Patents by Inventor Daniel Schindler

Daniel Schindler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220297372
    Abstract: Techniques for producing at least one PLA strip involve: a) providing a strip-shaped extruded PLA film, b) heating the PLA film provided according to step a) to a temperature in the range from 40 to 70° C., c) cutting the PLA film heated according to step b) into the at least one PLA strip, and d) stretching the PLA film cut according to step c).
    Type: Application
    Filed: July 22, 2020
    Publication date: September 22, 2022
    Inventors: Kenneth Schindler, Bert Woellner, Daniel Götze, Torsten Müller, Jens Weinhold
  • Publication number: 20220244348
    Abstract: An OFDM radar sensor including multiple transmission channels and at least one reception channel, and a method for operating such an OFDM radar sensor. At least for first transmission channels, the signal form of the signal to be transmitted, which includes a sequence of OFDM symbols in question, is progressively computed in portions for each transmission channel, and multiple buffer memories are used in alternation for storing a computed portion of the signal form and for reading out a previously computed and stored preceding portion of the signal form, which is converted from digital to analog and transmitted. A particular portion of the signal form is computed and stored in one of the buffer memories while a preceding portion of the signal form is being read out from another of the buffer memories and converted from digital to analog, and transmitted on the transmission channel in question.
    Type: Application
    Filed: June 4, 2020
    Publication date: August 4, 2022
    Inventors: Daniel Schindler, Robert Nabholz, Juergen Hasch
  • Publication number: 20220162673
    Abstract: Methods and devices relate to the isolation of nucleic acids of interest from within a population of nucleic acids such as libraries of nucleic acid sequences.
    Type: Application
    Filed: November 29, 2021
    Publication date: May 26, 2022
    Applicant: Gen9, Inc.
    Inventors: Li-Yun A. Kung, Daniel Schindler, Joseph Jacobson
  • Publication number: 20210405184
    Abstract: A method for operating a radar sensor in a motor vehicle, in which in a SAR measuring mode according to the principle of the synthetic aperture, objects, including stationary objects, are located with high angular resolution. The same radar sensor is operated in time-shifted manner or concurrently in the SAR measuring mode and in a Doppler measuring mode, the relative speeds of objects, including moving objects, being measured with a time resolution in the Doppler measuring mode that is greater than the time resolution in the SAR measuring mode.
    Type: Application
    Filed: April 13, 2021
    Publication date: December 30, 2021
    Inventors: Daniel Schindler, Gor Hakobyan, Johannes Fink, Kai Penske, Michael Schoor, Armin Himmelstoss
  • Publication number: 20210395724
    Abstract: Methods and apparatus of some aspects of the invention relate to the synthesis of high fidelity polynucleotides. In particular, aspects of the invention relate to concurrent enzymatic removal of amplification sequences and ligation of processed oligonucleotides into nucleic acid assemblies. According to some embodiments, the invention provides a method for producing a target nucleic acid having a predefined sequence. In some embodiments, the method comprises the step of providing a plurality of oligonucleotides, wherein each oligonucleotides comprises (i) an internal sequence identical to a different portion of a sequence of a target nucleic acid, (ii) a 5? sequence flanking the 5? end of the internal sequence and a 3? flanking sequence flanking the 3? end of the internal sequence, each of the flanking sequence comprising a primer recognition site for a primer pair and a restriction enzyme recognition site.
    Type: Application
    Filed: June 28, 2021
    Publication date: December 23, 2021
    Inventors: Michael E. Hudson, Li-Yun A. Kung, Daniel Schindler, Stephen Archer, Ishtiaq Saaem
  • Publication number: 20210380991
    Abstract: Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of cohesive-end double-stranded nucleic acid fragments each having two different and non-complementary overhangs; (3) ligating the plurality of cohesive-end double-stranded nucleic acid fragments with a ligase; and (4) forming a linear arrangement of the plurality of cohesive-end double-stranded nucleic acid fragments, wherein the unique arrangement comprises the target nucleic acid.
