Patents by Inventor Daniel Shanafelt

Daniel Shanafelt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PRODUCING COLLAGENASE
    Publication number: 20260234593
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Application
    Filed: April 20, 2026
    Publication date: August 13, 2026
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • Process intermediate in the purification of collagenase drug substances
    Patent number: 12644108
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Grant
    Filed: February 15, 2023
    Date of Patent: June 2, 2026
    Assignee: Endo Operations Limited
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • METHOD OF PURIFYING AND ISOLATING COLLAGENASE
    Publication number: 20260085304
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Application
    Filed: September 23, 2025
    Publication date: March 26, 2026
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • Method of purifying and isolating collagenase
    Patent number: 12448615
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: October 21, 2025
    Assignee: Endo Operations Limited
    Inventors: Christine A Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • METHOD OF PRODUCING COLLAGENASE
    Publication number: 20240110171
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Application
    Filed: February 15, 2023
    Publication date: April 4, 2024
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • Method of producing collagenase
    Patent number: 11473074
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 18, 2022
    Assignee: Endo Global Aesthetics Limited
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • METHOD OF PRODUCING COLLAGENASE
    Publication number: 20220119791
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 21, 2022
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • METHOD OF PRODUCING COLLAGENASE
    Publication number: 20180327731
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Application
    Filed: March 28, 2018
    Publication date: November 15, 2018
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt