Abstract: 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: Pyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of pyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: 7H-Pyrrolo[2,3-d]pyrimidine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: Pyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of pyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: A liquid treatment system and methods for removing contaminants from a liquid flow is disclosed. The treatment system having a treatment zone, a nanobubble diffuser system and a skimmer cassette assembly configured to remove the nanobubble and contaminant agglomeration from the liquid flow. The nanobubble diffuser system configured to diffuse negatively charged nanobubbles into the liquid flow whereby the nanobubbles adhere to positively charged contaminants and the nanobubble and contaminant agglomeration is urged to float towards a surface of the liquid flow in the treatment zone and be removed by the skimmer cassette assembly. In some embodiments, larger bubble diffuse systems are provided to increase the rise rate of contaminants. In some embodiments, the treatment system is a floating vessel. In some embodiments, the treatment system is configured to remove microplastics down to a size of about 1 mm and less.

Abstract: 4-Aminopyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-aminopyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, and osteoarthritis).

Abstract: An update to an encoder is implemented utilizing information regarding performance of a reinforcement learning (RL) agent. This allows the emphasis to be placed not only on improving the performance of the RL agent, but on providing that the data within the encoding is both required and in such a form that it is optimal for the RL agent to learn, thereby reducing complexity and increasing speed of learning.

Abstract: 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: Pyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of pyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer’s disease, diabetes, viral infections, and osteoarthritis).

Abstract: A procedure to train an online scheduling system using Reinforcement Learning agents to process any kind of product variant and any kind of machine configuration is disclosed. The novel approach of scheduling jobs or products in a flexible manufacturing system is to train Deep Reinforcement Learning agents with generated training data. One agent may represent a product and may autonomously guide the product through the manufacturing system, including decisions regarding resource allocations (which module should process which operation) and transport decisions. Dependent on the mode to be trained, the identical job-specification for same, job-specifications from the same cluster for similar, and job-specifications from different clusters for different are chosen. This solution may handle any product variant to be produced within the considered system.

Abstract: Methods and systems are provided for concave footpads for a personal transport device. In one example, the concave footpads may be coupled to the personal transport device, arranged between an operator's feet and an upper surface of the personal transport device, the upper surface including a pressure transducer.

Abstract: 7H-Pyrrolo[2,3-d]pyrimidine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: A method of manufacturing a composite (e.g. fibre-reinforced polymer) connector for a fluid transfer conduit includes: providing a tubular mandrel which extends substantially parallel to a central axis C; providing a former on the tubular mandrel which extends substantially perpendicular to the central axis C; and winding continuous fibre reinforcement, impregnated with a thermosetting polymer, around the mandrel to form a tubular hub portion which extends substantially parallel to the central axis C and over the former to form a flange portion 308 which extends from the hub portion at an angle to the central axis C. Winding the continuous fibre reinforcement over the former includes passing the continuous fibre reinforcement across a first surface of the former that is substantially perpendicular to the central axis C and across a second surface of the former such that the former is encapsulated as a core for the flange portion.

Abstract: The method for self-learning manufacturing scheduling for a flexible manufacturing system (FMS) with processing entities that are interconnected through handling entities is disclosed. The manufacturing scheduling is learned by a reinforcement learning system on a model of the flexible manufacturing system. The model represents at least the behavior and the decision making of the flexible manufacturing system, and the model is transformed in a state matrix to simulate the state of the flexible manufacturing system. A self-learning system for online scheduling and resource allocation is also provided. The system is trained in a simulation and learns the best decision from a defined set of actions for many every situation within an FMS. A decision may be made in near real-time during a production process and the system finds the optimal way through the FMS for every product using different optimization goals.

Abstract: A liquid treatment system and methods for removing contaminants from a liquid flow is disclosed. The treatment system having a treatment zone, a nanobubble diffuser system and a skimmer cassette assembly configured to remove the nanobubble and contaminant agglomeration from the liquid flow. The nanobubble diffuser system configured to diffuse negatively charged nanobubbles into the liquid flow whereby the nanobubbles adhere to positively charged contaminants and the nanobubble and contaminant agglomeration is urged to float towards a surface of the liquid flow in the treatment zone and be removed by the skimmer cassette assembly. In some embodiments, larger bubble diffuse systems are provided to increase the rise rate of contaminants. In some embodiments, the treatment system is a floating vessel. In some embodiments, the treatment system is configured to remove microplastics down to a size of about 1 mm and less.

Abstract: Methods and systems are provided for concave footpads for a personal transport device. In one example, the concave footpads may be coupled to the personal transport device, arranged between an operator's feet and an upper surface of the personal transport device, the upper surface including a pressure transducer.

Abstract: An agricultural harvester includes a chassis; a threshing and separating system carried by the chassis and including at least one threshing rotor mounted in a longitudinal direction of the agricultural harvester; a grain pan carried by the chassis that receives crop material from the threshing and separating system, the grain pan being configured to shake in a fore-to-aft direction and a lateral direction; and a cleaning system carried by the chassis supplied with crop material from the grain pan, the cleaning system including at least one sieve configured to shake in the lateral direction out of phase with the grain pan.