Patents by Inventor Daniel Topgaard

Daniel Topgaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150130458
    Abstract: The present invention describes a method for quantifying microscopic diffusion anisotropy and/or mean diffusivity in a material by analysis of echo attenuation curves acquired with two different gradient modulations schemes, wherein one gradient modulation scheme is based on isotropic diffusion weighting and the other gradient modulation scheme is based on non-isotropic diffusion weighting, and wherein the method comprises analyzing by comparing the signal decays of the two acquired echo attenuation curves.
    Type: Application
    Filed: May 3, 2013
    Publication date: May 14, 2015
    Inventors: Daniel Topgaard, Samo Lasic, Markus Nilsson
  • Publication number: 20150115957
    Abstract: The present invention describes a method for magnetic resonance (MR) and/or MR imaging, comprising acquisition of signals and MR images originating from a RF and gradient sequence causing isotropic diffusion weighting of signal attenuation, wherein the isotropic diffusion weighting is achieved by one time-dependent dephasing vector q(t) having an orientation, wherein the isotropic diffusion weighting is proportional to the trace of a diffusion tensor D, and wherein the orientation of the time-dependent dephasing vector q(t) is either varied discretely in more than three directions in total, or changed continuously, or changed in a combination of discretely and continuously during the gradient pulse sequence, 0?t?echo time, where t represents the time. The method may be performed during a single shot (single MR excitation).
    Type: Application
    Filed: May 3, 2013
    Publication date: April 30, 2015
    Inventors: Daniel Topgaard, Samo Lasic, Markus Nilsson
  • Patent number: 8810244
    Abstract: The present invention refers to a method for magnetic resonance imaging or nuclear magnetic resonance spectroscopy comprising emitting a radio frequency and gradient pulse sequence towards an object being subjected to a magnetic field, wherein said object comprises a molecule having an atom with a nuclear spin differing from 0, encoding, detecting and acquiring a magnetic resonance signal from said object corresponding to said emitted radio frequency and gradient pulse sequence, wherein the radio frequency and gradient pulse sequence comprises a first weighting block, a mixing block with duration tm and a second weighting block, and wherein encoding, detecting and acquiring the magnetic resonance signal from said object is limited to initial decay of the signal intensity I with increasing strength of at least one of the first weighting block and the second weighting block, wherein the variation of the initial signal decay rate with tm is analysed to obtain the apparent exchange rate AXR.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: August 19, 2014
    Assignee: CR Development AB
    Inventor: Daniel Topgaard
  • Patent number: 8565854
    Abstract: A method, system, computer-readable medium, use, and pulse sequence for magnetic resonance imaging or nuclear magnetic resonance is provided for determining the rate of molecular exchange between components with different diffusion characteristics. The present invention encodes the magnetic resonance signal for exchange utilizing judiciously designed protocols for varying the parameters of a pulse sequence comprising a pair of diffusion weighting blocks separated by a mixing time.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: October 22, 2013
    Assignee: CR Development AB
    Inventors: Karin Bryskhe, Daniel Topgaard, Anna Stenstam
  • Publication number: 20120062229
    Abstract: The present invention refers to a method for magnetic resonance imaging or nuclear magnetic resonance spectroscopy comprising emitting a radio frequency and gradient pulse sequence towards an object being subjected to a magnetic field, wherein said object comprises a molecule having an atom with a nuclear spin differing from 0, encoding, detecting and acquiring a magnetic resonance signal from said object corresponding to said emitted radio frequency and gradient pulse sequence, wherein the radio frequency and gradient pulse sequence comprises a first weighting block, a mixing block with duration tm and a second weighting block, and wherein encoding, detecting and acquiring the magnetic resonance signal from said object is limited to initial decay of the signal intensity I with increasing strength of at least one of the first weighting block and the second weighting block, wherein the variation of the initial signal decay rate with tm is analysed to obtain the apparent exchange rate AXR.
    Type: Application
    Filed: April 22, 2010
    Publication date: March 15, 2012
    Applicant: CR DEVELOPMENT AB
    Inventor: Daniel Topgaard
  • Publication number: 20100152567
    Abstract: A method, system, computer-readable medium, use, and pulse sequence for magnetic resonance imaging or nuclear magnetic resonance is provided for determining the rate of molecular exchange between components with different diffusion characteristics. The present invention encodes the magnetic resonance signal for exchange utilizing judiciously designed protocols for varying the parameters of a pulse sequence comprising a pair of diffusion weighting blocks separated by a mixing time.
    Type: Application
    Filed: May 30, 2008
    Publication date: June 17, 2010
    Inventors: Karin Bryskhe, Daniel Topgaard, Anna Stenstam
  • Patent number: 7439738
    Abstract: Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: October 21, 2008
    Assignee: The Regents of The University of California
    Inventors: Alexander Pines, Daniel Topgaard, Dimitrios Sakellariou, Rachel W. Martin, Carlos A. Meriles
  • Publication number: 20070194788
    Abstract: Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.
    Type: Application
    Filed: January 19, 2007
    Publication date: August 23, 2007
    Inventors: Alexander Pines, Daniel Topgaard, Dimitrios Sakellariou, Rachel Martin, Carlos Meriles