Abstract: The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.

Abstract: The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.

Abstract: Chitosan-nucleic acid polyplex compositions containing a reversibly bound polymer coat comprising linear block copolymers with a polyanionic anchor region and at least one polyethylene glycol tail region are described herein. In some cases, the compositions exhibit improved stability and/or mucosal diffusion as compared to uncoated particles. In some cases, the reversibly bound polymer coat does not interfere with, or enhances, transfection of target cells or tissues as compared to uncoated particles.

Abstract: The present disclosure relates to methods and compositions comprising derivatized-chitosan polyplexes reversibly coated with a polyanion-containing block co-polymer for the localized expression of IL-12 in mucosal tissues, preferably in combination with an IFN-1 activator/inducer, for use in cancer immunotherapy.

Abstract: The present application relates to a freeze-dried polymer composition containing chitosan and at least one lyoprotectant, a process for preparing a freeze-dried composition containing chitosan and at least one lyoprotectant and the use of a reconstituted freeze-dried chitosan composition to prepare implants for tissue repair.

Abstract: The present application relates to a freeze-dried polymer composition containing chitosan and at least one lyoprotectant, a process for preparing a freeze-dried composition containing chitosan and at least one lyoprotectant and the use of a reconstituted freeze-dried chitosan composition to prepare implants for tissue repair.

Abstract: The present disclosure relates to a nucleic acid delivery composition comprising a coated chitosan-based polyplex, wherein the coated chitosan-based polyplex comprises: a chitosan; an isolated nucleic acid; and an additional polyelectrolyte. The coated chitosan-based polyplex has an initial or a final molar ratio of amine groups of chitosan (N) to phosphate groups of the nucleic acid (P) to carboxyl groups of the additional polyelectrolyte (C) (N:P:C), wherein the N has a value between about 1.0 and about 10.5, the P has a value between about 1.0 and about 2.0 and the C has a value between about 1.0 and 10.5.

Abstract: The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.

Abstract: The present application relates to a freeze-dried polymer composition containing chitosan and at least one lyoprotectant, a process for preparing a freeze-dried composition containing chitosan and at least one lyoprotectant and the use of a reconstituted freeze-dried chitosan composition to prepare implants for tissue repair.

Abstract: The present invention relates to a polyelectrolyte complex composition comprising a polymer, a nucleic acid molecule, a lyoprotectant, and a buffer. The polyelectrolyte complex composition preserving the biological activities of the polyelectrolyte complex following freeze-drying and rehydration.

Abstract: The present document describes a LED lighting module forming part of a LED lighting system comprising a troffer, the LED lighting module comprising: a mounting surface comprising a first end and a second end; light emitting diodes (LEDs) located on the mounting surface; a LED module electrical connector assembly located proximate the first end, the LED module electrical connector assembly for releasably connecting to an electrical retrofit connector assembly located proximate a first end of the troffer, the LED module electrical connector assembly for electrically connecting to the LEDs; and a LED module mechanical connector assembly located proximate the second end for releasably connecting to a mechanical connector assembly located proximate a second end of the troffer, the LED module mechanical connector assembly for releasably and mechanically connecting the LED lighting module to the troffer.

Abstract: The present document describes a LED lighting module forming part of a LED lighting system comprising a troffer, the LED lighting module comprising: a mounting surface comprising a first end and a second end; light emitting diodes (LEDs) located on the mounting surface; a LED module electrical connector assembly located proximate the first end, the LED module electrical connector assembly for releasably connecting to an electrical retrofit connector assembly located proximate a first end of the troffer, the LED module electrical connector assembly for electrically connecting to the LEDs; and a LED module mechanical connector assembly located proximate the second end for releasably connecting to a mechanical connector assembly located proximate a second end of the troffer, the LED module mechanical connector assembly for releasably and mechanically connecting the LED lighting module to the troffer.