Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: A method and an apparatus are provided that may be applicable to refrigeration assets, including refrigeration plants and cold-storage facilities comprising large numbers of refrigeration assets. The performance of refrigerators and refrigeration devices may be monitored based on temperature and electrical current and other measurements known or deemed to be correlated with refrigeration performance. Refrigeration assets in need of repair may be identified and a repair process may be specified, classified, managed and optimized. The immediate effectiveness and long-term persistence of repairs may be determined over time. The refrigeration assets may be classified according to reliability, performance, make, model and manufacturer. The effectiveness of repairs may be classified based on measured performance results following repairs.

Abstract: A method and an apparatus are provided that may be applicable to refrigeration assets, including refrigeration plants and cold-storage facilities comprising large numbers of refrigeration assets. The performance of refrigerators and refrigeration devices may be monitored based on temperature and electrical current and other measurements known or deemed to be correlated with refrigeration performance. Refrigeration assets in need of repair may be identified and a repair process may be specified, classified, managed and optimized. The immediate effectiveness and long-term persistence of repairs may be determined over time. The refrigeration assets may be classified according to reliability, performance, make, model and manufacturer. The effectiveness of repairs may be classified based on measured performance results following repairs.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: A portable mirror therapy device comprises a stiff divider panel attached to a base unit which supports the divider panel in an upright position to define two adjacent limb receiving spaces at opposite sides of the divider panel. A mirror is mounted on one face of the divider panel. A clamp, indicated generally by the reference numeral mounted at a lower end of the divider panel cooperates with an underside of the base unit for securing the base unit on a support such as a table or worktop. An exercise apparatus is mounted on the device and includes a limb engaging member, which in this case comprises a handle at a mirror side of the divider panel. The exercise apparatus is a resistance load training system and comprises a load cord extending from the handle to an associated resistance element mounted within a housing on an opposite side of the divider panel to the mirror.

Abstract: Embodiments of the present disclosure relate to a wrench for loosening or tightening a threaded joint of two drill-string components. The wrench is mountable on a drill assembly. The wrench comprises: a jaw assembly with opposing jaws for engaging the drill-string component therebetween; a first actuator for actuating the pair of opposing jaws between an engaged position and a disengaged position; a second actuator configured to pivot the jaw assembly and configured for applying a torque when engaged with the drill-string component; a third actuator configured to extend and retract the jaw assembly in a first plane substantially perpendicular to the longitudinal axis of the drill assembly when the wrench is mounted on the drill assembly; and a fourth actuator for actuating the wrench in a second plane substantially perpendicular to the first plane. Embodiments of the present disclosure also relate to drilling systems comprising the wrench.

Abstract: A rotatable nacelle includes an engine inlet configured to receive air and an inlet air management system (IAMS). The IAMS includes a primary inlet configured to selectively allow air to flow into a duct associated with the engine air inlet via the primary inlet and a secondary inlet configured to selectively allow air to flow into the duct associated with the engine air inlet via the secondary inlet. The secondary inlet is configured to receive an air filter.

Abstract: Embodiments of the present disclosure relate to a wrench for loosening or tightening a threaded joint of two drill-string components. The wrench is mountable on a drill assembly. The wrench comprises: a jaw assembly with opposing jaws for engaging the drill-string component therebetween; a first actuator for actuating the pair of opposing jaws between an engaged position and a disengaged position; a second actuator configured to pivot the jaw assembly and configured for applying a torque when engaged with the drill-string component; a third actuator configured to extend and retract the jaw assembly in a first plane substantially perpendicular to the longitudinal axis of the drill assembly when the wrench is mounted on the drill assembly; and a fourth actuator for actuating the wrench in a second plane substantially perpendicular to the first plane. Embodiments of the present disclosure also relate to drilling systems comprising the wrench.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: A gun part with integral spare extractor has a planar element having a first periphery and form adapted to provide a first gun part function, the planar element including an integral and detachable removable element having a periphery adapted to provide a second gun part function, and at least a portion of the periphery of the removable element being defined by an elongated articulated opening defined in the planar element such that the removable element is connected only by a limited portion that is breakable without affecting the utility of the planar element and the removable element. The removable element may be positioned away from the first periphery such that an enclosed aperture is defined by the opening upon removal of the removable element. The opening may be an articulated cut of consistent width. The removable part may be connected to the planar element by only a single span.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: A method and an apparatus are provided that may be applicable to refrigeration assets, including refrigeration plants and cold-storage facilities comprising large numbers of refrigeration assets. The performance of refrigerators and refrigeration devices may be monitored based on temperature and electrical current and other measurements known or deemed to be correlated with refrigeration performance. Refrigeration assets in need of repair may be identified and a repair process may be specified, classified, managed and optimized. The immediate effectiveness and long-term persistence of repairs may be determined over time. The refrigeration assets may be classified according to reliability, performance, make, model and manufacturer. The effectiveness of repairs may be classified based on measured performance results following repairs.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: A method and an apparatus are provided that may be applicable to refrigeration assets, including refrigeration plants and cold-storage facilities comprising large numbers of refrigeration assets. The performance of refrigerators and refrigeration devices may be monitored based on temperature and electrical current and other measurements known or deemed to be correlated with refrigeration performance. Refrigeration assets in need of repair may be identified and a repair process may be specified, classified, managed and optimized. The immediate effectiveness and long-term persistence of repairs may be determined over time. The refrigeration assets may be classified according to reliability, performance, make, model and manufacturer. The effectiveness of repairs may be classified based on measured performance results following repairs.

Abstract: A mechanical plate shifter system for moving filter plates in a filter press during a process of plate separation for filter cake removal comprises: a pusher to automatically engage with a single filter plate at the end of a stack or at the edge of a gap in the stack for moving the plate forward and then automatically disengaging when the plate reaches an end plate/dummy plate or another filter plate previously pushed. The filter plates are configured with handles for engaging with the pusher. The pusher is attached to a continuous drive belt and is configured with a pivoting structure including: a head with a receiving notch for a handle of a filter plate; and a counterweight for the head. The pusher and belt are configured relative to the filter plate stack to allow for filter plates to be engaged/disengaged by the receiving notch.

Abstract: The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

Abstract: The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.

Abstract: The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports.