Abstract: Systems and methods for molecular residual disease (MRD) status determination for a subject's cancer condition subject uses sequence reads from methylation sequencing of cell-free DNA fragments from the subject's liquid biopsy sample to determine their methylation patterns. From this, corresponding numbers of circulating-tumor DNA (ctDNA) fragments mapping to each of a plurality of regions of the genome of the subject's species are determined. Corresponding expected numbers of noise fragments in each region are determined based on corresponding distributions using observed sequencing depths and learned background emission rates for each region. An excess fragments per million (FPM) value, corrected by an observed CHG methylation level, is determined from the observed number of ctDNA fragments in excess of the expected number of noise fragments in each region. MRD is called when the CHG corrected excess FPM value satisfies a threshold value, and a call against MRD is made when it does not.

Abstract: A digital transmit beamformer for an ultrasound system has a waveform sample memory which stores sequences of samples of different pulse transmit waveforms of differing pulse widths. The memory is shared by a plurality of transmit channels, each of which can access its own selected sample sequence, independent of the selections by other channels. Waveform sample readout by the channels occurs substantially simultaneously during a transmit event, producing a transmit beam from a transmit aperture with different pulse waveforms applied to different elements of the transmit aperture. Higher energy waveforms with wider pulse widths are applied to central elements of the aperture and lower energy waveforms with narrower pulse widths are applied to lateral elements of the aperture to produce an apodized transmit beam.

Abstract: Embodiments of the present disclosure provide for generating improved, feasible, and optimized pathways for optimizing operation of an industrial plant or component thereof. Embodiments utilize a multi-variate optimization model that may utilize real-time data and any number of available dynamic and static configurations to optimize for multiple optimization parameters. The multi-variate optimization model outputs an optimization pathway, for example including any number of transformation action(s) representing decarbonization step(s), that enable configuration of the plant or processing unit(s) thereof in a manner that optimizes operations of the plant or processing unit(s).

Abstract: A digital transmit beamformer for an ultrasound system has a waveform sample memory which stores sequences of samples of different pulse transmit waveforms of differing pulse widths. The memory is shared by a plurality of transmit channels, each of which can access its own selected sample sequence, independent of the selections by other channels. Waveform sample readout by the channels occurs substantially simultaneously during a transmit event, producing a transmit beam from a transmit aperture with different pulse waveforms applied to different elements of the transmit aperture. Higher energy waveforms with wider pulse widths are applied to central elements of the aperture and lower energy waveforms with narrower pulse widths are applied to lateral elements of the aperture to produce an apodized transmit beam.

Abstract: The semiconductor device includes: a gate electrode on a semiconductor substrate via a gate insulating film; an offset drain layer in the semiconductor substrate on one side of the gate electrode; a drain layer on the offset drain layer; and a source layer in the semiconductor substrate on another side of the gate electrode. The semiconductor device further includes: a protective film covering the semiconductor substrate; a field plate on the protective film, and having a portion above the offset drain layer; and a field plug connected to the field plate and in the protective film and above the offset drain layer, in such a manner as to avoid reaching the offset drain layer.

Abstract: A LDMOS transistor that may include (i) a first region that is a reduced surface field (RESURF) implant region of a first type; (ii) a second region that is a RESURF implant region of a second type, wherein the first type differs from the second type; (iii) a gate; (iv) a stepped oxide region and a gate oxide region that are positioned above the first region and below the gate.

Abstract: A LDMOS transistor that may include (i) a first region that is a reduced surface field (RESURF) implant region of a first type; (ii) a second region that is a RESURF implant region of a second type, wherein the first type differs from the second type; (iii) a gate; (iv) a stepped oxide region and a gate oxide region that are positioned above the first region and below the gate.

Abstract: The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.

Abstract: The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

Abstract: The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

Abstract: The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

Abstract: The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.

Abstract: The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.

Abstract: The present invention is directed to methods and means for making and using Angpt13 polypeptides. The invention specifically concerns the use of Angpt13 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angpt13 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.

Abstract: A braking system for a lift truck performs all service braking using truck traction drive motors. Mechanical, spring applied, electrically released brakes are coupled to wheels on opposite sides of the truck with the mechanical brakes applying unequal braking forces to the wheels. The mechanical brakes perform park braking and, in the event an electrical system problem arises, backup braking as well that can be modulated by an operator of the truck regardless of the operating condition of the truck.

Abstract: A system for treatment of one or more flowing materials includes a support bed (32) comprising a plurality of support elements (34). The support bed may have a void fraction of at least 45%. An active bed (36), such as a bed of catalytic elements, may be supported by the support bed. The void fraction of the support bed may be larger than that of an equivalent bed of conventional, spherical elements, enabling significant improvements in the flow rate of reactants through the bed and/or a reduced pressure drop across the support bed.

Abstract: A system for treatment of one or more flowing materials includes a support bed (32) comprising a plurality of support elements (34). The support bed may have a void fraction of at least 45%. An active bed (36), such as a bed of catalytic elements, may be supported by the support bed. The void fraction of the support bed may be larger than that of an equivalent bed of conventional, spherical elements, enabling significant improvements in the flow rate of reactants through the bed and/or a reduced pressure drop across the support bed.

Abstract: The present invention is directed toward an apparatus for the in-situ preparation of macromolecules via uniform glow discharge plasma, and a method for using the apparatus. The method and apparatus are designed for preparing macromolecules from biological materials, including at least DNA, RNA, saccharides, lipids and proteins, in a manner which eliminates the need for biological solvents or chemicals, grinders, freezing, or detergents. The present invention is capable of operating at one atmosphere of pressure. The present method is a non-destructive, thus rendering the yielded macromolecules amenable for further modification or analysis via exposure to the glow discharge plasma sustained at substantially atmospheric pressure in air or modified gas environments. The device includes a spaced apart pair of metallic electrodes. At least one of the electrodes is covered with a high dielectric insulation material. A power supply is provided for energizing the electrodes.

Abstract: This invention relates to the control of flying insects in and around homes, commercial establishments, farm buildings and the like. Specifically, the formulation, design and technique involved in the device allows the user to maintain an insect free environment and to dispense an insecticide capable of eliminating flying insects in a safe and effective manner. The use of a translucent shield that contains an insecticide that leeches to the surface through the heat of ambient light, while converting ambient light into a spectrum that attracts flying insects provides an economical method of delivering a killing agent to the insect.