Abstract: Systems and methods for providing a client-side configurable graphical control element framework are disclosed. In one embodiment, a system may include a client device that may execute a user interface and a data services component in communication with the client device and a data source. The user interface may retrieve a graphical control element configuration file and may transmit a request for data, including a metric identifier, to the data services component. The data services component may retrieve a data services configuration file for the metric identifier, and may request data from the data source based on the data services configuration file. The data services component receives data from the data source and formats the data according to the data services configuration file. The user interface may receive the formatted data and represent the data as a graphical control element according to the graphical control element configuration file.

Abstract: A neckliner for a helmet incorporates a C-shaped body for fitting in the helmet around the back and sides of a neck of a wearer. The C-shaped body has a first end and a second end, a speaker for relaying sound to an ear of the wearer, a releasable fastener for releasably attaching the neckliner to the helmet, a first support portion and a second support portion. Each support portion has a proximal end and a distal end. The proximal end of the first support portion is attached to the first end of the C-shaped body. The proximal end of the second support portion is attached to the second end of the C-shaped body. The speaker is situated in a first corner formed between the first end of the C-shaped body and the first support portion for placement proximal to a first ear of the wearer in use.

Abstract: A compound of formula (I) for use in the prevention or treatment of a bacterial infection wherein: PX is selected from the group consisting of (P1), (P2) and (P3).

Abstract: A goggle for use in snowsports including a flexible frame and a lens assembly, magnets or magnetic elements being provided on upper and lower edges of an inner surface of the lens assembly and magnets or magnetic elements being provided in corresponding positions on an outer surface of the frame, for releasably holding the lens assembly in the frame, and at least two releasable clips being provided on the frame, the clips being movable between a released position and an engaged position, the clips in the engaged position overlying a portion of the lens assembly and each clip including at least one retaining member which in use passes into an aperture at least part way through the lens assembly, in a direction substantially perpendicular to the surface of the lens assembly, for preventing or limiting movement of the lens assembly in a direction away from the lateral side of the frame.

Abstract: A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.

Abstract: A goggle for use in snowsports including a flexible frame and a lens assembly, magnets or magnetic elements being provided on upper and lower edges of an inner surface of the lens assembly and magnets or magnetic elements being provided in corresponding positions on an outer surface of the frame, for releasably holding the lens assembly in the frame, and at least two releasable clips being provided on the frame, the clips being movable between a released position and an engaged position, the clips in the engaged position overlying a portion of the lens assembly and each clip including at least one retaining member which in use passes into an aperture at least part way through the lens assembly, in a direction substantially perpendicular to the surface of the lens assembly, for preventing or limiting movement of the lens assembly in a direction away from the lateral side of the frame.

Abstract: A series of substituted [1,3,5]triazin-2-yl derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of quinoline derivatives, substituted by an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings attached via an alkylene chain optionally linked to a heteroatom, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of amino-substituted fused pyridine and pyrazine derivatives, in particular amino-substituted quinoline and quinoxaline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula

Abstract: A series of quinoline and quinoxaline derivatives, substituted by an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings attached via an alkylene chain optionally linked to a heteroatom, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of substituted pyrazolo[1,5-?][1,3,5]triazine and pyrazolo[1,5-?j-pyrimidine derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. Formula (I).

Abstract: A series of amino-substituted fused pyridine and pyrazine derivatives, in particular amino-substituted quinoline and quinoxaline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of substituted [1,3,5]triazin-2-yl derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A billet strap for use with a Western saddle includes a portion of stretch material in the construction of the billet strap. The stretch material allows the billet strap to adjust and fine tune the tension of a cinch when the billet strap is used to connect the cinch to the Western saddle, thus increasing the comfort of the horse. In one exemplary embodiment, the billet strap is comprised of a portion of nonstretching material joined in series with a portion of stretching material. The billet strap may include a protective sleeve. The protective sleeve may cover all or only a portion of the billet strap. In other embodiments of the invention, the billet strap is comprised of multiple portions of material (e.g., three nonstretching portions joined together by two stretching portions). In yet another embodiment, the billet strap is comprised entirely of a stretching material.

Abstract: A conveying apparatus for workpieces during a manufacturing procedure has a fixed guide track and a guide track having a variable geometry. The variable guide track includes a plurality of sections movable relative to the fixed guide track. The displacement of the movable sections of the variable guide track alters the distance between carriers arranged on a continuous conveyor chain in the region in which workpieces are transferred from a feed belt to a discharge belt.