Abstract: Intravenous plasma derivatives having an acceptably lowered content of externally caused deleterious activity or exogenous activity, and their method of production are provided. The method includes the steps of mixing bentonite and an aqueous solution of plasma derivative containing exogenous activity, the bentonite and the mixing time being sufficient to adsorb exogenous activity, and isolating the aqueous phase from the bentonite. Optionally, for the removal of residual exogenous activity, the step of treatment of the aqueous phase with bentonite is repeated and/or the bentonite-treated aqueous phase is further purified by ion-exchange chromatography.

Abstract: Antihemophilic factor (AHF) concentrate having enhanced potency and solubility and its process of production are provided. The process includes the steps of removing unwanted protein from an aqueous extract of antihemophilic blood plasma cryoprecipitate by mixing the aqueous extract with aluminum hydroxide at an acid pH in the cold, adjusting the purified aqueous extract to an acid pH and freeze-drying the extract, optionally removing water from the extract just before freeze-drying.