Patents by Inventor Daniel T. Smithey

Daniel T. Smithey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPRAY-DRIED FORMULATION OF A PYRIDAZINONE TRPC5 INHIBITOR
    Publication number: 20220183981
    Abstract: Disclosed are spray-dried formulations of 4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)pyridazin-3(2H)-one, methods and compositions for making the same, and solid dosage forms comprising the same. The dosage forms described herein are useful in methods of treating kidney diseases or neuropathies associated with diseases or conditions, and in methods of treating pain, anxiety, or depression.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 16, 2022
    Inventors: Donald T. Corson, Elizabeth Chu Kwong, Thomas E. Stumpfig, Daniel T. Smithey, Erica B. Schlesinger
  • Pharmaceutical compositions of dextran polymer derivatives
    Patent number: 9757464
    Abstract: Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: September 12, 2017
    Assignee: Bend Research, Inc.
    Inventors: Warren K. Miller, David T. Vodak, Daniel E. Dobry, David K. Lyon, Dwayne T. Friesen, Michael M. Morgen, Corey J. Bloom, Daniel T. Smithey
  • Pharmaceutical dosage forms comprising a low-solubility drug and a polymer
    Patent number: 9445998
    Abstract: A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: September 20, 2016
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, Walter C. Babcock, Dwayne T. Friesen, Roderick J. Ray, Daniel T. Smithey, Sheri L. Shamblin, Ravi M. Shanker
  • Pharmaceutical compositions with enhanced performance
    Patent number: 9387252
    Abstract: Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: July 12, 2016
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, Warren K. Miller, Daniel T. Smithey, David K. Lyon
  • Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
    Patent number: 9023393
    Abstract: A pharmaceutical composition comprises a solid adsorbate comprising a drug adsorbed onto a substrate and a lipophilic microphase-forming material. The solid adsorbate may also be co-administered with a lipophilic microphase-forming material to an in vivo use environment. The compositions of the present invention enhance the concentration of drug in a use environment.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: May 5, 2015
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • PHARMACEUTICAL DOSAGE FORMS COMPRISING A LOW-SOLUBILITY DRUG AND A POLYMER
    Publication number: 20150064264
    Abstract: A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Applicant: Bend Research, Inc.
    Inventors: Leah E. Appel, Walter C. Babcock, Dwayne T. Friesen, Roderick J. Ray, Daniel T. Smithey, Sheri L. Shamblin, Ravi M. Shanker
  • PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE
    Publication number: 20140171441
    Abstract: Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.
    Type: Application
    Filed: December 17, 2013
    Publication date: June 19, 2014
    Applicant: BEND RESEARCH, INC.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, Warren K. Miller, Daniel T. Smithey
  • PHARMACEUTICAL COMPOSITIONS OF DEXTRAN POLYMER DERIVATIVES
    Publication number: 20140161895
    Abstract: Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 12, 2014
    Applicant: Bend Research, Inc.
    Inventors: Warren K. Miller, David T. Vodak, Daniel E. Dobry, David K. Lyon, Dwayne T. Friesen, Michael M. Morgen, Corey J. Bloom, Daniel T. Smithey
  • Pharmaceutical compositions of adsorbates of amorphous drug
    Patent number: 8703199
    Abstract: Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: April 22, 2014
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey, Ralph Tadday
  • Pharmaceutical compositions of dextran polymer derivatives
    Patent number: 8685458
    Abstract: Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: April 1, 2014
    Assignee: Bend Research, Inc.
    Inventors: Warren K. Miller, David T. Vodak, Daniel E. Dobry, David K. Lyon, Dwayne T. Friesen, Michael M. Morgen, Corey J. Bloom, Daniel T. Smithey
  • Solid dispersion formulations and methods of use thereof
    Patent number: 8591944
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: November 26, 2013
    Assignee: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
    Publication number: 20130231350
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Application
    Filed: April 1, 2013
    Publication date: September 5, 2013
    Applicant: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • Pharmaceutical compositions of semi-ordered drugs and polymers
    Patent number: 8491933
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: July 23, 2013
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • Solid dispersion formulations and methods of use thereof
    Patent number: 8409560
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: April 2, 2013
    Assignee: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • Pharmaceutical compositions of adsorbates of amorphous drug
    Patent number: 8389006
    Abstract: Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: March 5, 2013
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey, Ralph Tadday
  • SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
    Publication number: 20130035345
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Application
    Filed: March 7, 2012
    Publication date: February 7, 2013
    Applicant: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • PHARMACEUTICAL COMPOSITIONS OF SEMI-ORDERED DRUGS AND POLYMERS
    Publication number: 20120322805
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Application
    Filed: August 23, 2012
    Publication date: December 20, 2012
    Applicant: BEND RESEARCH, INC.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
    Publication number: 20120252819
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Application
    Filed: June 12, 2012
    Publication date: October 4, 2012
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • Pharmaceutical compositions of semi-ordered drugs and polymers
    Patent number: 8257739
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: September 4, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
    Patent number: RE47033
    Abstract: A pharmaceutical composition comprises a solid adsorbate comprising a drug adsorbed onto a substrate and a lipophilic microphase-forming material. The solid adsorbate may also be co-administered with a lipophilic microphase-forming material to an in vivo use environment. The compositions of the present invention enhance the concentration of drug in a use environment.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: September 11, 2018
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey