Patents by Inventor DANIEL REKER

DANIEL REKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EX VIVO TISSUE EXPLANT AND GRAFT PLATFORM AND USES THEREOF
    Publication number: 20230101335
    Abstract: An ex vivo tissue composition comprising an isolated tissue explant and tissue graft is provided. Methods of making and using the tissue composition are also provided.
    Type: Application
    Filed: May 6, 2022
    Publication date: March 30, 2023
    Inventors: Carlo Giovanni Traverso, Yunhua Shi, Vance Soares, Daniel Reker, Robert S. Langer
  • BRANCHED POLY(-AMINO ESTERS) FOR THE DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220287983
    Abstract: The present disclosure provides branched poly(?-amino esters) (PBAEs) of Formula (I) made by reacting primary amines with diacrylates. Further provided herein are compositions comprising the polymers of Formula (I), and methods of using the compositions and polymers as described herein for the treatment of disease.
    Type: Application
    Filed: March 8, 2022
    Publication date: September 15, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Ameya R. Kirtane, Robert S. Langer, Hyunjoon KIM, Gary W. Liu, James Byrne, Daniel Reker, Yunhua Shi, Grace Junyue Zhong, Netra Rajesh
  • Poly(Beta-Thioester) Polymers and Polymeric Nanoparticles
    Publication number: 20220175938
    Abstract: The disclosure describes poly(?-thioester) polymers and polymeric nanoparticles, pharmaceutical compositions comprising these materials, their use in the treatment of cancer and infectious disease, and machine learning methods for identifying and selecting them.
    Type: Application
    Filed: July 31, 2020
    Publication date: June 9, 2022
    Inventors: ROBERT LANGER, CARLO TRAVERSO, AMEYA KIRTANE, DANIEL REKER, LEWIS SCOTT JONES, HYUNJOON KIM, NETRA RAJESH
  • METHODS AND COMPOSITIONS FOR INVESTIGATING MULTIPLE DRUG-DRUG TRANSPORTER INTERACTIONS
    Publication number: 20210231645
    Abstract: Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided.
    Type: Application
    Filed: December 10, 2020
    Publication date: July 29, 2021
    Inventors: Robert S. LANGER, Carlo Giovanni TRAVERSO, Yunhua SHI, Vance SOARES, Daniel REKER
  • METHODS OF AVOIDING EXCIPIENT-BASED ADVERSE EFFECTS AND OF EXPLOITING BIOLOGICAL PROPERTIES OF GRAS COMPOUNDS
    Publication number: 20200297671
    Abstract: This invention relates to methods of selecting or tailoring a therapeutic for an individual subject, reducing the excipient burden in a subject, and identifying adverse reaction-associated inactive ingredients in a subject being administered multiple drugs. The invention also relates to methods of inhibiting UGT2B7 activity or P-gp activity, methods of treating a subject via co-administration of a UGT2B7 inhibitor or a P-gp inhibitor, and pharmaceutical compositions comprising gum rosin, abietic acid, or vitamin A palmate.
    Type: Application
    Filed: February 27, 2020
    Publication date: September 24, 2020
    Inventors: ROBERT LANGER, CARLO TRAVERSO, DANIEL REKER, STEVEN BLUM
  • High Capacitance Electrolytic Capacitor Foil, Method for Production Thereof and Electrolytic Capacitor
    Publication number: 20080074828
    Abstract: Capacitor foil includes a core layer, at least one porous layer and a porous surface layer, and a method for producing the same and an electrolytic capacitor. The at least one porous layer and the porous surface layer are porous as a result of a first DC-pulse etching process step. The method includes at least one further etching step in which the etching fluid of the first etching process step in the at least one porous layer and the porous surface layer is modified into or replaced by a filling substance having a low etching capability, at least the porous surface layer of the foil is further etched to increase the porosity of the porous surface layer, and the filling substance is removed from the foil.
    Type: Application
    Filed: March 8, 2004
    Publication date: March 27, 2008
    Inventors: Hendrik Arlen Post, Alexander Gerard Daniel Rekers