Patents by Inventor Daniel Robert Gentry

Daniel Robert Gentry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FabH
    Patent number: 6682919
    Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: January 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine Debouck, Daniel Robert Gentry, Deborah Dee Jaworski, John Timothy Londsdale, Jeffrey L Mooney, David John Payne, Stewart Campbell Pearson, Lisa Kathleen Schilling, Glenn Scott Van Aller, Min Wang, Yi Yi Zhong
  • TrpS
    Patent number: 6416976
    Abstract: The invention provides trpS polypeptides and DNA (RNA) encoding trpS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trpS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: July 9, 2002
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • Novel greA
    Publication number: 20020058308
    Abstract: The invention provides greA polypeptides and DNA (RNA) encoding greA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing greA polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 26, 2001
    Publication date: May 16, 2002
    Inventors: Rebecca Claire Greenwood, Daniel Robert Gentry
  • Spo-rel
    Patent number: 6365159
    Abstract: spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: April 2, 2002
    Inventors: Martin Karl Russel Burnham, Daniel Robert Gentry, John Edward Hodgson, Elizabeth Jane Lawlor
  • Tryptophenyl tRNA synthetase from Streptococcus pneumoniae
    Patent number: 6346409
    Abstract: The invention provides trpS polypeptides and DNA (RNA) encoding trpS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trpS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: February 12, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • Spo-rel from streptococcus pneumoniae
    Patent number: 6268179
    Abstract: The invention provides spo/rel polypeptides and DNA (RNA) encoding spo/rel polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo/rel polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Daniel Robert Gentry
  • FabD
    Patent number: 6258934
    Abstract: FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the treatment of infection, particularly bacterial infections. Antagonists against such FabD and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FabD nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Fab (Fatty acid biosynthesis) and for detecting the polypeptide in a host.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, David John Payne, Stewart Campbell Pearson, John Timothy Lonsdale
  • GreA from Staphylococcus aureus
    Patent number: 6210674
    Abstract: The invention provides greA polypeptides and DNA (RNA) encoding greA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing greA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: April 3, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, plc.
    Inventors: Rebecca Claire Greenwood, Daniel Robert Gentry
  • DNA encoding SPO/REL polypeptides of streptococcus
    Patent number: 6096518
    Abstract: The invention provides spo/rel polypeptides and DNA (RNA) encoding spo/rel polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo/rel polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: August 1, 2000
    Assignee: Smithkline Beecham Corporation
    Inventor: Daniel Robert Gentry
  • Tryptophanyl tRNA synthetase, trpS, of Streptococcus pneumoniae
    Patent number: 6046174
    Abstract: The invention provides trpS polypeptides and DNA (RNA) encoding trpS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trpS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • Histidyl tRNA synthetase from Streptococcus pneumoniae
    Patent number: 6040162
    Abstract: The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: March 21, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • Nucleic acid encoding greA from Streptococcus pneumoniae
    Patent number: 6022710
    Abstract: greA polypeptides and DNA (RNA) encoding such greA and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such greA for the treatment of infection, particularly bacterial infections. Antagonists against such greA and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of greA nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding greA/greB gene family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: February 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Daniel Robert Gentry
  • DNA encoding spo-rel polypeptides
    Patent number: 5989864
    Abstract: Spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: November 23, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Martin Karl Russel Burnham, Daniel Robert Gentry, John Edward Hodgson, Elizabeth Jane Lawlor
  • DNA encoding seryl t-RNA synthetase
    Patent number: 5968777
    Abstract: The invention provides serS polypeptides and DNA (RNA) encoding serS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing serS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • FabH
    Patent number: 5885572
    Abstract: The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: March 23, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, John Timothy Lonsdale, David John Payne, Stewart Campbell Pearson
  • GreA
    Patent number: 5866368
    Abstract: The invention provides greA polypeptides and DNA (RNA) encoding greA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing greA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: February 2, 1999
    Assignee: Smithkline Beechman Corporation
    Inventors: Rebecca Claire Greenwood, Daniel Robert Gentry
  • Asparaginyl TRNA synthetase polynucleotides of streptococcus
    Patent number: 5834276
    Abstract: The invention provides asnS polypeptides and DNA (RNA) encoding asnS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing asnS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: November 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • FabD polynucleotides
    Patent number: 5827689
    Abstract: FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the treatment of infection, particularly bacterial infections. Antagonists against such FabD and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FabD nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Fab (Fatty acid biosynthesis) and for detecting the polypeptide in a host.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: October 27, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, David John Payne, Stewart Campbell Pearson, John Timothy Lonsdale
  • DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae
    Patent number: 5795758
    Abstract: The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: August 18, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, Rebecca Claire Greenwood, Elizabeth Jane Lawlor
  • FabH
    Patent number: 5783432
    Abstract: The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: July 21, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Daniel Robert Gentry, John Timothy Lonsdale, David John Payne, Stewart Campbell Pearson