Patents by Inventor Daniel Summerer

Daniel Summerer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250054092
    Abstract: In accordance with an aspect of the present disclosure, a tissue imaging system includes a cassette configured to retain a tissue for imaging. The cassette includes a first cassette portion and a second cassette portion. The first cassette portion includes a recess formed in a central portion thereof, a window formed within the recess, and a first connection mechanism affixed thereto. The second cassette portion includes a cavity configured to compress a tissue therein and a second connection mechanism affixed thereto. An imaging device is configured to image the tissue through the window. Aligning the first connection mechanism and the second connection mechanism causes the first cassette portion to couple to the second cassette portion, compressing the tissue into the cavity for imaging.
    Type: Application
    Filed: October 30, 2024
    Publication date: February 13, 2025
    Inventor: Daniel Summer Gareau
  • Publication number: 20240361212
    Abstract: A system for tissue staining includes an upper housing, a lower housing, and a microscope lens. The upper housing includes a first reservoir configured to retain a solution therein, a valve attached to the reservoir including a turning knob, a first conduit configured to transport the solution, and a funnel fluidly connected to the first conduit. The lower housing is threadedly couped to the upper housing. The lower housing includes a top cassette portion having a window, a bottom cassette portion having a recess configured to retain a tissue therein, and a gasket disposed along an outer perimeter of the bottom cassette portion. The upper portion and the lower housing are coupled via threading. The microscope lens is configured to image the tissue through the window.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 31, 2024
    Inventors: Daniel Summer Gareau, Cassidy Sheehan, Chloe Lewandowski, Axel Batlle, Isabell Devereaux, Samuel Harrington
  • Patent number: 11391936
    Abstract: A confocal microscope is provided that includes one or more lasers focused by an optical system into a line on the surface of a sample mounted to a stage. The microscope further includes, at least one linear array detector that is optically conjugated to the focused line. The stage permits movement of the sample with respect to all other components of the microscope, which remain stationary.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: July 19, 2022
    Assignee: SURGIVANCE INC.
    Inventor: Daniel Summer Gareau
  • Patent number: 11286882
    Abstract: An exhaust casing for a gas turbine engine comprises a shroud configured to surround an exhaust cone, and a heat shield attached to the shroud. The heat shield has a first end and a second end axially spaced apart from each other. A gap is defined radially between the shroud and the heat shield. The gap is configured to enclose at least a portion of an interface defined between at least one strut and the shroud. The exhaust casing is configured to surround the exhaust cone and configured to be connected to the exhaust cone via the at least one strut.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 29, 2022
    Assignee: PRATT & WHITNEY CANADA CORP.
    Inventors: Assaf Farah, Marc Tardif, Daniel Summers-Lepine
  • Publication number: 20210187069
    Abstract: The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegenerative or neurological disease or disorder, pharmaceutical compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 24, 2021
    Applicant: Washington University
    Inventors: Aaron DiAntonio, Jeffrey D. Milbrandt, Daniel Summers, Stefanie Geisler, Xianrong Mao
  • Patent number: 10801441
    Abstract: A gas turbine engine comprises a main gas path having an inner flow boundary wall and an outer flow boundary wall. A turbine exhaust case inner body defines a portion of the inner flow boundary wall of the main gas path. A lobed exhaust mixer defines a portion of the outer flow boundary wall of the main gas path. A stiffener ring is interconnected to at least a number lobes of the lobed exhaust mixer by a plurality of circumferentially spaced-apart struts extending through the main gas path. The stiffener ring is attached to the turbine exhaust case inner body by flexible features, such as circumferentially spaced-apart spring blades.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: October 13, 2020
    Assignee: PRATT & WHITNEY CANADA CORP.
    Inventors: Daniel Summers-Lepine, Philippe Boyer, Assaf Farah, Daniel Coutu
  • Publication number: 20200081238
    Abstract: A confocal microscope is provided that includes one or more lasers focused by an optical system into a line on the surface of a sample mounted to a stage. The microscope further includes, at least one linear array detector that is optically conjugated to the focused line. The stage permits movement of the sample with respect to all other components of the microscope, which remain stationary.
    Type: Application
    Filed: October 24, 2019
    Publication date: March 12, 2020
    Inventor: Daniel Summer GAREAU
  • Patent number: 10466460
    Abstract: A confocal microscope is provided that includes one or more lasers focused by an optical system into a line on the surface of a sample mounted to a stage. The microscope further includes at least one linear array detector that is optically conjugated to the focused line. The stage permits movement of the sample with respect to all other components of the microscope, which remain stationary.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: November 5, 2019
    Assignee: SURGIVANCE INC.
    Inventor: Daniel Summer Gareau
  • Patent number: 9879315
    Abstract: Methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) an unmodified cytosine residue of interest, the methods making use of the capability of transcription-activator-like effector (TALE) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of TALE proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) the unmodified cytosine residue of interest.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: January 30, 2018
    Assignee: Universität Konstanz
    Inventors: Daniel Summerer, M. Grzegorz Kubik, Moritz Johannes Schmidt
  • Publication number: 20170242230
    Abstract: A confocal microscope is provided that includes one or more lasers focused by an optical system into a line on the surface of a sample mounted to a stage. The microscope further includes at least one linear array detector that is optically conjugated to the focused line. The stage permits movement of the sample with respect to all other components of the microscope, which remain stationary.
