Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: Training ammunition that may be utilized by the U.S. Army, Marines and other Armed Forces that conduct training exercises with about 20 mm to 155 mm cartridges. The munition would electronically generate/initiated a signature that would become present at the target. The user would be able to observe the signature with the unaided eye during day or night training, or with devices such as night vision goggles/monocular or thermal sites. The generated signature would not utilize any explosives or pyrophoric iron powders, and would not create an increased fire hazard risk to the user. The munition would be able to survive typical rough handling and firing weapon malfunctions without becoming unusable, or causing delays in training exercises.

Abstract: Examples of active millimeter-wave imaging systems are described which may utilize modulation schemes to provide illumination signals. The use of modulation techniques may allow for the use of direct-conversion receivers while retaining an ability to separate desired received signal from self-jamming and/or DC offset signal(s) generated by the direct-conversion receivers. In some examples, modulation schemes include the use of balanced orthogonal codes which may support MIMO or massive MIMO imaging systems.

Abstract: A multi-disc brake (30,60) includes a piston housing (32,62) and attached torque tube (34,64) located about an axle (67,97). Axially adjacent the piston housing (32,62) is a brake actuator (40,70). In one embodiment, the piston housing (32) is located axially between an actuator member (59A) of the brake actuator (40) and a thrust sleeve (20) located about the axle sleeve (19) and abutting a wheel sleeve (16) engaging a wheel bearing assembly (12). In another embodiment, the actuator member (89A) can extend to engage a stationary portion (91) of the axle (97).

Abstract: A multi-disc brake (80) includes a piston housing (102) and attached torque tube (94) located about an axle (87). Integrated within the piston housing (102) is a brake actuator (90). The piston housing (102) is located axially between an actuator member (98) of the brake actuator (90) and an axle sleeve (109) and radial portion 87a of the axle (87). Hydraulic actuation of the brake actuator (90) displaces axially the actuator member (98) against a stationary thrust sleeve (99) such that the piston housing (102) is compressed between the actuator member (98) and axle sleeve (109), thereby reducing torsional vibrational movement of the piston housing (102) and torque tube (94) about the axle (87).

Abstract: A torque tube (50) having a cylindrical body (50a) is characterized by a plurality of key surfaces (50k) which extend radially from the surface (50s) and extend longitudinally from an inboard end (50i) to terminate at an outboard end (50o) in a radius (R3) which defines a transition (50t) into a radially extending rib (50r). The cylindrical body portion between adjacent keys (50k) also extends at the outboard end (50o) into a flange (50f) which is continuous about the outboard end of the tube. The combination of radially extending ribs (50r) and flange (50f) define T-sections at the outboard end (50o) which provide the strength requirements of the torque tube in its intended service application.