Abstract: Compositions of ?-lactam antibiotics and branched poly(ethylenimine) (BPEI), and ?-lactam antibiotics and potentiating compounds of polyethylene glycol (PEG)-BPEI conjugates, and methods of their use to treat infections and to remove bacterial biofilms from surfaces of devices and wounds. The BPEI and PEG-BPEI conjugates potentiate the activity of the ?-lactam antibiotics so the compositions have synergistic effects against various Gram-positive bacteria. For example, the compositions can be used to treat Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-resistant Staphylococcus epidermidis (MRSE), that have developed resistance against most ?-lactam antibiotics. The BPEI and PEG-BPEI conjugates result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as ?-lactam antibiotics.

Abstract: The present invention is directed to a polymer electrolyte comprising amine groups dispersed throughout the polymer backbone, including various poly(ethylenimine)-based polymers, which enable ionic movement for use in various applications, including for example batteries, fuel cells, sensors, supercapacitors and electrochromic devices. The present invention is further directed to a method for preparing such polymer electrolytes.

Abstract: The present invention is directed to a polymer electrolyte comprising amine groups dispersed throughout the polymer backbone, including various poly(ethylenimine)-based polymers, which enable ionic movement for use in various applications, including for example batteries, fuel cells, sensors, supercapacitors and electrochromic devices. The present invention is further directed to a method for preparing such polymer electrolytes.