Patents by Inventor Daniel Szalay

Daniel Szalay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Collision surface for improved ionisation
    Patent number: 11049708
    Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: June 29, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Steven Derek Pringle, Emrys Jones, Ian Trivett, Stephen O'Brien, Anthony Hesse, Matt Henderson, Alvin Chua, Zoltan Takáts
  • Physically guided rapid evaporative ionisation mass spectrometry (“REIMS”)
    Patent number: 11037774
    Abstract: A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 15, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Emrys Jones, Michael Raymond Morris, Julia Balog, James Ian Langridge, Keith Richardson, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Chemically guided ambient ionisation mass spectrometry
    Patent number: 11031222
    Abstract: A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 8, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Emrys Jones, Michael Raymond Morris, Julia Balog, James Ian Langridge, Keith Richardson, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Ionisation of gaseous samples
    Patent number: 11031221
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 8, 2021
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Capacitively coupled REIMS technique and optically transparent counter electrode
    Patent number: 11031223
    Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: June 8, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Lajos Godorhazy, Daniel Simon, Daniel Szalay, Zoltan Takats, Tamas Karancsi
  • Imaging guided ambient ionisation mass spectrometry
    Patent number: 10978284
    Abstract: A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 13, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Michael Raymond Morris, Julia Balog, Emrys Jones, Keith Richardson, James Ian Langridge, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10971346
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: April 6, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10916415
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 9, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10910206
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: February 2, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Ionisation of gaseous samples
    Patent number: 10840076
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: November 17, 2020
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Ionisation of gaseous samples
    Patent number: 10784096
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: September 22, 2020
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Capacitively coupled REIMS technique and optically transparent counter electrode
    Patent number: 10777399
    Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: September 15, 2020
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Lajos Godorhazy, Daniel Simon, Daniel Szalay, Zoltan Takats, Tamas Karancsi
  • Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
    Patent number: 10777397
    Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: September 15, 2020
    Assignee: Micromass UK Limited
    Inventors: Zoltán Takáts, Júlia Balog, Steven Derek Pringle, Tamás Karancsi, Michael Raymond Morris, Lajos Gödörhazy, Dániel Szalay, Dániel Simon
  • Collision Surface for Improved Ionisation
    Publication number: 20200258729
    Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil- shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
    Type: Application
    Filed: April 29, 2020
    Publication date: August 13, 2020
    Inventors: Tamas KARANCSI, Daniel SIMON, Lajos GODORHAZY, Daniel SZALAY, Steven Derek PRINGLE, Emrys JONES, Ian TRIVETT, Stephen O'BRIEN, Anthony HESSE, Matt HENDERSON, Alvin CHUA, Zoltan TAKÁTS
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10679836
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 9, 2020
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • CAPACITIVELY COUPLED REIMS TECHNIQUE AND OPTICALLY TRANSPARENT COUNTER ELECTRODE
    Publication number: 20200168445
    Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.
    Type: Application
    Filed: January 31, 2020
    Publication date: May 28, 2020
    Inventors: Steven Derek Pringle, Lajos Godorhazy, Daniel Simon, Daniel Szalay, Zoltan Takats, Tamas Karancsi
  • INLET INSTRUMENTATION FOR ION ANALYSER COUPLED TO RAPID EVAPORATIVE IONISATION MASS SPECTROMETRY ("REIMS") DEVICE
    Publication number: 20200075301
    Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
    Type: Application
    Filed: October 31, 2019
    Publication date: March 5, 2020
    Inventors: Zoltán TAKÁTS, Júlia BALOG, Steven Derek PRINGLE, Tamás KARANCSI, Michael Raymond MORRIS, Lajos GÖDÖRHÁZY, Dániel SZALAY, Dániel SIMON
  • Liquid Trap or Separator for Electrosurgical Applications
    Publication number: 20200058478
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Application
    Filed: October 24, 2019
    Publication date: February 20, 2020
    Inventors: Tamas KARANCSI, Lajos GODORHAZY, Daniel SZALAY, Zoltan TAKATS, Julia BALOG, Steven Derek PRINGLE, Daniel SIMON
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10504709
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: December 10, 2019
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Rapid Evaporative Ionisation Mass Spectrometry ("REIMS") and Desorption Electrospray Ionisation Mass Spectrometry ("DESI-MS") Analysis of Swabs and Biopsy Samples
    Publication number: 20190371589
    Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
    Type: Application
    Filed: August 19, 2019
    Publication date: December 5, 2019
    Inventors: Zoltan TAKATS, Emrys JONES, James Ian LANGRIDGE, Michael Raymond MORRIS, Tamas KARANCSI, Steven Derek PRINGLE, Julia BALOG, Daniel SIMON, Lajos GODORHAZY, Daniel SZALAY, Keith RICHARDSON, Phillip Robert BENNETT, David Alan MACINTYRE, Pamela PRUSKI