Abstract: An orthopedic surgical instrument or impactor arranged and configured to convert rotational motion of a motor into linear (e.g., reciprocating) motion of an internal hammer to drive an orthopedic implant (e.g., an acetabular cup, a femoral hip implant, an intramedullary nail, etc.) and/or a surgical tool (e.g., a broach, a rasp, a cutting tool, etc.) into a patient's bone. In addition, and/or alternatively, the orthopedic surgical instrument may be reversed to assist with removal of the orthopedical implant and/or surgical tool. In some examples, the orthopedic surgical instrument includes a swashplate and a wobble shaft to convert the rotational motion into linear motion. In addition, and/or alternatively, the orthopedic surgical instrument may be arranged and configured with multiple modes of operation to enable a user to selectively, and independently, adjust the impact energy, frequency, etc.

Abstract: A bowling shoe sole fastening system of structures that allows a variety of outsoles to be attached to and detached from the midsole that improve the consistency of the flex of the show throughout a bowler's stride, which allow the bowling shoe to be adjusted to achieve consistent stopping and sliding characteristics over a variety of bowling lane conditions and maintain consistent performance in the flex of the shoe across cycles of attachment, detachment, and reattachment.

Abstract: A mobile imaging system or mini C-arm with an increased range of motion is disclosed. The mini C-arm including a mobile base, a C-arm assembly, and an arm assembly for coupling the C-arm assembly and the mobile base. The arm assembly being coupled to the mobile base via a first joint assembly that enables the arm assembly to move relative to the mobile base about first and second axes of rotation. Thus, in use, the first joint assembly enables two degrees of motion—a first vertical pivoting or rotational movement and a second horizontal pivoting or rotational movement. The first joint assembly being coupled to the base via a horizontal axis of rotation that is located at a vertically fixed position so that the horizontal axis of rotation is positioned at a fixed height or distance from the base, and hence a fixed height or distance from the floor.

Abstract: A mobile imaging system or mini C-arm with an increased range of motion is disclosed. The mini C-arm including a mobile base, a C-arm assembly, and an arm assembly for coupling the C-arm assembly and the mobile base. The arm assembly being coupled to the mobile base via a first joint assembly that enables the arm assembly to move relative to the mobile base about first and second axes of rotation. Thus, in use, the first joint assembly enables two degrees of motion—a first vertical pivoting or rotational movement and a second horizontal pivoting or rotational movement. The first joint assembly being coupled to the base via a horizontal axis of rotation that is located at a vertically fixed position so that the horizontal axis of rotation is positioned at a fixed height or distance from the base, and hence a fixed height or distance from the floor.

Abstract: A medical imaging device includes an x-ray source disposed at a first end of an arm, and an x-ray detector disposed at a second end of the arm opposite of the x-ray source. At least one of the x-ray source, the x-ray detector, and a portion of the arm are selectively adjustable with respect to the arm.

Abstract: Provided herein are methods of monitoring for the production of select antibodies in a non-human animal, comprising (a) immunizing a non-human animal with an immunogen; (b) obtaining a blood sample comprising antibody secreting cells (ASCs) from said non-human animal; and (c) individually assaying ASCs present in the blood sample, or a fraction thereof, for the production of select antibodies. Methods of guiding antibody production in a non-human animal for the production of select antibodies are also provided. In exemplary embodiments, the method comprises performing a cycle of (a) to (c), as above, and repeating the cycle when the percentage of ASCs producing select antibodies is below a threshold. In various aspects, the cycle is repeated until the percentage of ASCs producing select antibodies is at or above a threshold. Single cell assays are further provided herein.

Abstract: A method of processing a substrate that includes: forming recesses in a first mask layer over a mask stack including a lower hardmask, a middle mask, and an upper hardmask, the recesses defining an initial pattern including a plurality of spacer structures, each of the spacer structures having a first sidewall and an opposite second sidewall, the first sidewall having a different height from the second sidewall; etching the upper hardmask, selectively to the middle mask, to transfer the initial pattern to the upper hardmask; etching the middle mask, selectively to the lower hardmask and the patterned upper hardmask, to transfer a pattern of the patterned upper hardmask to the middle mask; and etching the lower hardmask, selectively to the patterned middle mask, to transfer a pattern of the patterned middle mask to the lower hardmask.

