Abstract: The disclosure relates to a method for the diagnosis of Alzheimer's disease (AD) in a patient, wherein the expression profile of miRNAs is determined in a blood sample and a comparison of the expression levels of defined miRNAs with a reference sample is carried out. The disclosure also relates to the use of the defined miRNAs as markers for the diagnosis of Alzheimer's disease and to a kit for the diagnosis of Alzheimer's disease.

Abstract: A microscreen, substantially formed of a photoresist material, is produced by applying a photoresist layer to a support using a liquid photoresist, partially covering the photoresist layer with a mask that defines the structure of the microscreen, exposing the photoresist to radiation, developing the photoresist, and removing the photoresist from the support.

Abstract: A method produces a microscreen by providing a support and applying a photoresist layer with a definable thickness to the support. The photoresist is exposed by radiation using a mask that defines the structure of the microscreen. The photoresist is then developed. The thickness of the photoresist layer is selected such that, in a sub-region of the photoresist layer, the radiation used for the exposure penetrates only so slightly that practically no cross-linking of the photoresist takes place.

Abstract: A method for producing a microscreen is described in which, in a first step, a support is provided, in a second step, a photoresist layer with a definable thickness is applied to the support, in an exposure step, the photoresist is exposed by means of the effect of radiation using a mask that defines the structure of the microscreen, in a development step, the photoresist is developed, characterized in that the thickness of the photoresist layer is selected such that, in a sub-region of the photoresist layer, the radiation used for the exposure penetrates only so slightly that practically no cross-linking of the photoresist takes place.

Abstract: A microscreen, substantially formed of a photoresist material, is produced by applying a photoresist layer to a support using a liquid photoresist, partially covering the photoresist layer with a mask that defines the structure of the microscreen, exposing the photoresist to radiation, developing the photoresist, and removing the photoresist from the support.

Abstract: An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a center-to-center in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.

Abstract: An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.

Abstract: A device for detecting a substance of a fluid or the concentration of a substance of a fluid may include a carrier to which a resonator is applied, to which a chemically sensitive material for adsorption of a substance to be detected is applied. The adsorption of the substance increases the mass of the resonator. The concentration of the substance in the liquid can be determined by measuring the frequency change of the resonator.

Abstract: An intervention device is disclosed for collecting biological material comprises a surface with a coating covering the surface at least in part. In at least one embodiment, capture molecules, by which the biological material can be bound, are immobilized on the coating. The capture molecules are distributed stochastically on the coating.

Abstract: A device is disclosed for filtering a particle to be detected from a fluid. In at least one embodiment, the device includes a substrate and, applied above it, a protective layer, a channel being disposed between them for the purpose of receiving a fluid containing different particles. In at least one embodiment, the channel extends at least partially in a spiral shape between its inlet and outlet and on its internal wall contains a coating for attracting a particle type to be filtered, which coating is applied at least on the radially outside subsection of the internal wall of the channel. Owing to the laminar longitudinal movement of the fluid inside the channel a radially outward directed centrifugal force acts on the particles, with the result that per time unit more particles come into contact with the radially outside subsection of the internal wall of the channel than the radially inside subsection of the internal wall of the channel. The filter effect is reinforced as a result.

Abstract: An apparatus is disclosed for acquiring, detecting, and, optionally, analyzing cells in a biological liquid, which apparatus has a microfluidic system. In at least one embodiment, the apparatus includes at least one microfluidic channel having a small cross-section which is completely or partially coated with cell-specific binding molecules and which has no flow obstacles dividing the fluid flow; at least one apparatus for generating a steady and alterable liquid flow through the microfluidic channel, and optionally at least one apparatus for analyzing the genetic information of the cell.

Abstract: A device to extract material of a material reservoir has at least one guide tube with internal space and with an inner wall surrounding the internal space; at least one sled that can implement a sled translation movement in the inner space along a longitudinal alignment of the guide tube; and at least one collection unit with collection surface to collect the material. The collection unit and the sled are coupled to one another such that the sled translation movement of the sled leads to a collection translation movement of the collection surface of the collection unit, and such that the collection surface can be inserted into the material reservoir and be withdrawn from the material reservoir. A rotation mechanism that is operated manually or automatically can be provided with which a wire, which acts as a collection device, can be displaced in vivo over a length of 1 mm to up to 2 cm within a venous cannula.

Abstract: In a chromatograph, a separation column is disposed between an injection system and a detector. The separation column includes a bundle of capillaries which are formed of carbon nanotubes with a typical diameter of 0.5 nm to 5 nm and may number in the several hundreds.

Abstract: A nanostructure is provided on a substrate by forming at least one multi-electrode arrangement on the substrate, wherein said electrodes comprise respective electrode areas projected with respect to the opposite electrode ends which extend along a line in such a way that the adjacent ends produce a respectively frequency time-variable potential difference. A suspension of nano-object such as nanotubes, nanowires and/or carbon nanotubes is produced and then transferred to the substrate between the adjacent ends. The assembly of respective individual nano-objects is dielectrophoreticly deposited on the line between said adjacent ends, and the assembly of respective nano-objects is fused in the area of the ends in such a way that the nanostructure is formed.