Patents by Inventor Daniel W. McVicar

Daniel W. McVicar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • JANUS FAMILY KINASES AND IDENTIFICATION OF IMMUNE MODULATORS
    Publication number: 20110177526
    Abstract: An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
    Type: Application
    Filed: March 4, 2011
    Publication date: July 21, 2011
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT., OF HEALTH & HUMAN SERVICES
    Inventors: John J. O'Shea, Warren J. Leonard, James A. Johnston, Sarah M. Russell, Daniel W. McVicar, Masaru Kawamura
  • Janus family kinases and identification of immune modulators
    Patent number: 7902348
    Abstract: An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 8, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: John J. O'Shea, Warren J. Leonard, James A. Johnston, Sarah M. Russell, Daniel W. McVicar, Masaru Kawamura
  • Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions
    Patent number: 7553936
    Abstract: The present invention relates to methods and compositions for modulating platelet activity, and methods and compositions for treating a disease or disorder associated with platelet activity in a subject, comprising administering a single chain anti-TREM-like transcript-1 (TLT-1) antibody or a functional fragment or variant thereof in an amount effective to modulate platelet activity.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: June 30, 2009
    Assignee: The United States of America as represented by Secretary Department of Health and Human Services
    Inventors: Toshiyuki Mori, Daniel W. McVicar, Barbara Giomarelli, A. Valance Washington
  • JANUS FAMILY KINASES AND IDENTIFICATION OF IMMUNE MODULATORS
    Publication number: 20090137787
    Abstract: An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 28, 2009
    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEA
    Inventors: John J. O'Shea, Warren J. Leonard, James A. Johnston, Sarah M. Russell, Daniel W. McVicar, Masaru Kawamura
  • Janus family kinases and identification of immune modulators
    Patent number: 7488808
    Abstract: An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: February 10, 2009
    Assignee: United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: John J. O'Shea, Warren J. Leonard, James A. Johnston, Sarah M. Russell, Daniel W. McVicar, Masaru Kawamura
  • Anti-TREM-like transcript-1 (TLT-1) antibodies, methods and compositions
    Publication number: 20080131423
    Abstract: The present invention relates to methods and compositions for modulating platelet activity, and methods and compositions for treating a disease or disorder associated with platelet activity in a subject, comprising administering a single chain anti-TREM-like transcript-1 (TLT-1) antibody or a functional fragment or variant thereof in an amount effective to modulate platelet activity.
    Type: Application
    Filed: December 4, 2006
    Publication date: June 5, 2008
    Applicant: Government of the US, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Toshiyuki Mori, Daniel W. McVicar, Barbara Giomarelli, A. V. Washington
  • Janus family kinases and identification of immune modulators
    Patent number: 7070972
    Abstract: An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: July 4, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: John J. O'Shea, Warren J. Leonard, James A. Johnston, Sarah M. Russell, Daniel W. McVicar, Masaru Kawamura