Patents by Inventor Daniel S. Greenspan

Daniel S. Greenspan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for treating a fibrotic disorder comprising an inhibitor of a BMP-1-like protein
    Patent number: 7888313
    Abstract: ?2-macroglobulin-related agents for treating or preventing a fibrotic disorder associated with fibrillogenesis are disclosed along with methods for using the agents, as well as methods for producing agents suited for use in the disclosed methods for treating or preventing a fibrotic disorder.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: February 15, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel S Greenspan, Yue Zhang, Gaoxiang Ge
  • METHOD FOR MODULATING ATHEROSCLEROSIS
    Publication number: 20100136035
    Abstract: Immunoreactivity to collagen V is associated with development of atherosclerosis. Methods disclosed herein for modulating atherosclerosis and reducing an effect thereof, involve inducing immunological tolerance to collagen V. Methods for evaluating a risk of an individual to develop atherosclerosis and methods for diagnosing atherosclerosis are disclosed herein.
    Type: Application
    Filed: November 20, 2009
    Publication date: June 3, 2010
    Inventors: Daniel S. Greenspan, William J. Burlingham
  • Metalloprotease activation of myostatin, and methods of modulating myostatin activity
    Patent number: 7572599
    Abstract: It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: August 11, 2009
    Assignees: The Johns Hopkins University School of Medicine, Wisconsin Alumni Research Foundation, Wyeth
    Inventors: Se-Jin Lee, Alexandra C. McPherron, Daniel S. Greenspan, William N. Pappano, Neil Wolfman, Kathy Tomkinson
  • Mammalian pro-&agr;3(V) collagen chain genes
    Patent number: 6759528
    Abstract: Mammalian &agr;3(V) pro-collagen and collagen polypeptides and variants thereof are encoded by exemplified polynucleotides. Investigative, diagnostic and therapeutic methods employ the polypeptides, polynucleotides and related materials, such as antibodies, sense- or antisense oligonucleotides and polynucleotides, and the like.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: July 6, 2004
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel S. Greenspan, Yasutada Imamura
  • Mammalian pro-alpha3(V) collagen chain genes
    Publication number: 20030166842
    Abstract: Mammalian &agr;3(V) pro-collagen and collagen polypeptides and variants thereof are encoded by exemplified polynucleotides. Investigative, diagnostic and therapeutic methods employ the polypeptides, polynucleotides and related materials, such as antibodies, sense- or antisense oligonucleotides and polynucleotides, and the like.
    Type: Application
    Filed: February 26, 2001
    Publication date: September 4, 2003
    Inventors: Daniel S. Greenspan, Yasutada Imamura
  • Mammalian tolloid-like gene and protein
    Patent number: 6579702
    Abstract: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld and distinct from human or murine mTll-1 is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein having distinct activities. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: June 17, 2003
    Assignee: Wiconsin Alumni Research Foundation
    Inventors: Daniel S. Greenspan, Ian C. Scott, Christina L. Thomas
  • MAMMALIAN TOLLOID-LIKE GENE AND PROTEIN
    Publication number: 20020150946
    Abstract: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld and distinct from human or murine mTll-1 is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein having distinct activities. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
    Type: Application
    Filed: April 2, 1999
    Publication date: October 17, 2002
    Inventors: DANIEL S. GREENSPAN, IAN C. SCOTT, CHRISTINA L. THOMAS
  • Mammalian tolloid-like gene and protein
    Publication number: 20020048565
    Abstract: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
    Type: Application
    Filed: August 29, 2001
    Publication date: April 25, 2002
    Inventors: Daniel S. Greenspan, Kazuhiko Takahara, Guy G. Hoffman
  • Mammalian tolloid-like gene and protein
    Patent number: 6297011
    Abstract: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: October 2, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel S. Greenspan, Kazuhiko Takahara, Guy G. Hoffman
  • System for assaying modulators of procollagen maturation
    Patent number: 6037139
    Abstract: Potential modulators of a procollagen-cleaving enzyme are assessed by determining the ability of the enzyme to cleave procollagen in the presence and absence of a potential modulator in the culture medium of cells induced to secrete a procollagen-cleaving enzyme.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: March 14, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel S. Greenspan, Seungbok Lee
  • Mammalian tolloid-like gene and protein
    Patent number: 5981717
    Abstract: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: November 9, 1999
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel S. Greenspan, Kazuhiko Takahara, Guy G. Hoffman
  • Mammalian tolloid-like gene and protein
    Patent number: 5939321
    Abstract: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: August 17, 1999
    Assignee: Wisconsin Alumni Research Foundatiion
    Inventors: Daniel S. Greenspan, Kazuhiko Takahara, Guy G. Hoffman