Abstract: Among other things, the present disclosure provides various useful agents. In some embodiments, provided agents can bind to beta-catenin. In some embodiments, the present disclosure provides technologies for modulating beta-catenin functions. In some embodiments, the present disclosure provides technologies for preventing and/or treating conditions, disorders or diseases associated with beta-catenin. In some embodiments, the present disclosure provides designed amino acids and agents which can provide improved properties and/or activities.

Abstract: A guidewire comprising: a core wire defining a longitudinal axis; and an elongated body extending along the longitudinal axis, the elongated body defining: an inner lumen configured to retain a distal portion of the core wire and a plurality of openings, wherein each opening of the plurality of openings defines an arc defining a radius of curvature and a concave portion facing a distal end of the elongated body or a proximal end of the elongated body, and wherein the radii of curvature of the plurality of openings varies along the longitudinal axis.

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

Abstract: A computer-implemented method for operating a technical device using a model based on artificial intelligence by a client of a client-server system, wherein each client stores a client model for operating a technical device, where a global model is provided to a client based on federated learning, and where the technical device is operated using the client model and sensitive parameter.

Abstract: Systems, methods, and devices provide low-power wakeup operations for wireless devices. Methods include receiving an audio signal from a first wireless device at a second wireless device via an audio transducer, the audio signal including a plurality of encoded data values, and determining, using a processing device of the second wireless device, if the received audio signal includes a valid wakeup code. Methods also include transitioning a transceiver of the second wireless device from a sleep mode to a wake mode in response to determining that the audio signal includes a valid wakeup signal.

Abstract: Particular embodiments described herein provide for an electronic device that can be configured to include a system condition engine and non-volatile memory. The system condition engine is configured to monitor a condition associated with an electronic device and non-volatile memory. The non-volatile memory can store a predetermined specification range or a specification threshold for the condition and when the condition is outside of the predetermined specification range or exceeds the specification threshold, the system condition engine can record that the condition was outside of the predetermined specification range or exceeded the specification threshold in the non-volatile memory. In an example, the non-volatile memory may be a fuse, especially a field programmable fuse.

Abstract: According to some embodiments, an enterprise proprietary data store contains a set of electronic data records, each electronic data record having with proprietary data and an associated governance structure. A compliance computer platform may receive the proprietary data and associated governance structure from the enterprise proprietary data store and define enterprise-wide decision accountabilities for the proprietary data based on the governance structure. The compliance computer platform may also define privacy objectives for the proprietary data based on the governance structure along with specific machine-level controls to test and confirm compliance with the governance structure.

Abstract: A mattress for a patient support apparatus has a cover having bottom and top surfaces, and an inflatable section disposed between the bottom and top surfaces. The inflatable section has a plurality of upper bladders in fluid communication with each other and a plurality of lower bladders in fluid communication with each other. The upper and lower bladders are selectively inflated independently from each other. The upper and lower bladders are formed by three sheets including an upper sheet, a lower sheet disposed below the upper sheet, and an intermediate sheet disposed between the upper and lower sheets. The upper sheet is fixed to the intermediate sheet to define the upper bladders between the upper sheet and the intermediate sheet. The lower sheet is fixed to the intermediate sheet to define the lower bladders between the lower sheet and the intermediate sheet. Other aspects of the mattress are also disclosed.

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

Abstract: Pharmaceutical compositions and methods of their administration following delivery of such compositions into a fluid-containing chamber of the body are provided. More specifically, pharmaceutical compositions mixed with reactive compositions produce a gas when brought into contact with a bodily fluid, such as that in the cochlear canal; the gas causes a fluidic movement in the chamber and also propels the disintegrating composition containing the therapeutic substance in the fluid to the apical region of the canal where the therapeutic substance contacts the tissue walls of the chamber, leading to various effects on or in cells of the tissue surrounding the fluid in that region. Methods disclosed may be used for delivery of pharmaceutical compositions to other fluid-containing chambers of the body for treatment of tissues in difficult-to-reach areas, and may be especially useful in chambers in which there is limited fluid movement.

Abstract: In a leak detection device comprising a gas analyzer, a vacuum pump, a first gas inlet, and a second gas inlet, it is provided that a first multi-way valve is connected to a first inlet and at least a first and a second outlet, wherein the inlet is connected to the first gas inlet, a second multi-way valve is connected to first inlet and at least a first and a second outlet, wherein the inlet is connected to the second gas inlet, wherein the two first outlets of the two multi-way valves are connected to the gas analyzer, and the two second outlets of the two multi-way valves are connected to the vacuum pump.

