Patents by Inventor Daniel Ryan GARALDE

Daniel Ryan GARALDE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DELIVERING AN ANALYTE TO TRANSMEMBRANE PORES
    Publication number: 20240124915
    Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.
    Type: Application
    Filed: February 17, 2023
    Publication date: April 18, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
  • METHOD
    Publication number: 20240076729
    Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.
    Type: Application
    Filed: June 18, 2021
    Publication date: March 7, 2024
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Rebecca Victoria Bowen, Clive Gavin Brown, Mark John Bruce, Daniel Ryan Garalde, James Edward Graham, Andrew John Heron, Etienne Raimondeau, James White, Christopher Peter Youd
  • METHODS FOR DELIVERING AN ANALYTE TO TRANSMEMBRANE PORES
    Publication number: 20230357821
    Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.
    Type: Application
    Filed: February 17, 2023
    Publication date: November 9, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
  • A METHOD OF SELECTIVELY CHARACTERISING A POLYNUCLEOTIDE USING A DETECTOR
    Publication number: 20230295712
    Abstract: The invention provides a method of selectively characterising polynucleotides of a desired property, such as length, using a nanopore, based on the translocation of the polynucleotide through or across the nanopore. Kits and systems for use in such methods are also provided. The methods of the invention are particularly suitable for sequencing polynucleotides such as DNA.
    Type: Application
    Filed: June 18, 2021
    Publication date: September 21, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Rebecca Victoria Bowen, Clive Gavin Brown, Mark John Bruce, Daniel Ryan Garalde, James Edward Graham, Andrew John Heron, Etienne Raimondeau, James White, Christopher Peter Youd
  • METHOD
    Publication number: 20230227903
    Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 20, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Rebecca Victoria Bowen, Clive Gavin Brown, Mark John Bruce, Daniel Ryan Garalde, James Edward Graham, Andrew John Heron, Etienne Raimondeau, James White, Christopher Peter Youd
  • ENZYME STALLING METHOD
    Publication number: 20230212665
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.
    Type: Application
    Filed: December 14, 2022
    Publication date: July 6, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
  • Methods for delivering an analyte to transmembrane pores
    Patent number: 11613771
    Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: March 28, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
  • Enzyme stalling method
    Patent number: 11560589
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: January 24, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White
  • METHOD FOR NANOPORE RNA CHARACTERISATION
    Publication number: 20230012471
    Abstract: The invention relates to a new method of characterising a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.
    Type: Application
    Filed: April 30, 2021
    Publication date: January 12, 2023
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
  • METHOD OF NANOPORE SEQUENCING OF CONCATENATED NUCLEIC ACIDS
    Publication number: 20220090192
    Abstract: The invention relates to a new method of characterising two or more target polynucleotides using a pore. The method involves sequentially attaching to a first polynucleotide one or more subsequent polynucleotides to form a concatenated polynucleotide.
    Type: Application
    Filed: July 19, 2021
    Publication date: March 24, 2022
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, Daniel Ryan Garalde, James White
  • METHOD FOR NANOPORE RNA CHARACTERISATION
    Publication number: 20210395811
    Abstract: The invention relates to a new method of characterising a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.
    Type: Application
    Filed: April 30, 2021
    Publication date: December 23, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
  • Method of nanopore sequencing of concatenated nucleic acids
    Patent number: 11098355
    Abstract: The invention relates to a new method of characterising two or more target polynucleotides using a pore. The method involves sequentially attaching to a first polynucleotide one or more subsequent polynucleotides to form a concatenated polynucleotide.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: August 24, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, Daniel Ryan Garalde, James White
  • Method for nanopore RNA characterisation
    Patent number: 11021747
    Abstract: The invention relates to a new method of characterising a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: June 1, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
  • METHODS FOR DELIVERING AN ANALYTE TO TRANSMEMBRANE PORES
    Publication number: 20210147904
    Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.
    Type: Application
    Filed: June 16, 2020
    Publication date: May 20, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
  • Methods for delivering an analyte to transmembrane pores
    Patent number: 10760114
    Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: September 1, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
  • Methods for delivering an analyte to transmembrane pores
    Patent number: 10724073
    Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: July 28, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Clive Gavin Brown, Daniel Ryan Garalde, Andrew John Heron, Daniel John Turner, James White
  • METHOD FOR NANOPORE RNA CHARACTERISATION
    Publication number: 20200063199
    Abstract: The invention relates to a new method of characterising a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.
    Type: Application
    Filed: September 19, 2019
    Publication date: February 27, 2020
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
  • METHOD OF NANOPORE SEQUENCING OF CONCATENATED NUCLEIC ACIDS
    Publication number: 20200010887
    Abstract: The invention relates to a new method of characterising two or more target polynucleotides using a pore. The method involves sequentially attaching to a first polynucleotide one or more subsequent polynucleotides to form a concatenated polynucleotide.
    Type: Application
    Filed: May 25, 2017
    Publication date: January 9, 2020
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, Daniel Ryan Garalde, James White Oxford
  • Method for nanopore RNA characterisation
    Patent number: 10480026
    Abstract: The invention relates to a new method of characterizing a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNA polynucleotide has been modified to increase DNA helicase binding thereto.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: November 19, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Daniel Ryan Garalde, Andrew John Heron, Lakmal Jayasinghe, Daniel John Turner, James White
  • ENZYME STALLING METHOD
    Publication number: 20190211390
    Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.
    Type: Application
    Filed: January 9, 2019
    Publication date: July 11, 2019
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, David Antoni Alves, James Anthony Clarke, Marion Louise Crawford, Daniel Ryan Garalde, Graham Hall, Daniel John Turner, James White