    Type: Application
    Filed: August 13, 2015
    Publication date: August 24, 2017
    Inventor: Daniel Summer Gareau
  • Publication number: 20160138094
    Abstract: The present invention relates to methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest o,r (ii) said unmodified cytosine residue of interest, said methods making use of the capability of transcription-activator-like effector (TALE) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of TALE proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest or (ii) said unmodified cytosine residue of interest.
    Type: Application
    Filed: June 26, 2014
    Publication date: May 19, 2016
    Inventors: Daniel Summerer, M. Grzegorz Kubik, Moritz Johnannes Schmidt
  • Patent number: 9102932
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: August 11, 2015
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lital Alfonta, Johnathan R. Chittuluru, Alexander Deiters, Dan Groff, Daniel Summerer, Meng-Lin Tsao, Jiangyun Wang, Ning Wu, Jianming Xie, Huaqiang Zeng, Mohammad Seyedsayamdost, James Turner
  • Patent number: 8759061
    Abstract: The present invention relates to DNA polymerases with a special mutation which have an enhanced mismatch discrimination, the preparation and use thereof. The thermostable DNA polymerases with this mutation are particularly suitable for diagnostic and molecular-biological methods, e.g., allele-specific PCR.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: June 24, 2014
    Assignee: Rheinische Friedrich-Wilhelms-Universitaet Bonn
    Inventors: Andreas Marx, Daniel Summerer, Nicolas Zackes Rudinger
  • Publication number: 20130244245
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
    Type: Application
    Filed: June 8, 2012
    Publication date: September 19, 2013
    Applicant: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lital Alfonta, Johnathan R. Chittuluru, Alexander Deiters, Dan Groff, Daniel Summerer, Meng-Lin Tsao, Jiangyun Wang, Ning Wu, Jianming Xie, Huaqiang Zeng, Mohammad Seyedsayamdost, James Turner
  • Publication number: 20120045771
    Abstract: The invention relates to a method for isolation of target molecules from a nucleic acid population.
    Type: Application
    Filed: December 11, 2009
    Publication date: February 23, 2012
    Applicant: FEBIT HOLDING GMBH
    Inventors: Markus Beier, Peer F. Staehler, Cord F. Staehler, Daniel Summerer, Jack T. Leonard, Stephan Bau, Anthony Caruso, Nadine Schracke, Andreas Keller, Helmut Hanenberg, Olaf Eckermann
  • Patent number: 8066264
    Abstract: The valve cover has a pair of tabs at the ends that are inserted into end sections of an orifice in the tray deck. The tabs of the valve cover abut against the underside of the tray deck while a pair of sloped portions of the valve cover rest on the top side of the tray deck in order to hold the valve cover in place.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: November 29, 2011
    Assignee: Sulzer Chemtech AG
    Inventors: Bartele Griepsma, Mark W. Pilling, Raymond Plüss, Daniel Summers
  • Publication number: 20110092380
    Abstract: The invention relates to improved molecular-biological processing equipment and an improved method of processing biological samples. The invention combines the provision of biologically functional molecules such as nucleic acids and peptides and of derivatives or analogs of these two classes of molecules in miniaturized flow cells with the sequential addition of reagents or fluids and serves for the processing of biological samples, such as proteins, nucleic acids, biogenic small molecules such as e.g. metabolites, viruses or cells, which for this purpose are introduced into the miniaturized flow cells.
    Type: Application
    Filed: December 31, 2007
    Publication date: April 21, 2011
    Applicant: FEBIT HOLDING GMBH
    Inventors: Peer Stahler, Markus Beier, Cord Stahler, Daniel Summerer, Mark Matzas, Sonja Vorwerk
  • Publication number: 20100256012
    Abstract: The invention relates to an extraction method for isolating target molecules from a sample with the help of a molecule library.
    Type: Application
    Filed: November 24, 2008
    Publication date: October 7, 2010
    Applicant: FEBIT HOLDING GMBH
    Inventors: Markus Beier, Stephan Bau, Daniel Summerer, Mark Matzas, Peer F. Staehler
  • Publication number: 20090134533
    Abstract: The valve cover has a pair of tabs at the ends that are inserted into end sections of an orifice in the tray deck. The tabs of the valve cover abut against the underside of the tray deck while a pair of sloped portions of the valve cover rest on the top side of the tray deck in order to hold the valve cover in place.
    Type: Application
    Filed: November 26, 2007
    Publication date: May 28, 2009
    Inventors: Bartele Griepsma, Mark W. Pilling, Raymond Pluss, Daniel Summers
  • Publication number: 20080233611
    Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
    Type: Application
    Filed: October 27, 2005
    Publication date: September 25, 2008
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Peter G. Schultz, Lital Alfonta, Jonathan R. Chittuluru, Alexander Deiters, Dan Groff, Daniel Summerer, Meng-Lin Tsao, Jiangyun Wang, Ning Wu, Jianming Xie, Huaqiang Zeng