Abstract: The present application relates to a system (10) for anatomical reduction of bone fractures in which first and second manipulators (12, 14), and optionally a third manipulator (16), are attached to fragments of the fracture to be reduced by percutaneous attachment devices such as Schanz pins. An underlying processing system determines, from one or more medical images of the fracture, manipulations such as rotations and translations of the bone fragments required to correctly reposition and align the fragments for optimum healing of the fracture. The processing system provides motion reference signals (position, speed, acceleration and force) for a controller, which in turn causes the first, second and third manipulators (12, 14, 16) to effect the calculated manipulations.