Abstract: Provided herein are chimeric antigen receptors (CARs) that include a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein the spacer consists of 1, 2 or 3 C2-set Ig-like domain(s) e.g., C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. Also provided herein are compositions including a) an immune cell expressing a CAR, wherein the CAR is specific for a tag and b) a tagged polypeptide.

Abstract: The present invention provides a CAR comprising a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein said spacer consists of 1, 2 or 3 C2-set Ig-like domain(s). Said C2-set Ig-like domain(s) may be selected from the group of C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. A composition comprising a) an immune cell expressing said CAR, wherein said CAR is specific for a tag and b) a tagged polypeptide is also disclosed.

Abstract: Certain example embodiments relate to a system (1) for handling performance issues of a production Complex Event Processing, CEP, system (2) during runtime. The production CEP system (2) includes at least one event source, at least one continuous query and at least one event sink. The system (1) includes: at least one monitoring sensor for producing a stream of status events relating to the production CEP system (2); and a monitoring CEP system (10) for executing at least one continuous analysis query on the stream of status events to produce a stream of monitoring events. The stream of monitoring events indicates performance issues of the production CEP system (2) relating to the throughput, the latency, and/or the memory consumption of the production CEP system (2).

Abstract: The invention is directed to a heating block (100) for a continuous flow heater in which a water flow system with channels is arranged in the heating block (100). A heating path (300) of the water flow system forms a hottest channel (340) with a hottest heating element (341) during operation of the continuous flow heater. The hottest channel (340) is arranged downstream of at least one channel (310, 320, 330) of the heating path (300) in a flow direction (110). The hottest channel (340) of the heating path (300) is surrounded by at least four channels which are located between an outer surface (120) of the heating block (100) and the hottest channel (340). Accordingly, the hottest channel (340) of the continuous flow heater is surrounded by at least four channels and is shielded relative to an air space (160).

Abstract: Certain example embodiments relate to a system (1) for handling performance issues of a production Complex Event Processing, CEP, system (2) during runtime. The production CEP system (2) includes at least one event source, at least one continuous query and at least one event sink. The system (1) includes: at least one monitoring sensor for producing a stream of status events relating to the production CEP system (2); and a monitoring CEP system (10) for executing at least one continuous analysis query on the stream of status events to produce a stream of monitoring events. The stream of monitoring events indicates performance issues of the production CEP system (2) relating to the throughput, the latency, and/or the memory consumption of the production CEP system (2).

Abstract: A wound transformer core is provided with at least one core loop made of a magnetic material. The transformer core includes multiple thin amorphous band-like iron sheets which are concentrically stacked around at least one center axis. A lower yoke section, an upper yoke section, and at least two limb sections are formed. The transformer core includes a modular plate-like support structure which is affixed upright to the center axis on both face sides of the lower yoke section and on both face sides of each limb section such that neighbored iron sheets are affixed together at their outer edge. The modular plate-like support structure includes, for each face side of the corresponding core sections, at least two plate-like modules, which are each connected to each other by a first or second plug-in connection.

Abstract: A wound transformer core is provided with at least one core loop made of a magnetic material. The transformer core includes multiple thin amorphous band-like iron sheets which are concentrically stacked around at least one center axis. A lower yoke section, an upper yoke section, and at least two limb sections are formed. The transformer core includes a modular plate-like support structure which is affixed upright to the center axis on both face sides of the lower yoke section and on both face sides of each limb section such that neighbored iron sheets are affixed together at their outer edge. The modular plate-like support structure includes, for each face side of the corresponding core sections, at least two plate-like modules, which are each connected to each other by a first or second plug-in connection.

Abstract: The present invention relates to a dispersion at least comprising particles comprising at least one magnetic iron oxide as component A and a solvent mixture as component B comprising (B1) 5% to 95% by weight of at least one water-miscible organic solvent LM as component B1 and (B2) 5% to 95% by weight of water as component B2, the sum of components B1 and B2 making 100% by weight, and to a method for producing a dispersion of this kind, comprising at least the steps (I) mixing particles comprising at least one magnetic iron oxide with at least one water-miscible organic solvent LM and water, (II) homogenizing the mixture from step (I), where a shearing energy of at least 2 kW/m3 is introduced into the mixture in step (II).

Abstract: The invention relates to a block-protected braking system for a vehicle, comprising an electronic controller (22, 24) arranged in a housing (12), a valve block (14) to accommodate solenoid valves for controlling the hydraulic fluid in the braking system, and a pump motor (16) for a pump which delivers hydraulic fluid, with the solenoids (20) of the valves being accommodated in an intermediate body (18) which is arranged between the valve block (14) and the housing (12) of the electronic controller, said intermediate body (18) comprising electric connecting means (34, 38) for connecting the electronic controller with the solenoids (20), and said valve block (14) and said housing (12) of the electronic controller being connected with each other by means of the intermediate body (18).