Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Wipes dispensing systems are disclosed herein. The wipes dispensing system may include an inverted dockable wipes container with a wipes dispesing mechanism configured to rest upside-down on a dock. This wipes dispensing system allows excess cleaning solvent to be contained in the reservoir of the dock. The wipes dispensing system may include a wipes dispensing and cleaning system configured as a dockable wiping handle and a base for housing a stack of individual wipes. This wipes dispensing and cleaning system allows the user to selectively use a wipe without directly contacting the wipes or any solvent/cleaning agent via the user's hands.

Abstract: A binder comprising a detachable article holder is described. The article holder comprises hangers that may be extended to detach the article holder from the binder and/or configure the article holder for hanging on support rails. Also described is a method of extending hangers of the article holder to both detach the article holder from the binder shell and configure the article holder for hanging.

Abstract: An apparatus and method are disclosed to digitize an input electrical signal. A sequence of nonuniformly spaced optical pulses impinges an optical modulator, where the pulses are modulated by the electrical input signal, the optical pulses being detected by one or more photoreceivers, the photoreceiver outputs being electrically sampled in analog-to-digital converters and then processed in a digital signal processor (DSP) in order to measure the electrical input signal. The series of nonuniform pulses are formed by interleaving L uniformly spaced pulse streams each of repetition period T and where fmax, the maximum allowable spectral frequency of the input electrical signal, is greater than 4·L·f/2, where f=1/T.

Abstract: A method of digitizing an analog electrical signal combines optical and electronic techniques in order to improve the resolution, sampling rate, input frequency range, or flexibility. It implements an optical interferometric modulator, which modulates an input optical signal by the input electrical signal combined with a calibration signal. A set of two or more photoreceivers receiving the output optical signals from the optical modulator produce output electrical signals, which are digitized and processed in a DSP to produce a digitized version of the electrical input signal, and a digitized calibration signal value is used to optimize the input electrical signal digitization. The method and the device can be used in many fields including instrumentation, communications, and imaging.

Abstract: An apparatus and method are disclosed to digitize an input electrical signal. A sequence of nonuniformly spaced optical pulses impinges an optical modulator, where the pulses are modulated by the electrical input signal, the optical pulses being detected by one or more photoreceivers, the photoreceiver outputs being electrically sampled in analog-to-digital converters and then processed in a digital signal processor (DSP) in order to measure the electrical input signal. The series of nonuniform pulses are formed by interleaving L uniformly spaced pulse streams each of repetition period T and where fmax, the maximum allowable spectral frequency of the input electrical signal, is greater than 4·L·f/2, where f=1/T.

Abstract: A method of digitizing an analog electrical signal combines optical and electronic techniques in order to improve the resolution, sampling rate, input frequency range, or flexibility. It implements an optical interferometric modulator, which modulates an input optical signal by the input electrical signal combined with a calibration signal. A set of two or more photoreceivers receiving the output optical signals from the optical modulator produce output electrical signals, which are digitized and processed in a DSP to produce a digitized version of the electrical input signal, and a digitized calibration signal value is used to optimize the input electrical signal digitization. The method and the device can be used in many fields including instrumentation, communications, and imaging.