Patents by Inventor DANIEL SCHUMPERLI

DANIEL SCHUMPERLI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclo-DNA antisense oligonucleotides, compositions, and methods for the treatment of disease
    Patent number: 10465191
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 5, 2019
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, SORBONNE UNIVERSITE, UNIVERSITAT BERN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Daniel Schumperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit
  • TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
    Publication number: 20170260524
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Application
    Filed: February 9, 2017
    Publication date: September 14, 2017
    Inventors: Daniel SCHUMPERLI, Christian LEUMANN, Denis FURLING, Luis GARCIA, Thomas VOIT
  • TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
    Publication number: 20120149756
    Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
    Type: Application
    Filed: April 9, 2010
    Publication date: June 14, 2012
    Applicants: Associatin Institut de Myologie, Centre National De La Recherche Scientifique, Universitât Bern, Universite Pierre et Marie Curie
    Inventors: Daniel Schümperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit
  • Stable alteration on pre-mRNA splicing patterns by modified RNAs
    Publication number: 20030114411
    Abstract: The present invention provides a method of upregulating expression of a protein of interest (e.g., a native protein) in a cell, the cell containing a DNA encoding the protein, which DNA contains a mutation that causes downregulation of the protein by aberrant splicing in a pre-mRNA, wherein the DNA encodes the pre-mRNA; wherein the pre-mRNA contains a native intron having a first set of splice elements, which native intron is removed by splicing when the mutation is absent to produce a first mRNA encoding the protein; and wherein the pre-mRNA further contains an aberrant intron different from the native intron having a second set of splice elements, which aberrant intron is removed by splicing when the mutation is present to produce an aberrant second mRNA different from the first mRNA.
    Type: Application
    Filed: November 27, 2002
    Publication date: June 19, 2003
    Inventors: Ryszard Kole, Daniel Schumperli, Halina Sierakowska, Daniel Suter
  • STABLE ALTERATION OF PRE-MRNA SPLICING PATTERNS BY MODIFIED RNAS
    Publication number: 20030036519
    Abstract: The present invention provides a method of upregulating expression of a protein of interest (e.g., a native protein) in a cell, the cell containing a DNA encoding the protein, which DNA contains a mutation that causes downregulation of the protein by aberrant splicing in a pre-mRNA, wherein the DNA encodes the pre-mRNA; wherein the pre-mRNA contains a native intron having a first set of splice elements, which native intron is removed by splicing when the mutation is absent to produce a first mRNA encoding the protein; and wherein the pre-mRNA further contains an aberrant intron different from the native intron having a second set of splice elements, which aberrant intron is removed by splicing when the mutation is present to produce an aberrant second mRNA different from the first mRNA.
    Type: Application
    Filed: April 20, 1999
    Publication date: February 20, 2003
    Inventors: RYSZARD KOLE, DANIEL SCHUMPERLI, HALINA SIERAKOOWSKA, DANIEL SUTER