Abstract: The present invention provides methods for treating patients with ccRCC and other VHL(?) cancers, the method comprising administering to the patient a therapeutically effective amount of a protein kinase inhibitor and a therapeutically effective amount of at least a second agent comprising bisantrene or a derivative thereof, or a pharmaceutically acceptable salt of bisantrene or derivative thereof. Also provided by the present invention are pharmaceutical compositions and kits for the treatment of ccRCC and other VHL(?) cancers as well as the use of such compositions for the manufacture of medicaments for the treatment of ccRCC and other VHL(?) cancers.

Abstract: The present invention relates to methods comprising administering to the subject an effective amount of a cardioprotective agent comprising bisantrene or a derivative thereof, or a pharmaceutically acceptable salt of bisantrene or derivative thereof.

Abstract: The present invention relates to DNA and polypeptide constructs and related methods useful for sequestering and/or purifying polypeptides. In particular, the invention relates to hybrid polypeptides comprising a polypeptide of interest linked to a polymerisable polypeptide, a method of sequestering and/or purifying a polypeptide of interest using the hybrid polypeptide and related hybrid nucleic acids, transformed cells and libraries.

Abstract: The present invention relates to the optimization of primer libraries. Shorter primers are annealed to template sequences and extended in order to provide primers having improved specificity. The primers of the invention have utility in DNA amplification and sequencing methods.

Abstract: The present invention relates to a method of performing a chemical reaction, in particular a small-scale chemical reaction. The method involves the use of two (or more) phases which, when formed into an emulsion, have the characteristic of being subject to “collapse” under certain physical or chemical conditions such that the discontinuous phase dispersed in the emulsion becomes a substantially continuous phase—the chemical reaction taking place in the newly-formed continuous phase.

Abstract: The present invention relates generally to genetic analysis and, in particular, to genomics. More specifically, the invention relates to a method of amplification of a nucleic acid (or a nucleotide sequence of interest) which may be applied to sequencing in general and, in particular, to genome sequencing.