Patents by Inventor Daniel Shoemaker

Daniel Shoemaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10727804
    Abstract: An integrated circuit is a layered device, on a semiconductor substrate, which contains metal electrodes that sandwich a piezoelectric layer, followed by a magnetostrictive layer and a metal coil. The metal electrodes define an electrical port across which to receive an alternating current (AC) voltage, which is applied across the piezoelectric layer to cause a time-varying strain in the piezoelectric layer. The magnetostrictive layer is to translate the time-varying strain, received by way of a vibration mode from interaction with the piezoelectric layer, into a time-varying electromagnetic field. The metal coil, disposed on the magnetostrictive layer, includes a magnetic port at which to induce a current based on exposure to the time-varying electromagnetic field generated by the magnetostrictive layer.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: July 28, 2020
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Songbin Gong, Ruochen Lu, Tomas Manzaneque Garcia, Cheng Tu, Daniel Shoemaker, Chengxi Zhao
  • Publication number: 20200179451
    Abstract: Compounds that either produce a higher proportion or greater absolute number of phenotypically identified naive, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies, such as those providing improvements in one or more therapeutic outcomes, are provided.
    Type: Application
    Filed: July 19, 2018
    Publication date: June 11, 2020
    Inventors: Jonathan Rosen, Eigen Peralta, Ian Hardy, Betsy D. Rezner, Christian Maine, Daniel Shoemaker, David Robbins, Lucas Thompson
  • Publication number: 20200102536
    Abstract: Compositions and methods for manufacturing induced immune regulatory cells comprising induced myeloid suppressive cells including MDSCs (myeloid-derived suppressor cells), dendritic cells, macrophages, and subpopulations thereof are provided. Also provided are methods and compositions for further modifying and modulating the induced immune regulatory cells to achieve enhanced therapeutic potential in treating autoimmune disorders, hematological malignancies, solid tumors, viral infections, neurodegenerative disorders, inflammatory conditions, or GvHD.
    Type: Application
    Filed: June 13, 2018
    Publication date: April 2, 2020
    Inventors: Philippe A. Parone, Robert S. Tacke, Bahram Valamehr, Daniel Shoemaker, Martin Hosking, Lisa Guerrettaz
  • Patent number: 10591391
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 17, 2020
    Assignees: Verinata Health, Inc., The General Hospital Corporation, GPB Scientific, LLC
    Inventors: Roland Stoughton, Ravi Kapur, Barb Ariel Cohen, Daniel Shoemaker, Ronald W. Davis, Mehmet Toner
  • Publication number: 20190111085
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • Patent number: 10172888
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 8, 2019
    Assignee: Fate Therapeutics, Inc.
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • Patent number: 10155984
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: December 18, 2018
    Assignees: The General Hospital Corporation, GPB Scientific, LLC, Verinata Health, Inc.
    Inventors: Daniel Shoemaker, Mehmet Toner, Ravi Kapur, Roland B. Stoughton, Ronald W. Davis
  • Publication number: 20180115294
    Abstract: An integrated circuit is a layered device, on a semiconductor substrate, which contains metal electrodes that sandwich a piezoelectric layer, followed by a magnetostrictive layer and a metal coil. The metal electrodes define an electrical port across which to receive an alternating current (AC) voltage, which is applied across the piezoelectric layer to cause a time-varying strain in the piezoelectric layer. The magnetostrictive layer is to translate the time-varying strain, received by way of a vibration mode from interaction with the piezoelectric layer, into a time-varying electromagnetic field. The metal coil, disposed on the magnetostrictive layer, includes a magnetic port at which to induce a current based on exposure to the time-varying electromagnetic field generated by the magnetostrictive layer.
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Inventors: Songbin Gong, Rouchen Lu, Tomas Manzaneque Garcia, Cheng Tu, Daniel Shoemaker, Chengxi Zhao
  • Publication number: 20170049820
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: September 2, 2016
    Publication date: February 23, 2017
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • Patent number: 9474430
    Abstract: A fixed full coverage wash system that includes a base portion having a generally square or rectangular shaped outer portion that extends into one or more corners of a tub of a dishwasher. The base portion is operably connected to the plurality of arms for the delivery of a pressurized liquid. The base portion may include a plurality of tube segments that are not in fluid communication with at least a portion of the other tube segments. Such an arrangement may be used in connection with a rotor that controls the release, or timing, of pressurized liquid through sprayers in the tube segments. According to certain embodiments, the movement and/or position of the rotor may be controllable, such as, for example, through the use of a controller and motor that allows for the control of the location and/or concentration of where the pressurized liquid is sprayed.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 25, 2016
    Assignee: SEARS BRANDS, L.L.C.
