by specific proteases. The present invention further provides methods for inducing antigen-specific tolerance and protective immune responses and for the treatment inflammatory diseases, such as autoimmune diseases, allergies, cancers, or infectious diseases.
    Type: Application
    Filed: January 4, 2017
    Publication date: December 5, 2019
    Inventor: Daniel R. Getts
  • Modified immune-modulating particles
    Patent number: 10471093
    Abstract: The current invention involves the surprising finding that when carboxylated particles, such as carboxylated polystyrene, PLGA, or diamond particles are administered to subjects, inflammatory immune responses are ameliorated. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same carboxylated particles.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: November 12, 2019
    Assignee: Cour Pharmaceuticals Development Company.
    Inventors: Daniel R. Getts, Rachael Terry, Nicholas King
  • COVALENT POLYMER-ANTIGEN CONJUGATED PARTICLES
    Publication number: 20190282707
    Abstract: The present invention provides compositions comprising tolerizing immune modified particles (TIMPs) and methods for using and making said TIMPs. In particular, carrier polymer is covalently conjugated with antigenic peptide before particle formation, which allows for exquisite control of particle size and antigen encapsulation (e.g., for use in eliciting induction of immunological tolerance).
    Type: Application
    Filed: December 22, 2016
    Publication date: September 19, 2019
    Inventors: Ryan Pearson, Daniel R. Getts, John Puisis, James Herrmann
  • Peptide Conjugated Particles
    Publication number: 20190262441
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Application
    Filed: February 11, 2019
    Publication date: August 29, 2019
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick Mccarthy
  • Modified Immune-Modulating Particles
    Publication number: 20190099443
    Abstract: The current invention involves the surprising finding that when carboxylated particles, such as carboxylated polystyrene, PLGA, or diamond particles are administered to subjects, inflammatory immune responses are ameliorated. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same carboxylated particles.
    Type: Application
    Filed: October 3, 2018
    Publication date: April 4, 2019
    Inventors: Daniel R. Getts, Rachael Terry, Nicholas King
  • Immune-Modifying Nanoparticles for the Treatment of Inflammatory Diseases
    Publication number: 20190060354
    Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
    Type: Application
    Filed: March 12, 2018
    Publication date: February 28, 2019
    Inventor: Daniel R. Getts
  • Peptide conjugated particles for the treatment of allergy
    Patent number: 10201596
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: February 12, 2019
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Peptide conjugated particles
    Patent number: 10188711
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: January 29, 2019
    Assignee: Northwestern University
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Peptide Conjugated Particles
    Publication number: 20180271962
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Application
    Filed: March 15, 2018
    Publication date: September 27, 2018
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Immune-modifying nanoparticles for the treatment of inflammatory diseases
    Patent number: 9919005
    Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: March 20, 2018
    Assignee: COUR PHARMACEUTICALS DEVELOPMENT COMPANY, INC.
    Inventor: Daniel R. Getts
  • PEPTIDE CONJUGATED PARTICLES
    Publication number: 20170312349
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Application
    Filed: March 8, 2017
    Publication date: November 2, 2017
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick P. McCarthy, Jr.
  • PEPTIDE CONJUGATED PARTICLES
    Publication number: 20170258880
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Application
    Filed: November 2, 2016
    Publication date: September 14, 2017
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • IMMUNE-MODIFYING NANOPARTICLES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Publication number: 20170173071
    Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
    Type: Application
    Filed: November 2, 2016
    Publication date: June 22, 2017
    Inventor: Daniel R. GETTS
  • Peptide conjugated particles
    Patent number: 9616113
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: April 11, 2017
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Peptide conjugated particles
    Patent number: 9522180
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: December 20, 2016
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy