Patents by Inventor Daniel Shao-Chen Liu

Daniel Shao-Chen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for protein labeling using lipoic acid ligases
    Patent number: 9284541
    Abstract: The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: March 15, 2016
    Assignees: Massachusetts Institute of Technology, University of Washington through its Center for Commercialization
    Inventors: Alice Y. Ting, David Baker, Florian Richter, Lucas Nivon, Daniel Shao-Chen Liu
  • PROBE INCORPORATION MEDIATED BY ENZYMES
    Publication number: 20150125904
    Abstract: Compositions (e.g., lipoic acid ligase polypeptides and lipoic acid analogs) and uses thereof in the Probe Incorporation Mediated By Enzymes (PRIME) methods both in vitro and in vivo. Also described herein are kits for performing the PRIME method and vectors/kits for expressing the lipoic acid ligases.
    Type: Application
    Filed: March 13, 2013
    Publication date: May 7, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Alice Y. Ting, Daniel Shao-Chen Liu
  • METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES
    Publication number: 20120129159
    Abstract: The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.
    Type: Application
    Filed: October 6, 2011
    Publication date: May 24, 2012
    Inventors: Alice Y. Ting, David Baker, Florian Richter, Lucas Nivon, Daniel Shao-Chen Liu