    Inventors: Anthony Daniel Shoemaker, Thomas DeSalvo, Christopher Salatino
  • Patent number: 9347100
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 24, 2016
    Assignees: GPB Scientific, LLC, The General Hospital Corporation, Verinata Health, Inc.
    Inventors: Daniel Shoemaker, Ravi Kapur, Mehmet Toner, Roland Stoughton, Ronald W. Davis
  • Patent number: 9273355
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 1, 2016
    Assignees: The General Hospital Corporation, GPB Scientific, LLC, Verinata Health, Inc.
    Inventors: Daniel Shoemaker, Ravi Kapur, Mehmet Toner, Roland B. Stoughton, Ronald W. Davis
  • Publication number: 20150232936
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Application
    Filed: April 27, 2015
    Publication date: August 20, 2015
    Inventors: Daniel Shoemaker, Mehmet Toner, Ravi Kapur, Roland B. Stoughton, Ronald W. Davis
  • Patent number: 9017942
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 28, 2015
    Assignees: The General Hospital Corporation, GPB Scientific, LLC, Verinata Health, Inc.
    Inventors: Daniel Shoemaker, Ravi Kapur, Mehmet Toner, Roland Stoughton, Ronald W. Davis
  • Publication number: 20150064139
    Abstract: The invention provides cell potency assays for measuring, determining, identifying, confirming, or validating the therapeutic potential of a cell population. Cell potency assays may be performed with various types of cells, including stem or progenitor cells, such as, for example, hematopoietic stem or progenitor cells. Cell potency assays may also be performed on stem or progenitor cells that have been treated with one or more agents to enhance therapeutic potential. Hematopoietic cells having therapeutic potential are useful in downstream clinical applications for increasing engraftment, reconstitution, homing, and proliferation in vivo.
    Type: Application
    Filed: March 11, 2014
    Publication date: March 5, 2015
    Applicant: FATE THERAPEUTICS, INC.
    Inventors: Daniel SHOEMAKER, David L. ROBBINS
  • Publication number: 20140261584
    Abstract: A fixed full coverage wash system that includes a base portion having a generally square or rectangular shaped outer portion that extends into one or more corners of a tub of a dishwasher. The base portion is operably connected to the plurality of arms for the delivery of a pressurized liquid. The base portion may include a plurality of tube segments that are not in fluid communication with at least a portion of the other tube segments. Such an arrangement may be used in connection with a rotor that controls the release, or timing, of pressurized liquid through sprayers in the tube segments. According to certain embodiments, the movement and/or position of the rotor may be controllable, such as, for example, through the use of a controller and motor that allows for the control of the location and/or concentration of where the pressurized liquid is sprayed.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Anthony Daniel Shoemaker, Thomas DeSalvo, Christopher Salatino
  • Publication number: 20140030232
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: August 12, 2011
    Publication date: January 30, 2014
    Applicant: FATE THERAPEUTICS, INC.
    Inventors: Daniel Shoemaker, Pratik Multani, Caroline Desponts, David L. Robbins, Paul Grayson, John Mendlein
  • Publication number: 20130295565
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 7, 2013
    Inventors: DANIEL SHOEMAKER, Ravi Kapur, Mehmet Toner, Roland B. Stoughton, Ronald W. Davis
  • Publication number: 20130288242
    Abstract: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
    Type: Application
    Filed: January 10, 2013
    Publication date: October 31, 2013
    Inventors: Roland Stoughton, Ravi Kapur, Mehmet Toner, Daniel Shoemaker, Ronald W. Davis
  • Publication number: 20130288354
    Abstract: Provided are improved vessels for cell culture, cell storage, treatment of cells, and cell therapy. The improved vessels comprise one or more devices temperature indicating devices, elapsed time indicating devices and/or devices that indicate environmental conditions of the vessel contents, such as pH, oxygen and carbon dioxide concentration, and glucose concentration.
    Type: Application
    Filed: June 27, 2013
    Publication date: October 31, 2013
    Inventors: Pratik MULTANI, Paul GRAYSON, Daniel SHOEMAKER