Abstract: A vehicle includes a first storage assembly configured to be disposed within a seating row. A first base is disposed on seatbacks and a sidewall is rotatably coupled to the first base. A divider is disposed over the first base and configured to slidably engage the sidewall to define first and second storage spaces. A second storage assembly is configured to be disposed in a cargo area. The second storage assembly includes a second base disposed on a floor in the cargo area. A first frame member is coupled to the second base and defines a first rail. A second frame member is coupled to the second base and has a second rail. A door is coupled to the first frame member and the second frame member and configured to translate along the first and second rails between an opened position and a closed position.

Abstract: A medical imaging device includes an x-ray source disposed at a first end of an arm, and an x-ray detector disposed at a second end of the arm opposite of the x-ray source. At least one of the x-ray source, the x-ray detector, and a portion of the arm are selectively adjustable with respect to the arm.

Abstract: A mini C-arm with a movable X-ray source is disclosed. The mini C-arm including a moveable base, a C-arm assembly, and an arm assembly for coupling the C-arm assembly and the base. The C-arm assembly includes a first end, a second end, and a curved intermediate body portion defining an arc length. The source is positioned adjacent to the first end. A detector is positioned at the second end. The source is moveable along the arc length and relative to the detector to enable a plurality of images of the patient's anatomy to be acquired including a first image when the X-ray source is at a first position and a second image when the X-ray source is at a second position. The images being taken without moving the patient's anatomy. The C-arm assembly may include a motor and a belt drive system for moving the source relative to the detector.

Abstract: According to one aspect, the present description concerns a target (20) for the production of nuclear particles. The target comprises a shell (24) formed by a surface of revolution and mounted in rotation about an axis of rotation (21) that coincides with an axis of revolution of the shell.

Abstract: The present disclosure provides methods and compositions for precisely controlling the expression levels of mammalian genes using CRISPRi or CRISPRa and one or more modified sgRNAs. The methods and compositions are useful for, inter alia, titrating the expression of a gene of interest, identifying drug targets and mechanisms of drug resistance, and enabling the analysis of and control over metabolic and signaling pathway fluxes.

Abstract: A medical imaging device includes an x-ray source disposed at a first end of an arm, and an x-ray detector disposed at a second end of the arm opposite of the x-ray source. At least one of the x-ray source, the x-ray detector, and a portion of the arm are selectively adjustable with respect to the arm.

Abstract: A mobile imaging system or mini C-arm with an increased range of motion is disclosed. The mini C-arm including a mobile base, a C-arm assembly, and an arm assembly for coupling the C-arm assembly and the mobile base. The arm assembly being coupled to the mobile base via a first joint assembly that enables the arm assembly to move relative to the mobile base about first and second axes of rotation. Thus, in use, the first joint assembly enables two degrees of motion—a first vertical pivoting or rotational movement and a second horizontal pivoting or rotational movement. The first joint assembly being coupled to the base via a horizontal axis of rotation that is located at a vertically fixed position so that the horizontal axis of rotation is positioned at a fixed height or distance from the base, and hence a fixed height or distance from the floor.

Abstract: A device for measuring the energy of neutrons incident in a first direction is provided. The device comprises a gas between a cathode and an anode, the anode comprising a matrix array of electron detectors, the first direction being orthogonal to the anode-cathode direction.

Abstract: A medical imaging device includes an x-ray source disposed at a first end of an arm, and an x-ray detector disposed at a second end of the arm opposite of the x-ray source. At least one of the x-ray source, the x-ray detector, and a portion of the arm are selectively adjustable with respect to the arm.

Abstract: The invention relates to a footwear kit and method of providing a footwear kit comprising a forepart that can be removably attached to both a left shoe and a right shoe, in which the shoes are substantially asymmetric about a line running from the front to the back of the shoe, and in which the periphery of the forepart substantially matches the periphery of the toe region of both the left shoe and the right shoe.

Abstract: The invention relates to a footwear kit and method of providing a footwear kit comprising a forepart that can be removably attached to both a left shoe and a right shoe, in which the shoes are substantially asymmetric about a line running from the front to the back of the shoe, and in which the periphery of the forepart substantially matches the periphery of the toe region of both the left shoe and the right shoe.

Abstract: A device for measuring the energy of neutrons incident in a first direction is provided. The device comprises a gas between a cathode and an anode, the anode comprising a matrix array of electron detectors, the first direction being orthogonal to the anode-cathode direction.

Abstract: A medical imaging device includes an x-ray source disposed at a first end of an arm, and an x-ray detector disposed at a second end of the arm opposite of the x-ray source. At least one of the x-ray source, the x-ray detector, and a portion of the arm are selectively adjustable with respect to the arm.