    Type: Application
    Filed: July 12, 2021
    Publication date: December 9, 2021
    Applicant: Gen9, Inc.
    Inventors: Joseph Jacobson, Daniel Schindler, Scott S. Lawton
  • Publication number: 20210382160
    Abstract: A method for operating an OFDM radar system. The method includes: generating an analog transmit signal in the baseband; mixing the analog transmit signal with a first mixed signal at a first frequency, the first frequency of the first mixed signal lying centrally between two sidebands of a transmission band; receiving a received signal; mixing the received signal with a second mixed signal at a second frequency into the baseband, the second frequency of the second mixed signal lying in a defined manner adjacent to a total bandwidth of the received signal.
    Type: Application
    Filed: December 7, 2019
    Publication date: December 9, 2021
    Inventors: Daniel Schindler, Juergen Hasch
  • Publication number: 20210380968
    Abstract: Aspects of the invention relate to methods, compositions for designing and producing a target nucleic acid. In particular, aspects of the invention relate to the multiplex synthesis of target polynucleotides.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 9, 2021
    Applicant: Gen9, Inc.
    Inventors: Joseph Jacobson, Daniel Schindler, Ishtiaq Saaem, Scott S. Lawton, Martin J. Goldberg, Michael E. Hudson, Li-Yun A. Kung
  • Publication number: 20210339219
    Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.
    Type: Application
    Filed: July 16, 2021
    Publication date: November 4, 2021
    Applicant: Gen9, Inc.
    Inventors: Joseph Jacobson, Li-Yun A. Kung, Andrew Kirk Wilson, Senthil Ramu, Daniel Schindler, Michael E. Hudson
  • Patent number: 11130948
    Abstract: Aspects of the invention relate to methods, compositions for designing and producing a target nucleic acid. In particular, aspects of the invention relate to the multiplex synthesis of target polynucleotides.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: September 28, 2021
    Assignee: Gen9, Inc.
    Inventors: Joseph Jacobson, Daniel Schindler, Ishtiaq E. Saaem, Scott S. Lawton, Martin J. Goldberg, Michael E. Hudson, Li-yun A. Kung
  • Patent number: 11084014
    Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: August 10, 2021
    Assignee: Gen9, Inc.
    Inventors: Joseph Jacobson, Li-yun A. Kung, Andrew Kirk Wilson, Senthil Ramu, Daniel Schindler, Michael Hudson
  • Patent number: 11072789
    Abstract: Methods and apparatus of some aspects of the invention relate to the synthesis of high fidelity polynucleotides. In particular, aspects of the invention relate to concurrent enzymatic removal of amplification sequences and ligation of processed oligonucleotides into nucleic acid assemblies. According to some embodiments, the invention provides a method for producing a target nucleic acid having a predefined sequence. In some embodiments, the method comprises the step of providing a plurality of oligonucleotides, wherein each oligonucleotides comprises (i) an internal sequence identical to a different portion of a sequence of a target nucleic acid, (ii) a 5? sequence flanking the 5? end of the internal sequence and a 3? flanking sequence flanking the 3? end of the internal sequence, each of the flanking sequence comprising a primer recognition site for a primer pair and a restriction enzyme recognition site.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: July 27, 2021
    Assignee: Gen9, Inc.
    Inventors: Michael E. Hudson, Li-Yun A. Kung, Daniel Schindler, Stephen Archer, Ishtiaq Saaem
  • Publication number: 20210139888
    Abstract: Methods and compositions relate to the sorting and cloning of high fidelity nucleic acids using high throughput sequencing. Specifically, nucleic acid molecules having the desired predetermined sequence can be sorted from a pool comprising a plurality of nucleic acids having correct and incorrect sequences.
    Type: Application
    Filed: January 19, 2021
    Publication date: May 13, 2021
    Applicant: Gen9, Inc.
