Patents by Inventor Daniel Rauh

Daniel Rauh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kinase inhibitors and their use in cancer therapy
    Patent number: 10550114
    Abstract: The present invention relates to a 2,3-diphenyl-1,6-naphthyridine-5-one derivative according to general formula (I), and the use of the 2,3-diphenyl-1,6-naphthyridine-5-one derivative in the diagnosis or treatment of cancer.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: February 4, 2020
    Assignee: TECHNISCHE UNIVERSITÄT DORTMUND
    Inventors: Daniel Rauh, Rajesh Gontla, Jörn Weisner
  • KINASE INHIBITORS AND THEIR USE IN CANCER THERAPY
    Publication number: 20180354941
    Abstract: The present invention relates to a 2,3-diphenyl-1,6-naphthyridine-5-one derivative according to general formula (I), and the use of the 2,3-diphenyl-1,6-naphthyridine-5-one derivative in the diagnosis or treatment of cancer.
    Type: Application
    Filed: May 3, 2016
    Publication date: December 13, 2018
    Applicant: TECHNISCHE UNIVERSITÄT DORTMUND
    Inventors: Daniel Rauh, Rajesh Gontla, Jörn Weisner
  • DEVELOPMENT OF FLUORESCENTLY P-LOOP LABELLED KINASES FOR SCREENING OF INHIBITORS
    Publication number: 20120107836
    Abstract: The present invention relates to a kinase labelled at an amino acid naturally present or introduced in the P-loop of said kinase, wherein said labelling is effected at a free thiol or amino group of said amino acid and said label is (a) a thiol- or amino-reactive fluorophore sensitive to polarity changes in its environment; or (b) a thiol-reactive spin label, an isotope or an isotope-enriched thiol- or amino-reactive label, such that said fluorophore, spin label, isotope or isotope-enriched label does not inhibit the catalytic activity and does not interfere with the stability of the kinase. The invention furthermore relates to a method of screening for kinase inhibitors, a method of determining the kinetics of ligand binding and/or of dissociation of a kinase inhibitor and a method of generating mutated kinases suitable for the screening of kinase inhibitors using the kinase of the present invention.
    Type: Application
    Filed: October 13, 2011
    Publication date: May 3, 2012
    Inventors: Daniel Rauh, Jeffrey Raymond Simard
  • Fluorescently Or Spin-Labeled Kinases For Rapid Screening And Identification Of Novel Kinase Inhibitor Scaffolds
    Publication number: 20110212475
    Abstract: The present invention relates to a kinase labeled at an amino acid having a free thiol or amino group, wherein said amino acid is naturally present or introduced in the activation loop of said kinase, with (a) a thiol- or amino-reactive fluorophore sensitive to polarity changes in its environment; or (b) a thiol-reactive spin label, an isotope or an isotope-enriched thiol- or amino-reactive label, such that said fluorophore, spin label, isotope or isotope-enriched label does not inhibit the catalytic activity and does not interfere with the stability of the kinase. The invention furthermore relates to a method of screening for kinase inhibitor, a method of determining the kinetics of ligand binding and/or of dissociation of a kinase inhibitor and a method of generating mutated kinases suitable for the screening of kinase inhibitors using the kinase of the present invention.
    Type: Application
    Filed: January 21, 2011
    Publication date: September 1, 2011
    Inventors: Daniel Rauh, Jeffrey Raymond Simard, Matthäus Getlik