Patents by Inventor Daniel Roseman

Daniel Roseman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified mRNA Encoding a Glucose 6 Phosphatase and Uses Thereof
    Publication number: 20200179494
    Abstract: Described herein are methods and compositions for treating a glucose 6 phosphatase deficiency based on mRNA therapy.
    Type: Application
    Filed: July 24, 2018
    Publication date: June 11, 2020
    Inventors: Jeremiah Farelli, Daniel Roseman, Romesh R. Subramanian
  • Characterization of lysosomal enzymes by capillary zone electrophoresis
    Patent number: 10023901
    Abstract: The present invention provides, among other things, methods for the characterization of recombinant Heparan N-Sulfatase (HNS) during manufacture. The present invention uses capillary zone electrophoresis to determine the charge profile, isoform distribution, and/or glycan profile of recombinant HNS; and represents a quality feature for the batch consistency, storage stability, biological half-life, pharmacokinetic, pharmacodynamic and biological activity of the enzyme. In particular, such characterization methods may be beneficial to optimize conditions and ensure consistency for the manufacture of HNS for the treatment of a patient diagnosed with Sanfilippo syndrome using enzyme replacement therapy.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: July 17, 2018
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventor: Daniel Roseman
  • Device to alert drivers to the possibility of forgetting objects in vehicle
    Patent number: 9547976
    Abstract: A device designed to help people from forgetting objects in vehicles. The device includes a central unit, a power cable, and a conducting insert that closes a circuit. The central unit includes a. case that houses the circuit with an internal power source, a buzzer, a switch, and a relay. The circuit is disconnected and when the conducting insert is inserted, it bridges the switch and completes the circuit. The power cable has a plug on one end and a car charger plug on the other. When the vehicle is running and the car charger plug is plugged into the cigarette charger socket, the plug is powered. When the plug is plugged into the relay in powering mode, the circuit is opened. If the plug is in non-powering mode, the relay will remained closed and the circuit will remain completed at this point.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: January 17, 2017
    Inventors: Bruce Roseman, Daniel Roseman
  • Device to Alert Drivers to the Possibility of Forgetting Objects in Vehicle
    Publication number: 20160379467
    Abstract: A device designed to help people from forgetting objects in vehicles. The device includes a central unit, a power cable, and a conducting insert that closes a circuit. The central unit includes a. case that houses the circuit with an internal power source, a buzzer, a switch, and a relay. The circuit is disconnected and when the conducting insert is inserted, it bridges the switch and completes the circuit. The power cable has a plug on one end and a car charger plug on the other. When the vehicle is running and the car charger plug is plugged into the cigarette charger socket, the plug is powered. When the plug is plugged into the relay in powering mode, the circuit is opened. If the plug is in non-powering mode, the relay will remained closed and the circuit will remain completed at this point.
    Type: Application
    Filed: June 26, 2015
    Publication date: December 29, 2016
    Applicant: MORALEX LLC
    Inventors: Bruce Roseman, Daniel Roseman
  • METHOD OF CHARACTERIZING LYSOSOMAL ENZYMES
    Publication number: 20160362719
    Abstract: The present invention provides, among other things, methods for the characterization of recombinant Heparan N-Sulfatase (HNS) during manufacture. The present invention uses capillary zone electrophoresis to determine the charge profile, isoform distribution, and/or glycan profile of recombinant HNS; and represents a quality feature for the batch consistency, storage stability, biological half-life, pharmacokinetic, pharmacodynamic and biological activity of the enzyme. In particular, such characterization methods may be beneficial to optimize conditions and ensure consistency for the manufacture of HNS for the treatment of a patient diagnosed with Sanfilippo syndrome using enzyme replacement therapy.
    Type: Application
    Filed: February 10, 2016
    Publication date: December 15, 2016
    Inventor: Daniel Roseman
  • Method of analyzing the charge profile of heparan N-sulfatase
    Patent number: 9290793
    Abstract: The present invention provides, among other things, methods for the characterization of recombinant Heparan N-Sulfatase (HNS) during manufacture. The present invention uses capillary zone electrophoresis to determine the charge profile, isoform distribution, and/or glycan profile of recombinant HNS; and represents a quality feature for the batch consistency, storage stability, biological half-life, pharmacokinetic, pharmacodynamic and biological activity of the enzyme. In particular, such characterization methods may be beneficial to optimize conditions and ensure consistency for the manufacture of HNS for the treatment of a patient diagnosed with Sanfilippo syndrome using enzyme replacement therapy.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 22, 2016
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventor: Daniel Roseman
  • METHOD OF CHARACTERIZING LYSOSOMAL ENZYMES
    Publication number: 20140294800
    Abstract: The present invention provides, among other things, methods for the characterization of recombinant Heparan N-Sulfatase (HNS) during manufacture. The present invention uses capillary zone electrophoresis to determine the charge profile, isoform distribution, and/or glycan profile of recombinant HNS; and represents a quality feature for the batch consistency, storage stability, biological half-life, pharmacokinetic, pharmacodynamic and biological activity of the enzyme. In particular, such characterization methods may be beneficial to optimize conditions and ensure consistency for the manufacture of HNS for the treatment of a patient diagnosed with Sanfilippo syndrome using enzyme replacement therapy.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 2, 2014
    Applicant: Shire Human Genetic Therapies, Inc.
    Inventor: Daniel Roseman