Abstract: Disclosed herein are systems and methods for determining data structures. In some embodiments, a classifier may be used to determine one or more attributes of an entity. In some embodiments, a clustering algorithm may be used to determine an attribute cluster. In some embodiments, an impact metric machine learning model may be used to determine an outlier cluster. In some embodiments, an outlier process may be determined as a function of the outlier cluster. In some embodiments, a visual element may be determined as a function of an outlier process and may be displayed to a user.

Abstract: A windshield including a first side edge, a second side edge, a front edge, and a rear edge. A central portion of the front edge is raised relative to the first side edge and the second side edge. A notch extends from the front edge towards the rear edge and has an open end at the front edge and a closed end spaced apart from the open end. A mounting hole is closer to the first side edge than the second side edge, and a second mounting hole is closer to the second side edge than the first side edge. The front edge is configured to conform to a contour of a panel, the notch is configured to engage with a bracket that extends from the panel, and each of the first and second mounting holes is configured to receive a fastener to secure the windshield to the panel.

Abstract: Systems, methods and articles of manufacture provide for an injection management platform that allows the verification and management of injection event transactions involving injectors equipped with NFC or RFID chips utilizing a distributed and secure technology such as blockchain. An injection event transaction ledger allows for digital receipts of injection event transactions to be securely verified and updated. In accordance with some embodiments, injectors may comprise blow-fill-seal (BFS) injectors that are pre-filled with a single dose of a fluid agent comprising a vaccine or medicament, allowing for tracking of individual doses of the fluid agent via the injection event transaction ledger.

Abstract: A sheet assembly for positioned a patient includes a base sheet a first handle interface, and a second handle interface. The base sheet defines a first axis extending in a direction parallel to a width of the base sheet and a second axis extending in a direction parallel to a length of the base sheet. The base sheet has a first end on a first side of the first axis and a second end on a second side of the first axis. The first handle interface is positioned on the first end of the base sheet. The first handle interface defines a first opening configured to receive a hand of an operator of the sheet assembly. The second handle interface is positioned on the second end of the base sheet. The second handle interface defines a second opening configured to receive the hand.

Abstract: A tractor has a processor and memory storing machine-readable instructions that, when executed by the processor, cause the processor to: select at least one image captured by a camera of a parking spot being passed by the tractor when a point-of-interest (POI) of the parking spot is most centered within a field of view of the camera, store the image in the memory in association with the parking spot, determine that the parking spot is occupied after a costmap for the parking spot is populated by the LIDAR, retrieve the image corresponding to the parking spot from the memory, determine, from the image, a trailer identifier of a trailer parked in the parking spot; and send a message defining the parking spot and the trailer identifier to an inventory service for use in updating a yard inventory.

Abstract: An ultrasonic device is provided. The ultrasonic device includes at least one micromachined ultrasonic transducer (MUT) and processing circuitry electrically coupled to the at least one MUT. The at least one MUT and the processing circuitry are packed in an embedded wafer level ball grid array (eWLB) package. An acoustic coupling medium for acoustic coupling of the at least one MUT to an external application surface is formed on the at least one MUT.

Abstract: A sortation system is disclosed that includes a programmable motion device including an end effector, a perception system for recognizing any of the identity, location, and orientation of an object presented in a plurality of objects, a grasp selection system for selecting a grasp location on the object, the grasp location being chosen to provide a secure grasp of the object by the end effector to permit the object to be moved from the plurality of objects to one of a plurality of destination locations, and a motion planning system for providing a motion path for the transport of the object when grasped by the end effector from the plurality of objects to the one of the plurality of destination locations, wherein the motion path is chosen to provide a path from the plurality of objects to the one of the plurality of destination locations.

Abstract: A rapid and automatic virus imaging and analysis system includes (i) electron optical sub-systems (EOSs), each of which has a large field of view (FOV) and is capable of instant magnification switching for rapidly scanning a virus sample; (ii) sample management sub-systems (SMSs), each of which automatically loads virus samples into one of the EOSs for virus sample scanning and then unloads the virus samples from the EOS after the virus sample scanning is completed; (iii) virus detection and classification sub-systems (VDCSs), each of which automatically detects and classifies a virus based on images from the EOS virus sample scanning; and (iv) a cloud-based collaboration sub-system for analyzing the virus sample scanning images, storing images from the EOS virus sample scanning, and storing and analyzing machine data associated with the EOSs, the SMSs, and the VDCSs.

Abstract: A portable eyewear electronic device that includes a speaker module and methods of assembly of the device are presented. The electronic eyewear device includes a speaker module that emits acoustic radiation that is channeled through a carrier contained within a temple to one or more acoustic ports near a user's ear.