Patents by Inventor Daniel W. Frank

Daniel W. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180333377
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: December 15, 2017
    Publication date: November 22, 2018
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. FRANK, Richard MARTIN, Bassam B. DAMAJ
  • Patent number: 9855231
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 2, 2018
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Patent number: 9517218
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: December 13, 2016
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20160331761
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 17, 2016
    Applicant: Nexmed Holdings, Inc.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20160081954
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: January 7, 2015
    Publication date: March 24, 2016
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20150320764
    Abstract: This invention relates to treating female sexual arousal disorder and/or improving female sexual response, and related symptoms, preferably with topical prostaglandin compositions.
    Type: Application
    Filed: May 8, 2015
    Publication date: November 12, 2015
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Susan Meier-Davis, Daniel W. Frank, Richard Martin
  • Patent number: 8940794
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: January 27, 2015
    Assignee: Nexmed Holdings, Inc.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20140350482
    Abstract: The present invention relates to methods for reconstituting and relates to reconstitution devices suitable for reconstituting many different materials. Furthermore, the present invention includes methods of treatment and methods of use related to a reconstitution device or apparatus. Some embodiments are suitable for reconstituting small amounts of a pharmaceutical compositions and using the pharmaceutical composition for the treatment of sexual dysfunction.
    Type: Application
    Filed: July 6, 2012
    Publication date: November 27, 2014
    Inventors: Bassam B. Damaj, Richard Martin, Michael Mueller, Daniel W. Frank
  • Publication number: 20140200274
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: April 6, 2012
    Publication date: July 17, 2014
    Applicant: Nexmed Holdings, Inc
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20140163464
    Abstract: Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those Components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.
    Type: Application
    Filed: December 3, 2013
    Publication date: June 12, 2014
    Applicant: Nexmed Holdings, Inc.
    Inventors: Yiping Wang, William S. Wei, Daniel W. Frank
  • Patent number: 8596859
    Abstract: Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: December 3, 2013
    Assignee: Nexmed Holdings, Inc.
    Inventors: Yiping Wang, William S. Wei, Daniel W. Frank
  • Publication number: 20100260004
    Abstract: Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.
    Type: Application
    Filed: November 6, 2008
    Publication date: October 14, 2010
    Inventors: Yiping Wang, William S. Wei, Daniel W. Frank
  • Patent number: 7560489
    Abstract: A prostaglandin E composition comprises are substantially free from C1-C4 alcohols and include the prostaglandin E compound together with a (C1-C4)-alkyl(C8-C22)carboxylic ester (e.g., ethyl laurate), an N,N-di(C1-C8)alkylamino substituted, (C4-C18)alkyl(C2-C18)carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: July 14, 2009
    Assignee: NexMed Holdings, Inc.
    Inventors: Daniel W. Frank, Yiping Wang
  • Publication number: 20080090911
    Abstract: A prostaglandin E composition comprises are substantially free from C1-C4 alcohols and include the prostaglandin E compound together with a (C1-C4)-alkyl (C8-C22) carboxylic ester (e.g., ethyl laurate), an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.
    Type: Application
    Filed: October 11, 2006
    Publication date: April 17, 2008
    Inventors: Daniel W. Frank, Yiping Wang
  • Patent number: 6841574
    Abstract: Compounds of prostaglandin E group (PGE compounds) are stabilized as non-aqueous compositions that include the compound together with a bulking agent that can be a non-aqueous liquid or a solid in a sheet, film or powder form. The composition can optionally include a skin penetration enhancer. A non-aqueous, solid dosage form comprises a PGE compound substantially uniformly distributed in a carrier sheet or film.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: January 11, 2005
    Assignee: NexMed Holdings, Inc.
    Inventors: Y. Joseph Mo, Daniel W. Frank
  • Publication number: 20040131664
    Abstract: Compounds of prostaglandin E group (PGE compounds) are stabilized as non-aqueous compositions that include the compound together with a bulking agent that can be a non-aqueous liquid or a solid in a sheet, film or powder form. The composition can optionally include a skin penetration enhancer. A non-aqueous, solid dosage form comprises a PGE compound substantially uniformly distributed in a carrier sheet or film.
    Type: Application
    Filed: January 3, 2003
    Publication date: July 8, 2004
    Inventors: Y. Joseph Mo, Daniel W. Frank