Abstract: The present invention provides a MRI probe of use in detecting and characterizing redox systems in vivo. Also provided are methods of using the probe in MR imaging experiments for diagnosis of disease in a subject, for drug discovery and for probing the redox states of biological systems in vitro.

Abstract: Systems, methods and apparatus are provided through which a compact pod insertable into the rectum for Magnetic Resonance Imaging/Magnetic Resonance Spectroscopy (MRI/MRS) examination of the prostate and containing two receive coils, each connected to transmit blocking and pre-tuned trap circuitry which can be superimposed within the pod in close proximity, can, without either circuit interfering with the other, efficiently gather, for imaging and tissue analysis, radio frequency signals emanating from magnetically disturbed nuclei in prostate tissue.

Abstract: A method for designing non-linear phase 180° spectral-spatial radio frequency pulses that can be used for spectral editing in magnetic resonance spectroscopic imaging. A novel feature of the pulse is a symmetric sweep developed by the spectral profile from the outside edges of the spectral window towards the middle whereby coupled components are tipped simultaneously and over a short interval. Pulses have been designed for lactate editing at 1.5 T and 3 T. The spectral and spatial spin-echo profiles of the RF pulses can be measured experimentally and altered in an iterative manner. Spectral-spatial radio frequency (SSRF) pulses allow simultaneous selection in both frequency and spatial domains. These pulses are particularly important for clinical and research magnetic resonance spectroscopy (MRS) applications for suppression of large water and lipid resonances.