    Inventors: Joseph Jacobson, Martin J. Goldberg, Li-Yun A. Kung, Daniel Schindler, Michael E. Hudson
  • Patent number: 10927369
    Abstract: Methods and compositions relate to the sorting and cloning of high fidelity nucleic acids using high throughput sequencing. Specifically, nucleic acid molecules having the desired predetermined sequence can be sorted from a pool comprising a plurality of nucleic acids having correct and incorrect sequences.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: February 23, 2021
    Assignee: Gen9, Inc.
    Inventors: Joseph Jacobson, Martin J. Goldberg, Li-Yun A. Kung, Daniel Schindler, Michael E. Hudson
  • Publication number: 20210040477
    Abstract: Aspects of the invention relate to methods for designing and producing non-random libraries of nucleic acids. In particular, aspects of the invention relate to synthesis of non-random libraries by multiplexed polynucleotides synthesis.
    Type: Application
    Filed: October 28, 2020
    Publication date: February 11, 2021
    Applicant: Gen9, Inc.
    Inventors: Joseph Jacobson, Daniel Schindler, Ishtiaq Saaem, Nicholas James Guido
  • Publication number: 20200255518
    Abstract: The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 13, 2020
    Applicants: LFB USA, Inc., Genzyme Corporation
    Inventors: Daniel Schindler, Harry M. Meade, Timothy Edmunds, John McPherson
  • Publication number: 20200208139
    Abstract: Methods and apparatus of some aspects of the invention relate to the synthesis of high fidelity polynucleotides. In particular, aspects of the invention relate to concurrent enzymatic removal of amplification sequences and ligation of processed oligonucleotides into nucleic acid assemblies. According to some embodiments, the invention provides a method for producing a target nucleic acid having a predefined sequence. In some embodiments, the method comprises the step of providing a plurality of oligonucleotides, wherein each oligonucleotides comprises (i) an internal sequence identical to a different portion of a sequence of a target nucleic acid, (ii) a 5? sequence flanking the 5? end of the internal sequence and a 3? flanking sequence flanking the 3? end of the internal sequence, each of the flanking sequence comprising a primer recognition site for a primer pair and a restriction enzyme recognition site.
    Type: Application
    Filed: December 13, 2019
    Publication date: July 2, 2020
    Applicant: Gen9, Inc.
    Inventors: Michael E. Hudson, Li-Yun A. Kung, Daniel Schindler, Stephen Archer, Ishtiaq Saaem
  • Publication number: 20200197896
    Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.
    Type: Application
    Filed: August 7, 2019
    Publication date: June 25, 2020
    Applicant: Gen9, Inc.
    Inventors: Joseph Jacobson, Li-yun A. Kung, Andrew Kirk Wilson, Senthil Ramu, Daniel Schindler, Michael Hudson
  • Publication number: 20200189023
    Abstract: A method for producing an overlap composite material from sheet metal is described, wherein a first sheet (1) of a first metal and a second sheet (2) of a second metal, which has a lower strength than the first metal, are positioned one above another in an overlapping manner in an edge region, and are then joined by rolling. In accordance with the invention, provision is made for the first sheet (1) to have a wedge-shaped edge in cross-section, and for the second sheet (2) to be positioned with its edge on a side surface (3) of the first sheet (1) formed by the wedge-shaped edge, wherein the side surface (3) formed by the wedge-shaped edge of the first sheet (1) has a greater width than the side surface (4) of the edge of the second sheet (2) positioned on the said side surface (3) of the first sheet (1), and, after positioning, the sheets (1, 2) are joined by rolling.
    Type: Application
    Filed: February 24, 2020
    Publication date: June 18, 2020
    Inventors: Ralph Mädler, Daniel Schindler, Le Huu Bao, Michael Schuckhardt
  • Publication number: 20190323077
    Abstract: Methods of obtaining sequence information about target polynucleotide having a predefined sequence are disclosed. The methods include sequencing by ligation and sequencing by polymerase.
    Type: Application
    Filed: February 5, 2019
    Publication date: October 24, 2019
    Inventors: Joseph Jacobson, Daniel Schindler