Patents by Inventor Daniel Strimling

Daniel Strimling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of cloning nucleic acids or producing proteins in a low endotoxin organism
    Patent number: 11746321
    Abstract: The invention provides engineered Vibrio sp. organisms that comprise a genetic modification to either or both of the lpxL and/or lpxM genes. The organisms score substantially lower in an in vitro endotoxin assay versus the unmodified or wild type organism. The organisms preserve substantially the growth rate of the corresponding unmodified organisms. The organisms can also have an exogenous nucleic acid cloned in the organism, or an exogenous nucleic acid encoding a protein, polypeptide, or peptide expressed by the organism, and optionally secreted from the organism.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: September 5, 2023
    Assignee: Telesis Bio Inc.
    Inventors: Matthew T Weinstock, Daniel G. Gibson, Daniel Strimling
  • VIBRIO SP. ORGANISMS WITH MODIFIED LIPOPOLYSACCHARIDE
    Publication number: 20210284954
    Abstract: The invention provides engineered Vibrio sp. organisms that comprise a genetic modification to either or both of the lpxL and/or lpxM genes. The organisms score substantially lower in an in vitro endotoxin assay versus the unmodified or wild type organism. The organisms preserve substantially the growth rate of the corresponding unmodified organisms. The organisms can also have an exogenous nucleic acid cloned in the organism, or an exogenous nucleic acid encoding a protein, polypeptide, or peptide expressed by the organism, and optionally secreted from the organism.
    Type: Application
    Filed: March 25, 2021
    Publication date: September 16, 2021
    Inventors: Matthew T Weinstock, Daniel G. Gibson, Daniel Strimling
  • Recombinant Vibrio natriegens organisms having a modified outer membrane
    Patent number: 10968496
    Abstract: The invention provides engineered Vibrio sp. organisms that comprise a genetic modification to either or both of the lpxL and/or lpxM genes. The organisms score substantially lower in an in vitro endotoxin assay versus the unmodified or wild type organism. The organisms preserve substantially the growth rate of the corresponding unmodified organisms. The organisms can also have an exogenous nucleic acid cloned in the organism, or an exogenous nucleic acid encoding a protein, polypeptide, or peptide expressed by the organism, and optionally secreted from the organism.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: April 6, 2021
    Assignee: Codex DNA, Inc.
    Inventors: Matthew T Weinstock, Daniel G. Gibson, Daniel Strimling
  • VIBRIO SP. ORGANISMS WITH MODIFIED LIPOPOLYSACCHARIDE
    Publication number: 20190153554
    Abstract: The invention provides engineered Vibrio sp. organisms that comprise a genetic modification to either or both of the lpxL and/or lpxM genes. The organisms score substantially lower in an in vitro endotoxin assay versus the unmodified or wild type organism. The organisms preserve substantially the growth rate of the corresponding unmodified organisms. The organisms can also have an exogenous nucleic acid cloned in the organism, or an exogenous nucleic acid encoding a protein, polypeptide, or peptide expressed by the organism, and optionally secreted from the organism.
    Type: Application
    Filed: October 8, 2018
    Publication date: May 23, 2019
    Inventors: Matthew T Weinstock, Daniel G. Gibson, Daniel Strimling