Abstract: An activation mechanism for an on-body medicament delivery device, wherein the activation mechanism comprises: an activation button structure configured to be moved between an initial position and an activation position, an activation pin sleeve, and a biased activation pin received by the activation pin sleeve, the activation pin being configured to be linearly movable from an initial retracted position relative to the activation pin sleeve to an extended position towards which the activation pin is biased, the activation button structure being configured to interact with the activation pin sleeve in the initial position to cause the activation pin sleeve to engage with and maintain the activation pin in the retracted position, and wherein the activation button structure is configured to interact with the activation pin sleeve when the activation button structure is moved linearly towards the activation position causing the activation pin sleeve to release the activation pin from the retracted position.

Abstract: A settlement monitoring system 1 for a construction site 400, the system 1 comprising an elongate liquid vessel 100, a continuous body of liquid 110 within the vessel 100, a first sensor 201 housed within a first portion of the vessel, and at least one additional sensor 202-206 housed within a second portion of the liquid vessel 100, wherein the sensors 201-206 are submerged within the liquid 110 and each sensor 201-206 is capable of detecting a pressure of the liquid 110, wherein in use the first portion of the liquid vessel 100 is configured to be situated at a known reference point of the site 400, the second portion is configured to be embedded within the ground 416, and the pressures are communicated to a surface system 308, the surface system 308 being configured to record the pressures.

Abstract: A clamp having a first arcuate clamp member pivotally connected to a second arcuate clamp member via a first pivot member 16 located at one end of the clamp members, the clamp members being pivotable between an open configuration in which the free ends of the clamp members are displaced from one another facilitating the insertion of the mating pipe flanges to be clamped, and a closed configuration wherein the free ends of the clamp members contact one another and encircle the mating flanged end connections. Associated with the first arcuate clamp member is an arcuate articulated lever which itself is pivotally attached by a third pivot member linking to member, which is itself pivotally attached by second pivot member to the free end of the first clamp member.

Abstract: The present disclosure provides a sub-assembly for a medicament delivery device, the sub-assembly extending along a longitudinal axis in a longitudinal direction from a proximal end to a distal end. The sub-assembly comprises a housing, and a plunger rod arranged at least partly inside the housing, the plunger rod being rotationally locked relative to the housing. The plunger rod comprises a flexible arm, the flexible arm comprising a first surface facing towards the proximal end. A component of the sub-assembly other than the plunger rod comprises a second surface facing towards the distal end, with the first surface and the second surface being arranged so that, when the plunger rod moves towards the proximal end relative to the component during medicament delivery device use, the first surface and the second surface engage to flex the flexible arm in a circumferential direction relative to the component and then disengage so that the flexible arm flexes back relative to the component.

Abstract: The present disclosure provides a sub-assembly for a medicament delivery device, the sub-assembly extending along a longitudinal axis in a longitudinal direction from a proximal end to a distal end. The sub-assembly comprises a housing and a plunger rod. The plunger rod is arranged at least partly inside the housing. The plunger rod comprises a first surface facing towards the proximal end and a component of the sub-assembly other than the plunger rod comprises a second surface facing towards the distal end, with the first surface and the second surface being arranged so that, when the plunger rod moves towards the proximal end relative to the component during medicament delivery device use, the first surface and the second surface engage to rotate the plunger rod relative to the component and then disengage so that the plunger rod rotates back relative to the component. The sub-assembly comprises a torsion spring attached at one end to the plunger rod and at the other end to the component.

Abstract: A clamp having a first arcuate clamp member pivotally connected to a second arcuate clamp member via a first pivot member 16 located at one end of the clamp members, the clamp members being pivotable between an open configuration in which the free ends of the clamp members are displaced from one another facilitating the insertion of the mating pipe flanges to be clamped, and a closed configuration wherein the free ends of the clamp members contact one another and encircle the mating flanged end connections. Associated with the first arcuate clamp member is an arcuate articulated lever which itself is pivotally attached by a third pivot member linking to member, which is itself pivotally attached by second pivot member to the free end of the first clamp member.

Abstract: The present disclosure generally relates to medicament delivery devices such as autoinjectors, and particularly concerns cover structures configured to surround a medicament delivery member at a proximal end of the medicament delivery device.

Abstract: An apparatus for securely joining ropes for rope suspension or payload tie down. The apparatus includes a two substantially identical channel assemblies configured having a first bend to form a rope groove on one end and a second bend to form a cam channel on the other end, the cam channel having a rivet hole and a pin therethrough to enable a cam to rotate therein, and an attachment mechanism to secure the channel assemblies back-to-back thereto. By opening the cam of either assembly, a rope may be threaded through the rope grove, then again on the opposite assembly. The rope can be pulled from its end away from the assemblies to tighten prior to closing the cam(s) upon the ropes. The rope can further be secured by continuing to pull after the cam has been closed, or by using an optional tightening mechanism and method.

Abstract: The present disclosure generally relates to medicament delivery devices such as autoinjectors, and particularly concerns pads for attaching medicament delivery devices such as autoinjectors to an injection site.

Abstract: An apparatus for securely joining ropes for rope suspension or payload tie down. The apparatus includes a two substantially identical channel assemblies configured having a first bend to form a rope groove on one end and a second bend to form a cam channel on the other end, the cam channel having a rivet hole and a pin therethrough to enable a cam to rotate therein, and an attachment mechanism to secure the channel assemblies back-to-back thereto. By opening the cam of either assembly, a rope may be threaded through the rope grove, then again on the opposite assembly. The rope can be pulled from its end away from the assemblies to tighten prior to closing the cam(s) upon the ropes. The rope can further be secured by continuing to pull after the cam has been closed, or by using an optional tightening mechanism and method.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

Abstract: A plunger rod for a medicament delivery device, the plunger rod comprising: a tubular body extending along a longitudinal axis between a closed end and an open end; and a whistle orifice on a tubular wall of the tubular body; the whistle orifice is positioned between the open end of the tubular body and the closed end of the tubular body.

Abstract: A clamp having a first arcuate clamp member pivotally connected to a second arcuate clamp member via a first pivot member 16 located at one end of the clamp members, the clamp members being pivotable between an open configuration in which the free ends of the clamp members are displaced from one another facilitating the insertion of the mating pipe flanges to be clamped, and a closed configuration wherein the free ends of the clamp members contact one another and encircle the mating flanged end connections. Associated with the first arcuate clamp member is an arcuate articulated lever which itself is pivotally attached by a third pivot member linking to member, which is itself pivotally attached by second pivot member to the free end of the first clamp member.