Abstract: The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the ?-mating factor (?MF) of Saccharomyces cerevisiae and a non-?MF signal peptide.

Abstract: A computer-implemented method for participating in a blockchain-based data record distribution process which includes multiple input addresses for input nodes and multiple output addresses for output nodes. One or more input nodes of the group of input nodes perform steps of: collaborating to determine a stealth address, forming a first transaction that pools data records to be transferred to the stealth address, and transmitting the first transaction to be validated and incorporated into the blockchain. One or more output nodes of the group of output nodes perform steps of: searching the blockchain to find the first transaction, identifying the stealth address, forming a second transaction that distributes pooled data records, collaborating via a threshold signature scheme to sign the second transaction, and transmitting the second transaction to be validated and incorporated into the blockchain. The invention may be used in conjunction with any blockchain implementation.

Abstract: The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: An enclosable and stackable container comprising a tray and lid is provided with structural elements to permit rapid covering and uncovering of the tray, efficient stacking of containers, and safe transportation. At least one catching mechanism may be engaged quickly to securely cover the tray and its food contents and disengaged quickly to uncover the tray and its food contents, improving food hygiene practices. Foldable flange flaps enhance stacking strength to permit safe transportation of stacked containers and their food contents.

Abstract: The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

Abstract: In various embodiments, a medical device includes: a tissue sample-receiving surface; an electrode array that includes a first electrode and a second electrode that are positioned to contact a tissue sample disposed on the tissue sample-receiving surface; and an impedance bridge that is communicatively coupled to the electrode array.

Abstract: An implementation of the present application provides a computer-implemented method to increase the security of a blockchain-implemented transaction, the transaction including participation from a plurality of participating nodes, each participating node participating as a message originator, selector, and propagator. The method, implemented at a participating node, includes: receiving ciphertext from a prior node and determining whether the participating node is a selector node for said ciphertext received from the prior node. When the participating node is the selector node for said ciphertext, the method includes selecting a subset of said ciphertext, decrypting the selected subset of said ciphertext to provide opted ciphertext and transmitting said opted ciphertext to the next node. When the participating node is other than the selector node for said ciphertext, the method includes decrypting said ciphertext received from the prior node and transmitting the decrypted ciphertext to the next node.

Abstract: A noise management system analyzes messages from a sender to a plurality of recipients. The noise management system prepares a message frequency of a quantity of messages sent to a unique recipient over a period of time. The noise management system sends the message frequency with a noise rank to the client device for the recipient to review.

Abstract: A compliance monitoring module for an inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being configured to be pneumatically coupled to a flow channel of said inhaler through which a user can inhale; a processor configured to: receive data from a sensing element of the pressure sensor; receive data from a mode sensor configured to detect when the inhaler changes from an inactive mode to an active mode; and based on said data from said pressure sensor sensing element and said data from said mode sensor, compile a compliance report; and a transmitter configured to issue said compliance report.

Abstract: A wearable computing device includes a housing having a wrist-side face configured to sit against a wrist of a user of the wearable computing device when being worn by the user, an electronic display arranged within the housing, a plurality of biometric sensor electrodes positioned on the wrist-side face so as to maintain skin contact with the user when being worn on the wrist by the user, and at least one driver communicatively coupled to the plurality of biometric sensor electrodes. Each of the plurality of biometric sensor electrodes continuously measures, at least, one or more parameters indicative of electrical impedance of the user at a location of the skin contact.

Abstract: An ultrasonic injection device and methods of use are presented. The ultrasonic injection device comprises a housing, an injection nozzle attached to the housing, an ultrasonic vibration generator attached to the housing, and a pressure applicator. The injection nozzle has a number of openings configured to dispense a fluid. The ultrasonic vibration generator is configured to apply ultrasonic energy to fluid within the injection nozzle. The pressure application is configured to propel the fluid towards and out of the number of openings.

Abstract: An air handling unit (AHU) for a heating, ventilation, air conditioning, and refrigeration (HVACR) system includes a housing and a combustion heater disposed within the housing. The housing includes a combustion section with a first channel and a second channel. The combustion heater includes heat exchanger tubes and a tube support that supports heat exchanger tubes within the combustion section. The tube support slidably disposed in the first channel and the second channel. The combustion heater configured to be slidably removable from the AHU. An AHU for an HVACR system includes a housing with a fan section and a fan assembly disposed within the housing. The fan assembly including a pair of grooves slidably disposed on a pair of rails of the housing. The fan assembly configured to be both slidably removable from the AHU and liftably removable from the AHU.

Abstract: A system is provided for performing transaction mixing between a plurality of users on a blockchain. The system is configured to carry out the steps of: selecting an initiator node to calculate a deterministic hash function using a chosen random number; distribute the deterministic hash function to a plurality of users on the blockchain; choose an amount of time each user is given to construct a payment channel, retrieve the random number, and submit an execution transaction to a blockchain network; choose a second time for when a payment to a user is submitted to the blockchain network; and establish a one-way payment channel between every pair of users in an ordered set of the plurality of users to establish a transaction chain linking all users.

Abstract: A line launcher includes a launcher body extending along a longitudinal axis between a rear end and a front end. The line launcher further includes a handle, a trigger, and a removable battery. The line launcher further includes a compressed gas charge assembly. The line launcher further includes an elongated barrel coupled to the body at the front end. The line launcher further includes a throwline assembly, the throwline assembly including a projectile and a throwline, the projectile insertable into and ejectable from the elongated barrel.

Abstract: A noise management system analyzes messages from a sender to a plurality of recipients. The noise management system prepares a message frequency of a quantity of messages sent to a unique recipient over a period of time. The noise management system sends the message frequency with a noise rank to the client device for the recipient to review.

Abstract: A noise management system analyzes messages from a sender to a plurality of recipients. The noise management system prepares a message frequency of a quantity of messages sent to a unique recipient over a period of time. The noise management system sends the message frequency with a noise rank to the client device for the recipient to review.

Abstract: Rotary assist apparatus for recirculating ball steering gears are disclosed. An example motor vehicle steering system includes an input shaft to couple to a steering shaft of a motor vehicle, a worm gear, a first end of the worm gear coupled to the input shaft, a second end of the worm gear fixed to a helical spur gear, a ball nut surrounding a portion of the worm gear, the ball nut including ball bearings and ball guides, an intermediate gear fixed to a first pinion, the first pinion engaged with the helical spur gear, a motor fixed to a second pinion, the second pinion engaged with the intermediate gear, the motor to rotate the worm gear to translate the ball nut, and a sector gear engaged with the ball nut, the sector gear to rotate as the ball nut translates.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.