Abstract: A tool for assessing treatment options within a risk-benefit space (plotting risk against benefit) and provides a superimposed boundary indicating patient risk-benefit preference for assessment of these options. The patient risk-benefit preference can be used to identify a preferred treatment option, and interactive controls can be provided to change risk-benefit preference, risk categories, benefit categories, disease type, and the like.

Abstract: A method and related topical skin preparation comprising an extract from Ephedra viridis. The disclosed method and preparation treat fever blisters caused by herpes simplex virus and other skin-related inflammatory conditions.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: A tool for assessing treatment options within a risk-benefit space (plotting risk against benefit) and provides a superimposed boundary indicating patient risk-benefit preference for assessment of these options. The patient risk-benefit preference can be used to identify a preferred treatment option, and interactive controls can be provided to change risk-benefit preference, risk categories, benefit categories, disease type, and the like.

Abstract: Systems and methods are disclosed for providing a secure communication between a first network and a second network. The method may include receiving, at a Secure Access Smart Hub (SASH), a signal from the first network requesting a communication connection; establishing a first connection between the first network and the SASH; establishing a second connection between the SASH and the second network; receiving, at the SASH, data from the first network having a first protocol; translating the data having the first protocol into data having a second protocol; and transmitting the data from the SASH to the second network.

Abstract: A gas turbine engine that includes a turbine interstage region. The turbine interstage region is configured to conduct bore bleed air outwardly. The interstage region includes a central plenum. The interstage region also includes a first mid-seal and a second mid-seal. The central plenum is fluidly connected to bore bleed air by a flow circuit that passes between the first mid-seal and the second mid-seal.

Abstract: The embodiments herein describe a mode of applications on the portable electronic device that improves single-handed operation of the devices. For example, the embodiments herein describe an ergonomic mode of an application that displays the graphical user interface (GUI) of the application in a bottom area of the display screen of the electronic device to allow the user to more easily interact with objects. The embodiments herein also describe an ergonomic mode of a keyboard displayed on the display screen of the portable electronic device. During the ergonomic mode of the keyboard, the keyboard is shifted towards a vertical edge of the display screen to allow a user to more easily reach keys of the keyboard that were previously unreachable without the user switching to two handed operation of the device or repositioning the electronic device in the user's hand.

Abstract: Systems and methods are disclosed for providing a secure communication between a first network and a second network. The method may include receiving, at a Secure Access Smart Hub (SASH), a signal from the first network requesting a communication connection; establishing a first connection between the first network and the SASH; establishing a second connection between the SASH and the second network; receiving, at the SASH, data from the first network having a first protocol; translating the data having the first protocol into data having a second protocol; and transmitting the data from the SASH to the second network.

Abstract: An apparatus and method for a turbine engine including an engine core having a compressor section, a combustor, and a turbine section, which are arranged to define a stator and rotor. The engine further includes a swirler to increase the rotational speed of the air leaving the stator and entering the interior of the rotor.

Abstract: A turbine interstage structure for a gas turbine engine that includes a first stage disk and a second stage disk. A central plenum is defined by a an inner band for supporting nozzle vanes, a forward stator plate and an aft stator plate wherein the forward stator plate is spaced-apart from the aft stator plate, and an inner boundary. A forward mid-seal positioned between the inner boundary and the forward stator plate. An aft mid-seal positioned between the inner boundary and the aft stator plate; and wherein the inner boundary is a solid annular component.

Abstract: The embodiments herein describe a mode of applications on the portable electronic device that improves single-handed operation of the devices. For example, the embodiments herein describe an ergonomic mode of an application that displays the graphical user interface (GUI) of the application in a bottom area of the display screen of the electronic device to allow the user to more easily interact with objects. The embodiments herein also describe an ergonomic mode of a keyboard displayed on the display screen of the portable electronic device. During the ergonomic mode of the keyboard, the keyboard is shifted towards a vertical edge of the display screen to allow a user to more easily reach keys of the keyboard that were previously unreachable without the user switching to two handed operation of the device or repositioning the electronic device in the user's hand.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: The embodiments herein describe a mode of applications on the portable electronic device that improves single-handed operation of the devices. For example, the embodiments herein describe an ergonomic mode of an application that displays the graphical user interface (GUI) of the application in a bottom area of the display screen of the electronic device to allow the user to more easily interact with objects. The embodiments herein also describe an ergonomic mode of a keyboard displayed on the display screen of the portable electronic device. During the ergonomic mode of the keyboard, the keyboard is shifted towards a vertical edge of the display screen to allow a user to more easily reach keys of the keyboard that were previously unreachable without the user switching to two handed operation of the device or repositioning the electronic device in the user's hand.

Abstract: A gas turbine engine that includes a turbine interstage region. The turbine interstage region is configured to conduct bore bleed air outwardly. The interstage region includes a central plenum. The interstage region also includes a first mid-seal and a second mid-seal. The central plenum is fluidly connected to bore bleed air by a flow circuit that passes between the first mid-seal and the second mid-seal.

Abstract: An apparatus and method for a turbine engine including an engine core having a compressor section, a combustor, and a turbine section, which are arranged to define a stator and rotor. The engine further includes a swirler to increase the rotational speed of the air leaving the stator and entering the interior of the rotor.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A gas turbine engine that includes a turbine interstage region. The turbine interstage region is configured to conduct bore bleed air outwardly. The interstage region includes a central plenum. The interstage region also includes a first mid-seal and a second mid-seal. The central plenum is fluidly connected to bore bleed air by a flow circuit that passes between the first mid-seal and the second mid-seal.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: A radiation detector including a scintillator; a wavelength shifting portion to cause a wavelength shift in photons emitted by the scintillator; and a photodetector optically coupled to the scintillator to receive the wavelength shifted photons.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.