Abstract: A valve block body includes a monolithic main body formed by additive manufacturing and comprising a plurality of base portions with valve seats accessible via seat openings, a plurality of fastening portions, a plurality of process fluid connections, and a plurality of tubular walls defining internal fluid channels. A biomimetic structure connects the base portions, fastening portions, and tubular walls, and includes features such as variable density, hierarchical branching, and alignment along primary force paths to optimize strength and reduce material usage. The structure can include clamping force transmission portions and tubular support portions. Valve diaphragms can be provided to close the seat openings. The main body can further include a plate-shaped support contour and an outer housing. A fitting assembly includes the valve block body and a drive carrier with valve actuators and movable clamping elements for securing the valve block body during operation.

Abstract: Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.

Abstract: A sensor including a layer having viscoelastic properties, the layer comprising a void, the void filled with a fluid; and optionally, a more rigid sensing element embedded within the layer. When a force is applied to a surface of the sensor, the shape of the void changes, causing the electrical resistance of the fluid in the void to change. When included, the more rigid sensing element can bear upon the void to cause the electrical resistance of the fluid in the void to change. A direction and intensity of the force can be determined by measuring the change of the electrical resistance of different voids positioned about the sensing element. The layer can be an elastomer, preferably silicone rubber. The fluid can be a conductive liquid, preferably Eutectic Gallium Indium. The sensing element can be plastic and can have a “Joystick” shape. The voids can take the form of channels or microchannels having a predefined pattern and/or shape.

Abstract: A drug delivery device for administering a predefined dose of a medicament comprising a housing is presented where the housing includes a body to accommodate a drive mechanism, a cartridge holder to accommodate a cartridge having a piston slidably disposed therein in an axial direction (z), and an interconnection between cartridge holder and body. The interconnection has, at least one displaceable or resiliently deformable latch element to mate with a corresponding bearing, and the latch element is displaceable or deformable in a direction (z, w) extending substantially parallel to a circumferential side wall of the body or cartridge holder.

Abstract: A sensor including a layer having viscoelastic properties, the layer comprising a void, the void filled with a fluid; and optionally, a more rigid sensing element embedded within the layer. When a force is applied to a surface of the sensor, the shape of the void changes, causing the electrical resistance of the fluid in the void to change. When included, the more rigid sensing element can bear upon the void to cause the electrical resistance of the fluid in the void to change. A direction and intensity of the force can be determined by measuring the change of the electrical resistance of different voids positioned about the sensing element. The layer can be an elastomer, preferably silicone rubber. The fluid can be a conductive liquid, preferably Eutectic Gallium Indium. The sensing element can be plastic and can have a “Joystick” shape. The voids can take the form of channels or microchannels having a predefined pattern and/or shape.

Abstract: Exemplary embodiments of disclosure relate to packaging for separately storing, and subsequently mixing, multiple components. The packaging includes a container formed from a first wall and an opposing second wall, wherein a closure splits this container in a leak-proof manner, into a first chamber and a second chamber within said container. The closure is formed from a closure piece arranged on the first wall and a closure counterpiece arranged on the opposing second wall, one part of a spatula forming this closure piece or closure counterpiece. Such a spatula can separate the two chambers from one another as part of the closure system, is always available, and cannot be lost. Furthermore, as a result of its shape, it can be used to mix and administer the contents of the chambers, and to process/apply the mixed multi-component composition.

Abstract: The present invention relates to a drug delivery device for administering a predefined dose of a medicament comprising of housing. The housing comprising of a body to accommodate a drive mechanism, a cartridge holder to accommodate a cartridge having a piston slidably disposed therein in an axial direction (z), and an interconnection between cartridge holder and body, said interconnection having at least one displaceable or resiliently deformable latch element to mate with a corresponding bearing, wherein the latch element is displaceable or deformable in a direction (z, w) extending substantially parallel to a circumferential side wall of the body or cartridge holder.

Abstract: An adapter for attachment to an ironing board includes a housing that can be affixed to a rest plate for an iron. A means is provided on the housing for affixing a socket for the electrical plug of an iron.

Abstract: An adapter for attachment to an ironing board includes a housing that can be affixed to a rest plate for an iron. A means is provided on the housing for affixing a socket for the electrical plug of an iron.