Abstract: A dental jacket made of a hard, solvent free, substantially non-hydrophilic polyurethane elastomer. The jacket elastomer has a hardness of not less than about Shore D65. A polyester or polyether polyol with a functionality greater than two and a molecular weight greater than one hundred is reacted with an isocyanate prepolymer prepared from one or more branched polyester or polyether polyols with a functionality greater than two; and then blending prepolymer and first polyester or polyether polyol with nanoparticles. In one embodiment, the polypropylene glycol triether and the isocyanate prepolymer comprises dicyclohexylmethane 4,4?-diisocyanate.

Abstract: A method of making a machinable puck of a hard, solvent free, substantially non-hydrophilic polyurethane elastomer for use in fabricating dental appliances. The elastomer has a hardness of not less than about Shore D65. A first polyester or polyether polyol with a functionality greater than two and a molecular weight greater than one hundred is reacted with an isocyanate prepolymer prepared from one or more branched polyester or polyether polyols with a functionality greater than two; and then blending prepolymer and first polyester or polyether polyol with nanoparticles and colorants as needed. In one embodiment, the polypropylene glycol triether and the isocyanate prepolymer comprises dicyclohexylmethane 4,4?-diisocyanate. The machined, elastomer appliance is able to be heated in hot water to make it flexible and formable for individual, customed-fitting for the patient.

Abstract: A hard, solvent free, substantially non-hydrophilic polyurethane elastomer for use in making dental appliances. The elastomer has a hardness of not less than about Shore D65. A polyether or polyester polyol with a functionality greater than two and a molecular weight greater than one hundred is reacted with an isocyanate prepolymer prepared from one or more branched polyether or polyester polyols with a functionality greater than two; and then blending prepolymer and first polyether or polyester polyol with nanoparticles. In one embodiment, the polypropylene glycol triether and the isocyanate prepolymer comprises dicyclohexylmethane 4,4?-diisocyanate.

Abstract: For an accuracy scoring game having a target area towards which steel washers are tossed when playing, a telescopic retrieving pole of multiple sections capable of collapsing into one another for closure and storage and of extending from one another for opening, including a first end for player hand grasping and a second opposite end forming a first compartment of one or more embedded magnets for picking up steel washers from the ground, and in which the retrieving pole, when collapsed, is of a dimension to fit within a carry box for the target area and for the steel washers when the game is not being played.

Abstract: For an accuracy scoring game having a target area towards which steel washers are tossed when playing, a telescopic retrieving pole of multiple sections capable of collapsing into one another for closure and storage and of extending from one another for opening, including a first end for player hand grasping and a second opposite end forming a first compartment of one or more embedded magnets for picking up steel washers from the ground, and in which the retrieving pole, when collapsed, is of a dimension to fit within a carry box for the target area and for the steel washers when the game is not being played.

Abstract: The present invention relates to the use of an inhibitor of the expression or activity of the GM3 synthase gene for the treatment of microvascular complications of diabetes, and to a method of screening compounds useful in the treatment and/or prevention of these complications.

Abstract: The invention relates to an isolated human nucleic acid, characterized in that it corresponds to the promoter of the human FATP5 protein, and to an isolated human nucleic acid coding for a protein, particularly for the human FATP5 protein, placed under the dependence of said promoter. The invention further relates to a vector comprising said nucleic acid, or to a host cell into which said nucleic acid or said vector has been introduced. Finally, the invention relates to the use of said nucleic acid, said vector or said host cell in a method of identifying a product capable of modulating the expression of a nucieotide sequence placed under the dependence of said promoter of the human FATP5 protein, and to said method of identification.

Abstract: Described are compound of the formula (I) defined herein which are useful, for example, in the treatment of diabetes. Also described is a method for preparing the compounds.