Patents by Inventor Daniel S. Pearson

Daniel S. Pearson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A NOVEL ROLE FOR TERMINAL RNA URIDYLATION AND RNA TURNOVER IN ONCOGENESIS
    Publication number: 20190300885
    Abstract: Described herein is a LIN28-independent role of TUTases in oncogenesis. Provided herein are compositions and methods for treating cancer via inhibition of TUTases. TUTase depletion also sensitizes the cells to disruptions in RNA metabolism and/or protein metabolism. Thus, further provided herein are strategies of combination therapy, combining TUTase inhibitors, agents that disrupt RNA metabolism, and agents that disrupt protein metabolism, to treat cancer.
    Type: Application
    Filed: June 7, 2017
    Publication date: October 3, 2019
    Applicant: Children's Medical Center Corporation
    Inventors: George Q. Daley, Kaloyan Tsanov, Daniel S. Pearson