Patents by Inventor Daniel Simard

Daniel Simard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV protease inhibitors
    Patent number: 9737545
    Abstract: The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: August 22, 2017
    Assignees: Merck Sharp & Dohme Corp., Merck Canada Inc.
    Inventors: John A. McCauley, Christian Beaulieu, David Jonathan Bennett, Christopher J. Bungard, Sheldon Crane, Thomas J. Greshock, Katharine M. Holloway, Helen Juteau, Daniel McKay, Carmela Molinaro, Oscar Miguel Moradei, Christian Nadeau, Daniel Simard, Satyanarayana Tummanapalli, Vouy Linh Truong, Karine M. Villeneuve, Peter D. Williams
  • HIV PROTEASE INHIBITORS
    Publication number: 20160296527
    Abstract: The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
    Type: Application
    Filed: December 17, 2014
    Publication date: October 13, 2016
    Applicants: MERCK SHARP & DOHME CORP., MERCK CANADA INC.
    Inventors: John A. McCauley, Christian Beaulieu, David Jonathan Bennett, Christopher J. Bungard, Sheldon Crane, Thomas J. Greshock, Katharine M. Holloway, Helen Juteau, Daniel McKay, Carmela Molinaro, Oscar Miguel Moradei, Christian Nadeau, Daniel Simard, Satyanarayana Tummanapalli, Vouy Linh Truong, Karine M. Villeneuve, Peter D. Williams
  • Azaindole derivatives as CRTH2 receptor antagonists
    Patent number: 8546422
    Abstract: Compounds of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: October 1, 2013
    Assignee: Merck Canada Inc.
    Inventors: Yves Leblanc, Carl Berthelette, Daniel Simard, Mohamed Helmi Zaghdane
  • RENIN INHIBITORS
    Publication number: 20120035214
    Abstract: The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal insufficiency.
    Type: Application
    Filed: April 1, 2010
    Publication date: February 9, 2012
    Applicants: Merck Canada Inc., Merck Sharp & Dohme Corp.
    Inventors: Daniel J. McKay, Melissa Arbour, Renee Aspiotis, Austin Chen, Pierre-Andre Fournier, Michel Gallant, Yongxin Han, Helene Juteau, Patrick Lacombe, Sebastien Laliberte, Sophie Lauzon, Carmela Molinaro, Paul O'Shea, Yeeman Ramtohul, Daniel Simard, Dwight MacDonald, Bruce Mackay, Christophe Mellon, Krista Morley, Chit Tsui, Sarah Jennifer Dolman, Greg Hughes, Jacob Janey
  • AZAINDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
    Publication number: 20110178115
    Abstract: Compounds of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 21, 2011
    Applicant: Merck Frosst Canada Ltd
    Inventors: Yves Leblanc, Carl Berthelette, Daniel Simard, Mohamed Helmi Zaghdane
  • Pyridin-2-one compounds useful as inhibitors of thrombin
    Publication number: 20070161643
    Abstract: There is provided a compound of formula I wherein the dashed line, R1, R2, R3a, R3b, A, D, E, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).
    Type: Application
    Filed: February 2, 2005
    Publication date: July 12, 2007
    Inventors: Malken Bayrakdarian, Kristina Berggren, Ojvind Davidsson, Ola Fjellstrom, David Gustafsson, Stephen Hanessian, Tord Inghardt, Ingemar Nilsson, Mats Nagard, Daniel Simard, Eric Therrien
  • Apparatus and method for metal strip casting
    Patent number: 7059384
    Abstract: Disclosed is a method and apparatus for continuously casting a metal strip. A casting pool of molten metal is formed, and a metal strip is solidified onto a casting surface. The temperature of the casting surface is maintained above a predetermined critical value. By maintaining the surface temperature above the predetermined critical value, either the heat transfer uniformity or the heat transfer capacity or both are improved.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: June 13, 2006
    Assignee: National Research Council of Canada
    Inventors: Dominique Bouchard, Jean-Paul Nadeau, Francois Hamel, Daniel Simard, Serge F. Turcotte
  • Apparatus and method for metal strip casting
    Publication number: 20030015309
    Abstract: Disclosed is a method and apparatus for continuously casting a metal strip. A casting pool of molten metal is formed, and a metal strip is solidified onto a casting surface. The temperature of the casting surface is maintained above a predetermined critical value. By maintaining the surface temperature above the predetermined critical value, either the heat transfer uniformity or the heat transfer capacity or both are improved.
    Type: Application
    Filed: June 14, 2002
    Publication date: January 23, 2003
    Inventors: Dominique Bouchard, Jean-Paul Nadeau, Francois Hamel, Daniel Simard, Serge F. Turcotte