Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Abstract: The present invention provides antagonizing antibodies that bind to IL-6, fusion proteins thereof with VEGF Trap, and conjugates of either thereof, and methods of using same. The anti-IL-6 antibodies can be used therapeutically alone or in combination with other therapeutics to diseases.

Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.

Abstract: The present invention provides antagonizing antibodies that bind to IL-6, fusion proteins thereof with VEGF Trap, and conjugates of either thereof, and methods of using same. The anti-IL-6 antibodies can be used therapeutically alone or in combination with other therapeutics to diseases.

Abstract: Provided herein are embodiments relating to treating various eye disorders, including, for example, wAMD, DME, RVO, and DR.

Abstract: The present disclosure provides VEGF Traps and antagonizing antibodies that bind to IL-6, and fusion proteins and conjugates thereof, and methods of using same. The anti-IL-6 antibodies and VEGF Traps, and fusion proteins and conjugates thereof, can be used therapeutically alone or in combination with other therapeutics to treat diseases, symptoms thereof, and/or disorders related thereto.

Abstract: The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.

Abstract: Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and/or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate that includes a polymeric moiety that extends the half-life/effectiveness/properties of the antibody when administered to a subject. A method of the present disclosure includes administering one or more doses of an anti-VEGF antibody conjugate to a subject (e.g., human or other mammalian patient) in need of treating an eye disorder, where the anti-VEGF antibody conjugate may be administered less frequently than a standard anti-VEGF therapy to treat the eye disorder.

Abstract: Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and/or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate that includes a polymeric moiety that extends the half-life/effectiveness/properties of the antibody when administered to a subject. A method of the present disclosure includes administering one or more doses of an anti-VEGF antibody conjugate to a subject (e.g., human or other mammalian patient) in need of treating an eye disorder, where the anti-VEGF antibody conjugate may be administered less frequently than a standard anti-VEGF therapy to treat the eye disorder.

Abstract: Techniques are described herein for presenting attribute variations (differing attribute values) of an item at a network page. A request for the network page associated with an item of an electronic catalog can be received. In response to the request, the network page can be presented. The content and/or format of the network page can be predefined by an interface specification associated with the item and/or item category for the item. The network page may include a first area that includes an expanded view in which one or more variations of the first attribute are depicted and any suitable number of collapsed views in which one or more variations associated with a respective attribute are hidden from view. The areas of the network page may be dynamically expanded and collapsed to enable selection of various attribute values which may then be used to update the network page.

Abstract: Systems and methods for customizing video include providing a portion of video to an electronic display and identifying a character or personality in the portion of video. A request to perform an action regarding the portion of video may be detected and the action may be associated with the identified character or personality. The action may be performed on a second portion of video in response to the character or personality being identified in the second portion of video.

Abstract: The present invention provides antagonizing antibodies that bind to complement factor D (CFD), conjugates thereof, and methods of using same. The anti-CFD antibodies can be used therapeutically alone or in combination with other therapeutics to treat age related macular degeneration and other diseases.

Abstract: Apparatus and associated methods relate to a water dispensing lamp (WDL). In an illustrative example, the WDL may include a base module disposed on a horizontal plane, and a fluid dispensing stem coupled above the horizontal plane along a vertical axis. The fluid dispensing stem, for example, may include an electrical pump and a dispensing element. For example, the electrical pump may be configured to pump fluid out of the dispensing element towards the base module. In some implementations, the WDL may include a lamp shade coupled to the fluid dispensing stem. Various embodiments may advantageously conceal the dispensing element by the lamp shade unless a viewing angle between the horizontal plane and a viewing axis is larger than a predetermined viewing angle threshold.

Abstract: Systems and methods for customizing video include providing a portion of video to an electronic display and identifying a character or personality in the portion of video. A request to perform an action regarding the portion of video may be detected and the action may be associated with the identified character or personality. The action may be performed on a second portion of video in response to the character or personality being identified in the second portion of video.

Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Abstract: A header for a crop harvesting machine includes front and rear wheel arrangements that pivot about respective upright axis between a field orientation and a perpendicular transport orientation, while having respective suspensions arrangements movable between different suspended heights. A biasing spring provides lift assist to carry weight of the wheel arrangement during adjustment of the suspension elevation while being isolated from the suspension once set at any one elevation. The front wheel arrangement includes an anti-rotation latch that locks the front wheel in the field orientation automatically upon disconnection of a hitch arm. A second wheel of the rear wheel arrangement can be held in a raised position relative to a first wheel in a field orientation. Load bearing surfaces between the suspended rear wheels and the header frame abut one another when latching to the header frame to isolate the suspension from the header frame in the transport orientation.

Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Abstract: The present invention provides antagonizing antibodies that bind to complement factor D (CFD), conjugates thereof, and methods of using same. The anti-CFD antibodies can be used therapeutically alone or in combination with other therapeutics to treat age related macular degeneration and other diseases.

Abstract: Presented herein are techniques and systems associated with generating a predicted utilization likelihood for a shared collaboration resource. Integrated resource data associated with a meeting scheduled for a shared collaboration resource is obtained and analyzed using a machine-learned predictive model. The analysis generates a predicted utilization likelihood of the shared resource. An indication of the predicted utilization likelihood is provided to an output system, such as a graphical user interface.

Abstract: Systems and methods for customizing video include providing a portion of video to an electronic display and identifying a character or personality in the portion of video. A request to perform an action regarding the portion of video may be detected and the action may be associated with the identified character or personality. The action may be performed on a second portion of video in response to the character or personality being identified in the second portion of video.